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Biomedical subjects

F Ojo

Publications and source records attributed to F Ojo.

3 recordsLinked to original sources

Frequency of low bone mass in elderly males attending an academic geriatric clinic: a pilot study.

The objective of this prospective study was to evaluate the frequency of low bone density in elderly males seen in an academic geriatric practice and to evaluate physician awareness of male osteoporosis among academic geriatricians. The participants were elderly community-dwelling ambulatory males aged 65 years and older (n = 35). The mean age was 80.7 +/- 8.2 years, with eight subjects in the 65-74 years range, 16 in the 75-84 years range and 11 over 85 years. Only 5/35 utilized an assistive device for ambulation. Bone mineral density (BMD) was measured using a heel ultrasound (QUS-2 calcaneal ultrasonometer). Clinical risk factors, gait and balance were evaluated (Tinetti scale). Results of BMD were communicated to the attending geriatrician. In all 7/35 participants had a calcaneal T-score of < or = -2.5 indicating osteoporosis, of these 50% were > 85 years; 7/35 had t score of -1 to -2.5 indicating osteopenia, of these 50% were 75-84 years; and 21/35 had a T-score > -1 indicating normal BMD). Overall, 14 of the 35 subjects studied had low bone density. Gait disorders were seen in 18/35 subjects (p < 0.05), more commonly in the oldest subjects. Risk factors for osteoporosis-related fractures included smoking (n = 22, 63%, p = 0.57), gait abnormalities (n = 18, 51%, p < 0.05) and alcohol use (n = 13, 37%, p = 0.39). Low bone mass (osteopenia or osteoporosis) was not addressed (by record notations, request for DEXA, laboratory testing or medical treatment) within 6 months by the majority of geriatricians (3/5). This pilot study shows a high frequency of low bone density in elderly males seen in an academic geriatric practice. This frail population presents with significant balance and gait disorders, and the coexistence of these two risk factors predisposes them to the development of hip fracture. This study also underscores the importance of increasing awareness of osteoporosis in males among geriatricians. Limitations to this study are that bone density was measured with the QUS-2 calcaneal ultrasonometer, and that female reference values were utilized. These limitations potentially under-estimate the prevalence of bone loss in males.

Absorptiometry, Photon↗

Vancomycin-resistant gram-positive cocci: risk factors for faecal carriage.

This case-control study was undertaken to identify the risk factors for the gastrointestinal carriage of vancomycin-resistant, Gram-positive cocci (VRGPC) including vancomycin-resistant enterococci (VRE). Use of oral vancomycin (P = 0.003) or cephalosporins (P = 0.03) and prolonged duration of stay in the hospital (P = 0.02) were found to be the significant risk factors. Other previously suggested risk factors such as location of the patients and presence of central venous or arterial lines were not significantly associated with carriage of VRGPC. Judicious usage of glycopeptides (particularly oral vancomycin) and cephalosporins is likely to be the most effective way to prevent and control the spread of VRGPC and VRE.

Aged↗

Selective medium for screening for vancomycin-resistant enterococci in faeces.

Infections caused by vancomycin-resistant enterococci (VRE) are becoming increasingly prevalent throughout the world. Control measures include detection and isolation of carriers of VRE. A selective medium to detect faecal carriage of VRE is described. The medium has a high productivity ratio (90.4%) for VRE with VanA resistance phenotype, a moderate productivity ratio (79.2%) for VRE with VanB resistance phenotype, and a relatively low productivity ratio (65.5%) for VRE with VanC resistance phenotype. There was no breakthrough of vancomycin-susceptible enterococci. The medium selected the growth of all three types of VRE, which were used to spike faecal specimens. In a limited clinical trial, six faecal specimens of carriers and contacts were screened using the selective medium. Vancomycin-resistant enterococci (Enterococcus faecalis, VanA phenotype) were detected in four of the specimens. In all four specimens the growth of VRE was nearly pure and easily identifiable.

Anti-Bacterial Agents↗