Helicobacter pylori is known to be responsible for most cases of chronic gastritis, but its role in the outcome of gastric ulcer is unknown. The purpose of this study was to determine the prevalence of H. pylori infection before and after treatment of gastric ulcer, the micro-organism being untreated. The trial involved 26 patients with an acute episode of gastric ulcer, who had undergone endoscopy with biopsy of the antrum, the fundus and the ulcer rim at the initial examination and then 6 weeks and 1 year after the diagnosis. At day 0, 25 acute ulcers were associated with chronic H. pylori gastritis; one patient had neither gastritis nor H. pylori infection. The H. pylori count correlated with the activity of chronic gastritis and with the extension of intestinal metaplasia; it was not modified by the healing of gastric ulcer observed in 24/26 patients on day 360. These results confirm the existence of a close association between H. pylori, chronic gastritis and gastric ulcer. It also suggests that H. pylori is not directly involved in the healing or recurrence of gastric ulcer.

Adult↗

PubMedDate not supplied

[Eosinophilic pancreatitis: a rare manifestation of digestive allergy?].

We report a case of subacute pancreatitis in a 26-year-old woman, who underwent partial pancreatectomy after a two-week history of abdominal pain. The patient had a long history of allergy. She did not show any well recognized cause of acute or chronic pancreatitis. This patient was thought to have eosinophilic pancreatitis because of the presence of a prominent eosinophilic infiltrate in the resected pancreas. Eosinophilic infiltration of the pancreas has been reported very rarely in the literature, and is usually associated with more generalized disease. In our case there was no extrapancreatic involvement, as shown by repeatedly normal blood eosinophil counts, and by histologically normal spleen, celiac lymph nodes, and gastroduodenal biopsies. We suggest that an allergic mechanism might be responsible for this patient's disease, based on past history of allergic manifestations and the important increase in her serum IgE.

Adult↗

PubMedDate not supplied

[Pseudo-alcoholic lesions of the liver in obesity: role of weight loss or associated diabetes?].

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Adult↗

PubMedDate not supplied

[Endoscopic obturation of esophagogastric varices with bucrylate. II. Morphologic study based on 12 autopsy cases].

The authors report the results of postmortem histopathological studies in 12 patients who had been treated by endoscopic obliteration of esophagogastric varices with Bucrylate (isobutyl-2-cyanoacrylate). All patients had cirrhosis; 11 patients were Pugh classe C. Eleven patients had esophageal injections. Acute esophageal lesions were characterized by ulcerations in obliterated varices and diffusion of Bucrylate into the esophageal wall. Chronic lesions were characterized by disappearance of varices and Bucrylate, extending fibrosis of the esophageal wall and re-epithelialization of the mucosa. In one patient who had received gastric injections only, non ulcerated Bucrylate filled gastric varices were seen. Bucrylate seems to have a dual action on esophageal varices: immediate obliteration and acute necrosis of the vascular endothelium. Necrosis causes diffusion of Bucrylate through the esophageal wall, and later, secondary fibrosis whereas the product is progressively eliminated into the esophageal lumen.

Bucrylate↗

PubMedDate not supplied

[Anorectal mucosa prolapse syndrome: a modern and unifying concept of solitary ulcers of the rectum and lesions of the same type].

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Humans↗

PubMedDate not supplied

[Focal lymphoid hyperplasia (pseudolymphoma) of the terminal ileum in adults].

We report two cases of focal lymphoid hyperplasia (FLH) of terminal ileum in adult patients. Both cases showed identical morphological findings. The first was discovered during cholecystectomy in a 75-year-old woman who complained mild non-specific abdominal discomfort. The second was manifested by right lower quadrant abdominal pain in a 32-year-old man. The surgical specimens revealed a thickened wall, a narrowed lumen and multiple ulcerations. The histologic features were small cell, well differentiated lymphocyte infiltration, with several follicles showing large germinal centers; regional lymph nodes revealed a conspicuous reactive size enlargement. Further clinical investigations revealed no other abnormalities. Clinical course showed benign evolution after 6 and 3 years of respective follow-up. FLH should be differentiated from terminal ileum inflammatory and infectious diseases. It can be differentiated from Crohn's disease by the absence of characteristic histological features; from Yersinia infection by the absence of significant rates of specific serum antibodies. Moreover, FLH can be differentiated from malignant lymphoma by the presence of follicles and enlarged germinal centers and by the long-term benign evolution. The nature of FLH in terminal ileum, as well as those of the stomach and colo-rectum is still to be determined. Several hypothesis are proposed: reactive, benign neoplastic, or prelymphomatous lesion?

Adult↗