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Biomedical subjects

F Olesen

Publications and source records attributed to F Olesen.

At least 127 records · Page 7Linked to original sources
PubMed1988

A case-control study of cervical cytology before diagnosis of cervical cancer in Denmark.

The number of previous vaginal smear examinations in 428 patients who developed invasive cancer of the cervix was compared with previous screening in age- and area-matched controls. The average age was 53 years. There was a highly significant difference in the numbers who had never undergone screening, ie 55% of the cancer patients and 33% of the controls. Equally there was a highly significant difference between cases and controls in the number examined according to recommended guidelines for prophylactic examination. It was shown that about 40% of the cytological tests were done for gynaecological reasons, and it is probable that the number of false negatives among the cases was not negligible. Despite this, however, regular screening reduced the relative risk of cancer to about 0.25, compared with those never examined. When only symptomless patients were considered in the assessment of regular screening, the relative risk was reduced to 0.15 in patients screened every three years. Even the group which was screened more than five years previously had a relative reduction in risk to 0.67, compared with those never screened. It is concluded that PAP-smears are important in the prevention of cancer of the cervix. The greatest need is to eliminate the group which is never examined. An increase in the number of screenings has only a marginal benefit.

Adenocarcinoma↗
PubMed1988

Factors affecting prescription of psychotropic drugs in general practice.

During one week in 1985, 227 general practitioners (GPs) in the county of Aarhus, Denmark, recorded all their prescriptions of psychotropic drugs, amounting to 4,180 prescriptions for 3756 patients. There was great variation in the rate of prescribing among the GPs. The median number of prescribed defined daily doses per 1,000 registered patients per day was 84, and the corresponding median number of prescriptions per 1,000 patients per week was 14. There was a significantly lower rate of prescribing of psychotropic drugs by rural/small town GPs, compared with GPs in major cities (odds ratio, 0.84; 99% confidence limits, 0.77-0.91), after correction for differences in patients' age and sex. There were no differences in rate of prescribing among GPs in relation to size and type of practice, nor to the age and sex of the GP.

Age Factors↗
PubMed1988

The pattern of attendance at general practice in the years before the diagnosis of cervical cancer. A case control study.

The study concerned a nation-wide Danish investigation of 519 women who received the diagnosis of cancer of the cervix uteri in 1983. Data on doctor-contact patterns during the single year, and for the 3 years pre-diagnosis were obtained on 428 of the women (82%), and a comparison was made with an age- and practice-matched control group. Significantly more patients than controls had had no doctor contact, and their odds rate for cancer development was higher than that of the patients who had had at least one contact with their general practitioner during the previous one or three years. Those patients with more advanced stages of cancer, those who had never had a cytological examination, and those living in counties without organized screening programmes were in general the ones with fewest doctor-contacts, and the odds rates for cancer development among the no-contact patients were highest in these groups. No doctor-contact was more common among patients living in counties without organized screening programmes, and these women represented a relatively higher risk group than those living in counties with organized screening. More women are thus caught in the organized screening net, compared with unsystematized screening. The findings support systematic rather than opportunistic unsystematic screening for cancer of the cervix.

Adult↗
PubMed1988

Prophylactic cytological investigation for cervical cancer in relation to stage at diagnosis: a study of 420 women in Denmark.

Despite widespread cervical smear testing 500-600 cases of cancer of the cervix are still diagnosed each year in Denmark, with over 200 deaths. The distribution of the different stages of cancer among 420 women who were diagnosed during 1983 was correlated with the number of previous cervical smears, whether done purely for screening reasons or for minor gynaecological problems. Of the women with cancer 56% had never been screened, and among these 42% were diagnosed at stage 1; 19% had been screened once; 61% of them at stage 1. The remainder (25%) had been screened at least twice, and 81% of them were diagnosed at stage 1. Among the patients who had been screened at least twice, with the last screening not more than three or five years ago, about 90% were diagnosed at stage 1 and the rest at stage 2.The introduction of cervical smear testing will thus mean a considerably better stage distribution among cases which develop invasive cancer of the cervix, and both case fatality and mortality rates will be reduced by organized programmes, which have better participation rates than disorganized use of cervical smears.

Denmark↗
PubMed1986

Use of Pap smear in general practice by case finding or screening programme.

Two different organizational methods of Pap smear examination in prevention of cancer colli uteri are compared in two Danish counties. In one county the method was planned as a pure case finding model; in the other county a modified screening approach was used. Resources were measured as the number of Pap smear examinations per 1 000 women of risk age (25-54 years). They were nearly identical in the two counties. The number of sufficiently investigated women, defined as examined by a Pap smear at least once within a 3-year period, was much larger in the county using the screening model than in the other county. Furthermore the proportion of women sufficiently investigated varied greatly in the county using the case finding model. Even the most active one-fourth of the doctors in this county did not obtain the same percentage of examined women as the average in percentage of examined women in the county with a regular screening programme, even though this active group of doctors had a resource consumption about twice the average for this county. It is concluded that the Pap smear method when aiming at a maximum interval between smears in individual women of 3 years, can be conveniently carried out in general practice by using a case finding model in combination with a screening programme together with a systematized, centrally computer-surveyed procedure, in order to avoid overlapping and exclude women not examined as well as possible.

Adult↗