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Biomedical subjects

F Peeters

Publications and source records attributed to F Peeters.

At least 19 recordsLinked to original sources
PubMed2000

Electrolyte and other blood serum abnormalities in normal weight bulimia nervosa: evidence for sampling bias.

OBJECTIVE: Sampling bias due to research settings might be responsible for reported high prevalence rates of electrolyte and serum abnormalities in bulimia nervosa. The aim of this study was to investigate the prevalence of electrolyte and other serum abnormalities in bulimia nervosa patients with normal weight seeking treatment in a community mental health center. METHOD: Diagnostic evaluations and laboratory tests were done for a consecutive series of 31 patients meeting DSM-III-R criteria for bulimia nervosa. RESULTS: The duration and clinical severity of the eating disorder were considerable and psychiatric comorbidity was high. None of the subjects showed electrolyte abnormalities. Hypomagnesemia was found in 9.7% and hypoalbuminemia in 6.4% of the population. The severity of the abnormalities was modest. DISCUSSION: The results suggest that previous reports on electrolyte abnormalities in bulimia nervosa were affected by sampling bias. Based on the results, there is no indication to perform routinely laboratory studies in ambulatory patients with normal weight.

Adolescent↗
PubMed1998

A rapid method for simultaneous detection of phenotypic resistance to inhibitors of protease and reverse transcriptase in recombinant human immunodeficiency virus type 1 isolates from patients treated with antiretroviral drugs.

Combination therapy with protease (PR) and reverse transcriptase (RT) inhibitors can efficiently suppress human immunodeficiency virus (HIV) replication, but the emergence of drug-resistant variants correlates strongly with therapeutic failure. Here we describe a new method for high-throughput analysis of clinical samples that permits the simultaneous detection of HIV type 1 (HIV-1) phenotypic resistance to both RT and PR inhibitors by means of recombinant virus assay technology. HIV-1 RNA is extracted from plasma samples, and a 2.2-kb fragment containing the entire HIV-1 PR- and RT-coding sequence is amplified by nested reverse transcription-PCR. The pool of PR-RT-coding sequences is then cotransfected into CD4+ T lymphocytes (MT4) with the pGEMT3deltaPRT plasmid from which most of the PR (codons 10 to 99) and RT (codons 1 to 482) sequences are deleted. Homologous recombination leads to the generation of chimeric viruses containing PR- and RT-coding sequences derived from HIV-1 RNA in plasma. The susceptibilities of the chimeric viruses to all currently available RT and/or PR inhibitors is determined by an MT4 cell-3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide-based cell viability assay in an automated system that allows high sample throughput. The profile of resistance to all RT and PR inhibitors is displayed graphically in a single PR-RT-Antivirogram. This assay system facilitates the rapid large-scale phenotypic resistance determinations for all RT and PR inhibitors in one standardized assay.

Acquired Immunodeficiency Syndrome↗
PubMed1996

Interpretation of flow encoding and quantification in MRI: time domain versus frequency domain.

The traditional approach to flow effects in MRI is based on the gradient moment expansion. Recently, we have presented an alternative description by using linear response theory: the distortions of the velocity waveform induced by the gradient waveforms were analyzed in the frequency domain on the basis of the transfer function. In the present paper, we perform an analysis of flow encoding and quantification in the time domain, on the basis of the impulse response. The analysis shows that flow encoding should be interpreted as a weighted averaging process. Instantaneous flow encoding is determined by the centroid of the impulse response, but care should be taken regarding the physical meaning of the instant of encoding. The relationship of this approach to the frequency domain and gradient moment expansion approaches is clarified. By way of example, some interesting applications are investigated: asymmetrical phase encoding gradients to minimize misregistration and oscillating read-out gradients for flow quantification. A variety of new applications are expected to derive from the combination of both the time and frequency domains.

Magnetic Resonance Imaging↗
PubMed1995

Time resolved flow quantification with MRI using phase methods: a linear systems approach.

