Biomedical subjects
F Pflücke
Publications and source records attributed to F Pflücke.
[Gastroesophageal reflux--cause of hemorrhaging esophageal varices?].
The results of the examinations do not depend on the peptic theory of the haemorrhage of the oesophageal varices in patients with liver cirrhosis, since the relative frequency of reflux troubles and of gastrooesophageal reflux in patients with liver cirrhosis and haemorrhage of the oesophageal varices was not found greater than in patients with liver cirrhosis and oesophageal varices without haemorrhage as well as the combination of reflux oesophagitis and oesophageal varices was rarely to be observed in the endoscopic material.
[Diagnosis and therapy of primary extranodal non-Hodgkin's lymphoma of the stomach].
In the period from 1970-1980 120 patients with NHL were treated. A primary stomach manifestation could be detected in 6.6%. Problems of pre-operative, endoscopic-bioptic diagnostics are discussed and recommendations for a therapeutic proceeding are given. The tumour is surgically removed at stage I and II, which is always followed by polychemotherapy. Primary polychemotherapy is used at stages III and IV. Patients at stage II achieved a complete remission, those at stage IV died within 6 months after diagnosis.
[Current surgical management of reflux disease].
This disease has not been fully clarified yet. In our opinion, surgery should only be performed in cases of stage IV because of ulcers, irreversible scar formation, metaplasia of the epithelium, endobrachyoesophagus, stenoses or malignant degeneration. 11 patients suffering from severe reflux oesophagitis (stage IV) underwent a combination of supraselective vagotomy (to lower gastric acidity) fundoplication according to Nissen and intraoperative dilatation of the stenosis or stricture. This procedure was effective. Resection of the cardia is a difficult operation full of possible complications and should be reserved only to cases with malignant degeneration (adenocarcinoma).
[Gastroesophageal reflux and gastric secretion].
In 47 patients with reflux complaints and pH-metrically recognizable gastrooesophageal reflux (glass-calomel-electrode system) we succeeded in proving the fact that a large volume of gastric secretion and a lower intragastric pH-value are concomitant with a significant prolongation of the total reflux duration by increase of the reflux frequency.
[Reflux disease and gastric acid secretion].
Between the patients with peptic oesophagitis (n = 28), typical reflux complaints without oesophagitis (n = 60) and pH-metrically establishable gastrooesophageal reflux (n = 58) as well as adequate control groups on an average no differences were the result for the volume of the gastric secretion estimated by aspiration, the concentration of hydrogen ions in the aspirated gastric juice and the computed secretion function of the stomach under basic and stimulation conditions as well as for the pH-value established in the stomach under fasting conditions by means of a glass electrode which can be swallowed.
[Reproducibility of oesophageal sphincter pressure and gastrooesophageal reflux (author's transl)].
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[Lower oesophageal sphincter pressure and gastrooesophageal reflux (author's transl)].
On consecutive days sphincter pressure (pull-through-perfusion manometry) and gastrooesophageal reflux (continuous pH measurements) were determined under basal conditions and after application of pentagastrin (6 microgram/kg b.w.s.c.) in 44 patients. In the half of patients with reflux disturbances of sphincter pressure were not evident under basal conditions and under pentagastrin. In patients with lowered sphincter pressure reflux frequency was found to be higher and single reflux duration was found to be lower than in patients with normal or elevated sphincter pressure.
[Serum gastrin level, oesophageal sphincter pressure, gastro-oesophageal reflux and symptoms of reflux (author's transl)].
Under basal conditions serum gastrin concentration was compared with lower oesophageal sphincter pressure (pull-through perfusion manometry) and gastrooesophageal reflux (continuous pH measurements) in 72 patients. Between patients with low, middle and high basal gastrin level no differences were obtained for mean sphincter pressure. Mean reflux frequency and total reflux duration were increased significantly in patients with high gastrin level compared with patients with low gastrin level. Mean basal gastrin level was found to be higher in patients with symptoms of reflux than in patients without symptoms.
[Comparative studies on the diagnosis of gastroesophageal reflux by roentgen examination and pH-metry].
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[Lymphogranulomatosis and heart involvement].
In the early extralymphatic affection of the organs without relevant clinical and roentgenological findings the diagnosis of the lymphogranulomatosis makes difficulties. It is referred to the peculiarities of the extra-nodal manifestation. The case of a lymphogranulomatosis with early participation of the heart is described and it is gone more fully into the differential diagnosis. Disturbances of the regression of excitation in the ECG are etiologically ambiguous and may be the first recognizable findings of a penetration of a tumour into the pericardium.
[Effect of metoclopramide on complaints of reflux disease].
By sequence analysis was proved that metoclopramide (cerucal, 3 x 10 mg p.o.) in comparison to placebo removes or relieves typical complaints of the reflux disease. Still one week after the end off the treatment with metoclopramide the gastrooesophageal reflux under fasting conditions was significantly decreased compared with the beginning of the treatment, whereas the reflux stimulated under pentagastrin did not show a remaining influence.
[Effect of metoclopramide (Cerucal) on postprandial gastroesophageal reflux].
Postcibal provoked gastrooesophageal reflux of 14 patients with symptoms of reflux was reduced significantly by metoclopramide (Cerucal, 10 mg i. v. or p. o.) for a period of at least 4 hours. Especially metoclopramide was effective in patients with severe symptoms and on 2 patients with endoscopically evident oesophagitis. Metoclopramide was ineffective in 4 patients with slight symptoms whereby therapeutic ineffectiveness may result.
[Reflux disease and sphincter pressure].
Between patients with reflux oesophagitis (n = 8), patients with symptoms of reflux without oesophagitis (n = 27) and controls (n = 17) recordings of lower oesophageal sphincter pressure have shown no significant differences of mean sphincter pressure but a significantly lower increase of mean sphincter pressure in patients with oesophagitis and/or symptoms of reflux after pentagastrin (6 microgram/Kg b.w., s.c.) by means of pull-through perfusionsmanometry. Nearly in half of the patients with oesophagitis and symptoms of reflux basal sphincter pressure and sphincter reaction on pentagastrin were found in a normal range. Disturbances of basal sphincter pressure and its reaction on pentagastrin have shown a dependence on the anamnesis duration.
[Studies about influence of food intake on gastroesophageal reflux. II. Reproducibility of gastroesophageal reflux after a standard meal (author's transl)].
Continuous pH measurements aimed to estimating the gastroesophageal reflux after a standard meal on 3 consecutive days revealed good reproducibility of the number and the duration of reflux episodes per hour (n = 18).
[Studies about the influence of food on gastrooesophageal reflux. III. pH measurements before and after test meals of protein, fat and carbohydrate (author's transl)].
Continuous pH measurements were undertaken on 15 patients for the study of gastrooesophageal reflux during 12 hours after ingestion of test meals of protein, fat and carbohydrate. During 4 hours reflux has been increased by the different diets to similar extents.
[Studies about influence of food on gastroesophageal reflux. I. pH measurements before and after standardized meal (author's transl)].
Continuous pH measurements were undertaken by 87 patients (17 without, 30 with small, 40 with heavy symptons of reflux) for the study of gastroesophageal reflux 1 hour before and after standardized meal. A significant increase of reflux was shown by 19 patients with reflux under dry conditions, whereas reflux was demonstrated by 47 patients for the first time. After meal provocation of reflux was shown by patients with typical symptoms of reflux. An increase of reflux was shown the heavier reflux sumptoms were. pH measurements of gastroesophageal reflux seem to improve the evidence of results after such standardized meal.
[Diagnosis of unusual paraproteins in plasmacytoma--conclusion].
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