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Biomedical subjects

F O Stephens

Publications and source records attributed to F O Stephens.

104 records · Page 6Linked to original sources

The rising incidence of breast cancer in women and prostate cancer in men. Dietary influences: a possible preventive role for nature's sex hormone modifiers - the phytoestrogens (review).

The rise in breast cancer in women and prostate cancer in men in Western societies this century, stimulated a search for any possibly reversible aetiological associations common to both. Apart from more citizens living to an older age the most significant associated factor in common is the dietary practices of communities most at risk, particularly a decreasing Western dependence on plant foods with increasing dietary animal fats. Plant foods, especially legumes like soy, contain phytoestrogens (plant oestrogens). They are natural hormone modifying agents and give balance to levels of circulating hormones in both sexes. Animal fats hinder hormone modulation. They retain and slowly release unwanted stored hormones. To reverse this situation Western communities could revert to Asian type diets with high soy content but a more practical approach might be to add concentrated soy or other phytoestrogen product to a fat reduced Western diet.

Breast Neoplasms↗

Developments in surgical oncology--past, present, and future trends.

The historical development of integrated treatment programs for locally advanced or aggressive cancers, for which the results of surgical excision or radiotherapy are unsatisfactory, is reviewed. Chemotherapy should be used first (induction chemotherapy), while tumour vasculature is intact; intra-arterial infusion gives a greater regional effect. Central residual tumour may be eradicated by subsequent radiotherapy and/or surgery. Regional induction chemotherapy is particularly useful in treating locally advanced stage III breast cancer, locally advanced head and neck cancer, gastric cancer, and locally advanced sarcomas and melanomas of the limbs. A team approach, involving surgical and medical oncologists, radiotherapists, immunologists, and others should improve the results in these patients.

Combined Modality Therapy↗