Phase-related unsteady (pulsatile) flow effects in MRI have been studied by means of linear response theory. These flow effects can be described in the frequency domain: the influence of the gradients on the phase shift is described by a transfer function, the spectrum of the gradient being the determining factor. An analysis of this transfer function is shown to provide information about the process of flow encoding: instant of encoding, induced distortions and how they are related to the gradient waveform. The connection with the traditional description in terms of the gradient moment expansion has also been investigated and clarified. This approach was applied to study the response of two time-resolved flow quantification techniques (Fourier flow method and phase mapping) by analyzing their amplitude and phase transfer functions. By simulation it is shown that a better interpretation of the measured velocity waveform is obtained and that Fourier analysis in combination with a correction by the inverse transfer function results in an accurate reconstruction of the velocity waveform studied.

Algorithms↗
PubMed1986

Myelography using iohexol (Omnipaque).

Myelography was performed in 30 patients using iohexol (Omnipaque) 240 mg I/ml for lateral C1C2 injections, or iohexol 300 mg I/ml for lumbar injections. The dose varied from 3 to 10 ml. The patients were observed for 48 h for possible adverse reactions. A complete neurological examination was repeated 24h after the investigation, and EEG recordings 3-24h after the investigation. Adverse reactions occurred in 4 patients, minor EEG changes occurred in 1 patient, and slight changes in the neurological status were seen in 2 patients.

Adult↗
PubMed1983

Treatment of vaginal candidosis with oral ketoconazole.

Results with ketoconazole were studied in 281 non-pregnant patients with acute and chronic Candida-vaginitis. Several dose regimens were evaluated. The 5-day regimens (200 mg b.i.d. or 400 mg once daily) seem to be the most appropriate schedules in this infection. Side effects were minor. Relapse rates are not different from those, historically known, with topical antifungals.

Administration, Oral↗
PubMed1983

Iopamidol for myelography. A clinical trial with a new non-ionic contrast medium.

289 myelographies with the non-ionic, water-soluble, contrast medium iopamidol were performed. These were subdivided into 153 lumbar, 49 ascending thoracocervical and 87 cervical myelographies. For the latter a lateral C1-C2 puncture was used. The iodine concentration given was 200 mg/ml for the lumbar examinations and 300 mg/ml for the cervical and thoraco-cervical examinations. The total iodine never exceeded 3 g. Image quality is not different to metrizamide of equal iodine concentration. Adverse reactions did not exceed those known for metrizamide. Mild and transient side effects occured in 45%.

Clinical Trials as Topic↗
PubMed1980

A shortened regime for the treatment of vulvovaginal candidosis with a new presentation of miconazole.

A new presentation of miconazole, in the form of soft gelatin capsules for intravaginal use, gave considerable therapeutic success in the treatment of vulvovaginal candidosis. Mycological cure rates greater than 85% and clinical cure rates greater than 90% were achieved by treatment with 7 miconazole capsules, regardless of whether these were used daily for 7 days or twice daily for 3 1/2 days. The new formulation seems to possess the dual advantage of ease of application and shorter duration of treatment.

Adolescent↗
PubMed1979

[The lateral projection with an inclined beam for the demonstration of aneurysms of the anterior communicating artery and of the middle cerebral artery (author's transl)].

In addition to the a.p. and lateral projections for the diagnosis of aneurysms of the anterior communicating artery, the literature also recommends oblique views by turning the head to right or left with an a.p. beam. Lateral views, turning the head 20 degrees to the side of injection often provide better demonstration of the origin of the aneurysm and its relationship to surrounding vessels.

Adult↗
PubMed1977

The value of computer tomography, orbital venography and carotid angiography in the diagnosis of exophthalmos.

On the bases of 25 patients examined by orbital venography, computer tomography, (CT scanning) and sometimes carotid angiography, the diagnostic value of each of these methods is evaluated. The data obtained are compared with the corresponding information from the literature. In view of the findings it can be stated that CT scanning can be regarded as the primary neuroradiological examination in cases of exophthalmos. Orbital venography gives supplementary information in cases of varices and venous malformations. Angiography is the method which supplies the maximum of information when cavernous sinus fistulae are clinically suspected. With reference to 3 patients it is explained that in such selective angiography of the internal and external carotid and the vertebral artery is indicated.

Adolescent↗