[Invasive cervix cancer in spite of gynecologic health control].
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Biomedical subjects
Publications and source records attributed to F Pettersson.
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Five patients, previously treated with pelvic irradiation for cancer of the cervix uteri, ovaries or bladder are presented. They developed occlusions of the distal aorta and/or the iliac arteries 2 to 6 years after irradiation. The presenting symptoms caused by the vascular obstructions were claudication or rest pain. All patients were operated upon with revascularization procedures and thereby relieved from their symptoms. One vascular graft occluded but reoperation was successful. The mechanism by which radiation causes atherosclerosis is discussed. All patients were heavy cigarette smokers. The patients with signs of atherosclerosis outside the irradiated area were the ones with the shortest time interval between radiation and symptoms of ischaemia. It is proposed that irradiation acts synergistically to other atherogenetic factors and this should be kept in mind when radiation therapy is planned in patients with high risk of developing atherosclerosis.
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During the five-year period 1964-68 96 733 births were registered in the 28 hospitals equipped with maternity facilities in the Uppsala hospital region. Of these babies, 1 636 were born in 818 twin deliveries. Data on gestational age, sex, weight and length at birth, birth order, hospital type, congenital malformations and perinatal mortality are analysed. Altogether 17.3 per 1 000 of the children born during this period were born in multiple births. The perinatal mortality for the twin babies was 64 per 1 000 born, with the mortality higher in the less specialized hospitals than the others. Twin no. 1 suffered perinatal death in 67 cases per 1 000 and twin no. 2 in 60 cases per 1 000. For twins of primiparae the losses were 92 per 1 000 children and for twins born to multiparae 51 per 1 000. Altogether 72 per 1 000 male twins died perinatally compared to 52 per 1 000 female twins. The most heavy losses occurred among the low-weight premature twins and in these cases both twins often suffered perinatal death.
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