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Biomedical subjects

F Patel

Publications and source records attributed to F Patel.

At least 37 records · Page 2Linked to original sources
PubMed1997

Results of treatment in endometrial carcinoma: ten years experience.

From 1980 to 1989, 145 patients of histologically proven adenocarcinoma of the endometrium were seen and treated at the Department of Radiotherapy, Postgraduate Institute of Medical Education and Research, Chandigarh, Majority of the patients (84/145) presented with FIGO stage I disease. Relationship of myometrial invasion to grade was highly significant (p < 0.001). One hundred and seven patients were treated by surgery in combination with pre-operative or post-operative radiotherapy. The importance of various prognostic factors was assessed and grade of the tumour had statistically highly significant effect on survival (p < 0.005). Postoperative radiotherapy is recommended in patients with poor prognostic factors.

Combined Modality Therapy↗
PubMed1996

A high fatal postmortem blood concentration of cocaine in a drug courier.

A fatality in a teenage drug courier who swallowed multiple packages of a controlled drug for concealment in the gastrointestinal tract is described. There were a couple of burst-open short cylindrical packages of cocaine and several with damaged external latex wrapping. A hazardous breakage or leakage has been considered unlikely with similar type of cocaine packages otherwise. The deceased succumbed to a remarkably high fatal postmortem blood cocaine concentration of 104 mg/l, having curiously survived the usual lethal range for cocaine toxicity. The phenomenon of postmortem release and redistribution of drugs and spontaneous biodegradation of cocaine which may confound the postmortem toxicology is briefly discussed. There is a comparable forensic problem in estimating the time of drug ingestion from the rate of gastric emptying or transit in the gut as a crude guide to deduce the time of death.

Adolescent↗
PubMed1996

Traumatic baso-brainstem subarachnoid haemorrhage.

Traumatic basal subarachnoid haemorrhage is an uncommon disorder that is well described in the forensic literature. The aetiology traditionally has been a relatively minor blunt trauma which is sustained typically at the level of the base of head and injures the arterial system to the brain. The site of trauma may be occult and not always demonstrable. In the case discussed, an acute baso-brainstem subarachnoid haemorrhage was caused by a severed extracranial vertebral artery due to a stabwound injury to the upper neck. A gravitational factor and alcohol intoxication, which might contribute to the basal intracranial haematoma, is given a novel thought.

Adult↗
PubMed1995

Ancillary autopsy--forensic histopathology and toxicology.

Under the Coroners Act 1988 and the Coroners Rules 1984, the removal of parts or contents of the body which does not bear directly upon the cause of death is restricted. However, it may not be possible in every forensic necropsy to foretell whether the post-mortem removal of body tissue will fulfil a statutory proviso. To emphasize this medico-legal predicament, some examples in which ancillary histopathological examination or toxicological analysis assisted in ascertaining an accurate cause and manner of death are presented as short cases.

Adult↗
PubMed1995

Artefact in forensic medicine: pseudo-rodent activity.

Postmortem rodent activity is a potential source of confounding marks for forensic pathologists when unmasking criminal activity. It might also be that something innocent could be masquerading an "end result" of rodent disturbance. A chronic skin lesion which proved to be a "pseudo-rodent" artefact is briefly communicated and supplements an earlier published article on artefact in forensic medicine.

Aged↗
PubMed1994

Comparison of chorionic villus sampling and amniocentesis for fetal karyotyping at 10-13 weeks' gestation.

We did a prospective study of women with singleton viable pregnancies at 10-13 weeks' gestation who requested first-trimester fetal karyotyping because of advanced maternal age, parental anxiety, or family history of chromosomal abnormality. Women were counselled as to the available options of non-invasive screening or invasive testing by mid-trimester amniocentesis, early amniocentesis (EA), or chorionic villus sampling (CVS), or randomisation to EA or CVS at 10-13 weeks. EA was done in 731 patients (493 by choice and 238 by randomisation) and CVS in 570 (320 by choice and 250 by randomisation). Both procedures were done by transabdominal ultrasound-guided insertion of a 20-gauge needle. The rate of successful sampling was the same for both procedures (97.5%). Spontaneous loss (intrauterine or neonatal death) was significantly higher after EA (total group mean = 5.3%, 95% CI 3.8-7.2; randomised subgroup mean = 5.9%, 3.3-9.7) than after CVS (total group: mean = 2.3%, 1.2-3.9; randomised subgroup: mean = 1.2%, 0.3-3.5). The gestation at delivery and birthweight of the infants after EA and CVS were similar. In the EA group the incidence of talipes equinovarus (1.63%), was higher than in the CVS group (0.56%), but this difference was not significant.

Adult↗
PubMed1994

Artefact in forensic medicine: non-missile penetrating injury.

Gunshot wounds are well characterised in forensic textbooks and atypical or unusual ballistic characteristics feature regularly in forensic literature. Forensic practitioners receive continuing education in recognising a variety of gunshot wounds which are created by bullet missiles. Awareness of a non-missile penetrating injury mimicking a gunshot wound is also relevant to forensic medical examiners or others who are likely to attend a scene of death. In this case, which involved self-stabbing with a metal nail, a homicidal firearm death investigation was instigated because of a misinterpretation by crime scene investigators.

Journal Article↗
PubMed1994

Diabetic death bed: post-mortem determination of hypoglycaemia.

The post-mortem biochemical determination of hypoglycaemia in the practice of forensic medicine is notoriously imprecise and attracts perennial criticisms, particularly from those who may be alien to the peculiarities of medical jurisprudence. There has been re-emphasis recently on the neuropathological pathoclisis ascribed to prolonged hypoglycaemia. Unfortunately, the value perceived is limited by pathognomonic unreliability owing to agonal multifactorial influences and rapidly fatal nocturnal hypoglycaemia. The predicament is oppressive to a consideration of preponderant evidence and an unpopular diagnosis of peri-mortem hypoglycaemia, unless audacious, may be precluded simply because the proof is difficult. This is likely to contribute to diagnostic under-estimation of enigmatic diabetic deaths. A suspected case of lethal nocturnal hypoglycaemia in a young diabetic on 'animal' insulin is presented to restore some perspective to the clinico-pathological deference for an endangered post-mortem diagnosis of hypoglycaemia inferred from minimal evidence.

Adult↗
PubMed1994

Artefact in forensic medicine: postmortem rodent activity.

The human body may be attacked by a variety of animals. It is a potential source of confounding marks for forensic practitioners when unmasking criminal activity. A case that posed some problems for the crime scene investigators on discovering a dead body indoors, which had both ears missing is discussed. The suspicion initially was that of homicidal mutilation of the corpse. A general awareness of artefactual postmortem animal activity may avoid their misinterpretation. This short report acknowledges a persistent paucity in the forensic literature on the subject of human remains and postmortem animal activity.

Aged↗
PubMed1993

Artefact in forensic medicine. Fetal congenital abnormality.

A case of congenital defect in an abortus is described and the forensic implications of unawareness of childhood artefactual abnormalities which may appear to have a cryptogenic criminal etiology are reiterated. This is apparently the first case reported in which gastroschisis had been misconceived to be criminal abortion.

Abdominal Muscles↗