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Biomedical subjects

F Paquelin

Publications and source records attributed to F Paquelin.

At least 19 recordsLinked to original sources
PubMed1991

[Cancer arising in a cyst of the thyroglossal tract].

Two new cases of thyroglossal cyst carcinoma are reported. Such cancers concern rather young women. The diagnosis must be suspected whenever a thyroglossal cyst is associated with cervical adenopathies. The most performing investigation seems to be fine-needle aspiration guided by echography. The malignant diagnosis is made during surgery by frozen section of the lesion, confirmed by histology. Two type of cancer must be distinguished: squamous cell carcinoma and carcinoma of thyroid type. The management of squamous cell carcinoma includes a large resection. For thyroid type carcinomas, total thyroidectomy and bilateral neck dissection are to be considered. Because of up-to-date insufficiency following, it is difficult to make a prognosis.

Adolescent↗
PubMed1989

[Cholesterol granuloma of the middle ear. Apropos of 3 cases].

Cholesterol granulomas arise scarcely within the middle ear cavities revealed by a conductive deafness. They appear on the CT scan as a non specific mass developed in the middle ear cavities with bone defects. MRI allow the diagnosis as cholesterol granulomas is defined by hyperintensity on all sequences.

Adult↗
PubMed1987

[Effects of mannitol on the fluids of the internal ear. Use in the treatment of deafness].

The action of mannitol upon the inner ear fluids was studied experimentally by means of kinetics of mannitol entry into cochlear perilymph and endolymph in rats. A daily two hours infusion of 10% mannitol induces an osmotic water flow from cochlear fluids toward plasma. Following this therapeutic protocol, progressive, non-tumoral sensorineural hearing loss is enhanced in 32% of the cases. The rate of hearing improvement is larger than 50% in case of Ménière's disease. For sudden hearing loss, 75% of the cases are improved by mannitol, and 92% of the cases when the delay between the hearing loss onset and the mannitol therapy is less than two weeks. Sudden hearing loss should be considered as a sensory emergency.

Adult↗
PubMed1984

[Recent data on malignant melanoma of the upper respiratory and digestive tract mucosa. Apropos of a case].

The choice of a therapeutic strategy for the treatment of mucosal malignant melanomas from upper digestive and respiratory tracts remains difficult. This is due to the very low frequency of such malignancies and to the subsequent scarcity of data on parameters of diagnosis and prognosis. Such informations have been available on cutaneous malignant melanoma as they have been known for a longtime and occur with much higher frequency. Parameters of diagnosis and prognosis have been determined from randomised clinical traits. Based on such parameters a more efficient therapeutic strategy can be applied to the various clinical cases. In this paper we review these parameters and in particular those which seem to apply to the mucosal malignant melanomas from upper digestive and respiratory tracts. Finally we report on currently used therapeutic protocols and we present recent data from the literature on adoptive immunotherapy of malignant melanomas in mice.

Adolescent↗
PubMed1983

[Periodic laryngeal dyspnea in bi-opercular syndrome].

Periodic bouts of laryngeal dyspnea in a 77-year-old man were observed early in the course of a syndrome due to bilateral opercular infarcts. Laryngoscopy showed alternate slow opening and closure of the glottis superimposed on respiratory vocal cord movements. The disorder could result from bilateral removal of cortical control of bulbar centers, its periodicity suggesting analogies with Cheyne-Stokes' dyspnea.

Aged↗
PubMed1983

[Acquired facial paralysis in children. Our experience apropos of 72 cases].

Results of therapy as a function of etiology are discussed in relation to 72 cases of acquired facial palsy in children. Spontaneous recovery occurred in 28 of the 33 cases with idiopathic facial palsy, this representing the most common form (46 p. cent of total) and appearing to have a still better prognosis than in adults. An infectious origin was determined in 19 cases (26 p. cent). Medical treatment produced complete recovery in 7 of the 8 cases with otitis, while simple mastoidectomy relieved 8 of the 11 patients with facial palsy due to mastoiditis. The indications for operative intervention should be widened in post-traumatic cases (14 in this series) with immediate onset of paralysis. Similarly, medical treatment of secondary paralysis should not delay surgery in cases with no regression after three weeks.

Adolescent↗
PubMed1983

[Neonatal facial paralysis. Our experience apropos of 44 cases].

Forty-four cases of neonatal facial paralysis have been treated in the ENT department for children in the hôpital Trousseau, paris. In nearly half of the cases the etiology was related to nervous or muscular aplasia, while in the other cases of traumatic, infective, or doubtful etiology, the severity and course of the paralysis served as a guide to choice of therapy. Surgery was indicated in only 13 cases and recovery was obtained in 4 infants, with more or less marked sequelae. Prognosis is very poor in cases treated at a late stage, especially when the nerve appears to be greatly altered or compressed by callus. Surgical exploration should therefore be undertaken reasonably early (6 weeks to 2 months) when total paralysis persists or becomes worse after initial improvement.

Birth Injuries↗
PubMed1982

[Therapeutic approach to laryngeal nerve paralysis].

The numerous surgical procedures proposed for the treatment of bilateral recurrent laryngeal nerve paralysis, since the operation first described by Rethi, are reviewed. Because of the principle involved and the simplicity of Loboryles operation it is the preferred method, and the technique employed is described in detail. Results have been satisfactory in a series of patients treated by this procedure and its further development is justified.

Humans↗
PubMed1980

[Trans-tympanic aeration in mastoiditis. Study of 42 cases (author's transl)].

The authors review the diagnostic protocol of mastoiditis based upon 382 cases with 1.3% errors (histological confirmation). Up to the present time, mastoidectomy was the only treatment which could be envisaged. In a new series of 90 cases, 48 constituted the control group and 42 the study group, trans-tympanic drains were inserted routinely in the latter. It was thus possible to avoid mastoidectomy in 62% of cases in the study group (evaluation based upon the number of ears). The period of postoperative observation was on average 8 months. No complications related to the drain were seen. Up to the present time, there exist no precise criteria which may be used to decide between insertion of a drain or mastoidectomy from the outset. Insertion of a drain must thus be considered as a therapeutic test, justified by its harmlessness and simplicity.

Child↗
PubMed1979

[Pathological manifestations of tonsillar hypertrophy (author's transl)].

The authors describe the rare but essential indication for tonsillectomy in the child based upon 4 personal cases of pseudolaryngeal dyspnoea during sleep due to prolapse of the tonsils in the hypopharynx. They indicate the grave cerebral and cardiac consequences which could result from neglect of this symptom which at first sight has the characteristics of ordinary snoring. Paediatricians, anaesthetists and laryngologists are equally concerned by this alveolar hypoventilation of high obstructive origin.

Child↗
PubMed1978

[Assessment of a thirty year long experience in treatment of esophageal caustic stenosis (author's transl)].

Among 457 esophageal stenosis treated between 1954 and 1977, 258 (56%) were caustic stenosis. The treatment of those is the most difficult. Functionnal healding was satisfactory in 93% of the treated cases by dilatations. Four strict rules ought to be observed in the management of this cases. Immediate and long terme antibiotic treatment of the corrosive esophagitis. X rays are the only means to be used during evolution of corrosive esophagitis. No instrumental performance until sufficient cicatrization. Retrograde dilatations after gastrostomy shall be prefered in serious cases. Gastro-esophageal reflux may complicate this evolution and require surgery. Total esophageal replacement can be averted in most cases.

Anti-Bacterial Agents↗