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Biomedical subjects

F Ottaviani

Publications and source records attributed to F Ottaviani.

134 records · Page 8Linked to original sources
PubMedDate not supplied

PCNA--a cell proliferation marker in vocal chord cancer. Part I: Premalignant laryngeal lesions.

Laryngeal hyperkeratotic lesions can progress to fully developed malignant carcinoma in some cases. These premalignant lesions are proliferative disorders whose potential for further tumour progression is perhaps difficult to assess by mere histology. Immunostaining with PCNA, a protein correlated with cell proliferation, has been used to study tissue behavior in 30 cases of premalignant laryngeal vocal chord lesions treated by epithelial stripping in microlaryngoscopy, 15 of whom had no progression and 15 had recurrence and final development of full malignancy. The results showed a statistically significantly higher PCNA-index in the cases which underwent further tumour progression towards malignancy. PCNA testing may thus be suggested as a marker for tumour progression potential and help in determining clinical treatment choices.

Humans↗
PubMedDate not supplied

Carcinoma of the vocal cord. Results after subperichondral cordectomy.

The clinical outcome of 110 patients operated upon by subperichondral cordectomy between 1982 and 1992 for T1s/T1a, NO, MO carcinomas of the vocal cord has been evaluated in this longitudinal epidemiological study. Patients have been followed up until the end of 1993 by examinations done once a month (first year), every three months (years 2 to 4), every six months (years 5 to 8), and then once a year. Life-tables have been computed according to Kaplan and Meier and raw survival has been 90.0%. Considering only the mortality due to any type of neoplastic disease, the survival reached 93.6%. Finally, considering only deaths due to recurrences or metastases of the primary tumor, the survival rate was 95.5%. Mortality after the first recurrence was 27.3%, after a second recurrence 50.0%. A correlation between number of cigarettes smoked and the risk of recurrence of the tumor could be observed (p < 0.01), while gross appearance and histologic grading of the vocal cord carcinoma proved to be uncorrelated with the risk of recurrences.

Adult↗
PubMedDate not supplied

[Use of microsystems for the identification of Enterbacteria in the microbiological laboratory: comments on technics and identification procedures].

The Authors have pointed out the characteristics of 3 miniaturized systems for the enterobacteria identification: Enterotube, API 20 E, Minitek. They particularly described the accuracy in biochemical reactions and the agreement between the mini-systems identifications and conventional (routine media) identifications (and reactions); all the identification errors made with micro-systems are reported and explaned. Nine atypical strains, which give some identification problems, are reported with all the biochemical profils. The more typical characteristics of the 3 miniaturized systems are summarized in a table.

Bacteriological Techniques↗
PubMedDate not supplied

[Isolating and enriching broths of Salmonellae].

The Authors have tested in 3 isolating and enriching broths some Salmonellae; the broths are available commercially (MUELLER-KAUFMANN broth, LEIFSON broth and HAJNA GN broth) and they tested their inhibitory capacity (concerning the growth of intestinal saprophyte flora) and their enriching capacities with regard to the various types of Salmonellae also. The method used consists in an exact evaluation of the increase percentage of the germs which were put to incubate in the broths at 37 degree C for 6, 15 and 24 hours. On completing the tests it is clearly evident that the MUELLER-KAUFMANN and the LEIFSON broths are far superior to the HAJNA broth (which proved to be not very activated in decreasing the growth of the intestinal saprophytes). At the same time, it should be pointed out the opportuneness of effecting the re-transplantation from the Salmonellae broths only after 24 hours, in order to permit a more abundant growth of the Salmonellae (and therefore easier and surer isolation) without, at the same time, observing an appreciable interference by the common intestinal saprophytes.

Bacteriological Techniques↗
PubMedDate not supplied

Esthesioneuroblastoma: a general review of the cases published since the discovery of the tumour in 1924.

Esthesioneuroblastoma (ENB) arises from the neuroepithelium in the olfactory rim of the nasal cavity. It accounts for about 3% of all intranasal tumours. Reviews since the first description by Berger and Luc in 1924 never reported more than a hundred cases, stressing the rarity of the tumour. However, a thorough literature review revealed a total of 945 reported cases. In our search we found a total of 1,457 cases chronicled in the literature of which perhaps 487 were cited in more than one paper, bringing the total of reported cases to 945. Author cases accounted for 198 and therefore collaborative efforts accounted for 747 cases. Sex distribution was 53.36% male and 46.64% female. Kadish classification was applied to 553 cases revealing 103 (18.29%) class A cases, 182 (32.33%) class B and 278 (49.38%) class C cases. This distribution was generally stable through the decades. Treatment could be classified in 898 cases. It consisted of surgery alone in 25.17% (226 cases), radiotherapy alone in 18.37% (165 cases), combined surgery and radiotherapy in 43.21% (388 cases) and chemotherapy in 13.2% (119 cases), followed in 11 cases (1.22%) by bone marrow transplant. In the reported cases an overall follow up could be evaluated in 477 cases, while in only 234 cases a five-year follow up was done. The outcome was 68.38% alive and disease free, 12.82% alive with disease and 18.80% dead. From these 20.51% had surgery only, 11.11% radiotherapy and 68.38% combined surgery and radiotherapy. The best survival rates were obtained by combined therapy (72.5% vs. 62.5% surgery alone and 53.85% radiotherapy alone). Death rates were highest after radiotherapy alone (30.77% versus 18.75% in combined therapy and 12.50% after surgery alone). In conclusion, ENB is a rare but not exceptional tumour. It is best treated with combined surgery and radiotherapy. Unfortunately early diagnosis is still uncommon and no significant changes to the proportions of Kadish classes at first diagnosis have been noted in recent decades. A greater awareness of the tumour and earlier diagnosis seems the major focus for future research.

Adolescent↗