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F Prelli

Publications and source records attributed to F Prelli.

41 records · Page 3Linked to original sources
PubMed1971

Interchain and intrachain disulfide bridges of a human immunoglobulin M: detection of a unique fragment.

Studies of the amino acid sequences around half-cystine residues in an immunoglobulin M have revealed an unexpectedly high number. At least 14 different sequences were found in the mu chain (V(HIII) subclass). Four of these were involved in interchain disulfide bridges and at least 10 in intrachain bridges. Five came from the kappa chain (kappa(III) subclass, Inv b). Several others, although having a high degree of homology, were not identical with those of either the mu or kappa chains. These results support the concept of an additional fragment in gammaM molecules, although its function and localization remain to be determined.

Amino Acid Sequence↗
PubMedDate not supplied

Amyloid arthropathy: characterization of the amyloid protein.

An 82 year-old man was referred for joint pain and numbness of his hands. Physical examination revealed limitation of movement of the PIP's, MCP's, wrists, shoulders and knees. There was marked synovial thickening of the wrists and atrophy of the thenar muscles of both hands due to arpal tunnel syndrome. The patient was operated on both hands, the median nerves were released and a synovectomy of the wrist was performed. Two months later, a synovectomy of the right shoulder was performed. Histological examination of tissues from the wrists and shoulder demonstrated large deposits of amyloid in the synovia. Amyloid fibrils were extracted, solubilized in 6M and were fractionated on a Sepharose 6B. All three proteins that were purified from the amyloid fibrils proved to be derived from VkI light chain by their amino terminal sequences. This is the first amyloid protein to be characterized from amyloid arthropathy.

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