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Biomedical subjects

F Nault

Publications and source records attributed to F Nault.

17 recordsLinked to original sources
PubMed2000

Characteristics of the interaction between Hsc70 and the transferrin receptor in exosomes released during reticulocyte maturation.

The transferrin receptor (TfR) of reticulocytes is released in vesicular form (exosomes) during their maturation to erythrocytes. The heat shock cognate 70-kDa protein (Hsc70) has been demonstrated to interact with the cytosolic domain of the TfR and could thus trigger the receptor toward this secretion pathway. We investigated the characteristics of the interaction between Hsc70 and the TfR in exosomes with an in vitro binding assay using TfR immobilized on Sepharose beads and purified Hsc70. The results show that Hsc70 binds to exosomal TfR with characteristics expected of a chaperone/peptide interaction. We demonstrated that heat-denatured luciferase competed for in vitro binding, dependent on the nucleotide bound to Hsc70, and that this interaction activates the ATPase activity of Hsc70. Moreover, we used immunosuppressive agents that interact with Hsc70, thus decreasing Hsc70 binding to TfR in our in vitro binding assay and enabling us to assess the role of this interaction in vivo during reticulocyte maturation.

Adenosine Triphosphatases↗
PubMed1997

Infant mortality and low birthweight, 1975 to 1995.

OBJECTIVES: This article examines trends in infant mortality and the incidence of low birthweight from 1975 to 1995. DATA SOURCES: The data are from the Canadian Vital Statistics Data Base, compiled from information provided to Statistics Canada by the Vital Statistics Registries in each province and territory. ANALYTICAL TECHNIQUES: Death rates, stillbirth rates, and the incidence of low birthweight were calculated for Canada, the provinces, and territories from 1975 to 1995. To examine the impact of changes in maternal characteristics during the period, the incidence of low birthweight was standardized by age and marital status of mothers, using the 1985 distributions. MAIN RESULTS: The pace of decline in infant and perinatal mortality has slowed in recent years. This slowdown may, at least in part, be attributed to the increase in the incidence of low birthweight. In turn, some of the increase in the incidence of low birthweight is explained by the rising proportions of births to women aged 35 and older and to unmarried women.

Adolescent↗
PubMed1996

Projecting interregional migration balances within a multiregional cohort-component framework.

"The main themes of the paper are developed in three parts. First, the setting for the study is established by reviewing the foundational theory of multiregional population projections, and by detailing how interregional migration is projected within this approach. Second, we will identify the requirements for making multiregional population projections in Canada and undertake to explain why the conventional approach to projecting interregional migration produces less than satisfactory results. Third, an alternative method for projecting interregional migration is proposed."

Americas↗
PubMed1996

Changing fertility patterns, 1974 to 1994.

From 1974 to 1994, the number of children Canadian women are likely to have during their lifetime decreased. This downturn in fertility meant that the annual number of live births rose only slightly during this period, even though it marked the prime childbearing years for the baby-boom generation. As they pursued higher education and employment in the paid workforce, women have postponed childbearing. Consequently, the average age of women giving birth has risen. More than a quarter of women over age 30 who have a baby are first-time mothers. And by starting families later in life, women tend to have fewer children. In addition, largely because of the growing number of common-law relationships, over a quarter of all births are to unmarried women. Using data provided by the provincial and territorial Vital Statistics Registries, this article examines national and provincial/territorial trends in births and fertility from 1974 to 1994.

Adolescent↗
PubMed1996

Twenty years of marriages.

In 1994, a total of 159,959 marriages were performed in Canada, up only slightly from 159,316 the year before. This small increase had no effect on the crude marriage rate, which remained at 5.5 marriages per 1,000 population. Aside from a brief uptum in the late 1980s, Canada's marriage rate has fallen quite steadily since the early 1970s. The overall decline is also evident when rates are disaggregated by the prior marital status of the bride and groom (single, divorced or widowed). Since 1974, the average ages of brides and grooms have risen about five years to 30.1 and 32.6, respectively. Nonetheless, the peak ages for marriage are the twenties. In this age range, women's marriage rates exceed those of men, but at older ages, men's rates are higher. And at progressively older ages, a growing proportion of grooms have brides at least 10 years their junior. The marriage patterns of Quebec residents differ from those of other Canadians. Quebec residents are much more likely to remain single or live common-law, and if they do marry, they are slightly more likely to divorce. Once divorced or widowed, people in Quebec are less likely than those in the rest of Canada to remarry. This article is based on data compiled by Statistics Canada from marriage registration forms provided by the central Vital Statistics Registry in each province and territory.

Adult↗
PubMed1995

Deaths 1993.

Explore the source record for details and available documents.

Adolescent↗
PubMed1995

Interprovincial data requirements for local health indicators: the British Columbia experience.

Indicators based on the registration of vital events are used to determine the health status of populations. The need for these indicators at the regional and community levels has grown with the trend toward decentralization in the delivery of health services. Such indicators are important because they affect funding and the types of service that are provided. Health status indicators tend to be associated with variables such as the level of urbanization or socioeconomic status. According to four indicators-mortality ratios for all causes of death, mortality ratios for external causes of death, infant mortality ratios, and low birth weight live birth ratios-some areas of British Columbia, specifically along the border with Alberta, have relatively good health, although the characteristics of these regions suggest that this should not be the case. However, a much different picture emerges when vital event data registered in Alberta for residents of these areas of British Columbia are considered. This article shows that for adequate health planning and program implementation, some communities need data from neighbouring provinces. It illustrates the effect of incorporating Alberta data into the development of health status indicators for British Columbia. It also suggests that similar adjustments may be necessary for data compiled in other provinces.

Adolescent↗
PubMed1991

Effects of fertility and international migration on changing age composition in Canada.

"This paper analyses the prospects for age distribution in Canada through 2036, based on today's age structure and expected trends in fertility and international migration. Simulating these two demographic components at extreme levels shows that tomorrow's aging is already built into the current age distribution, which is heavily marked by the post-war baby boom and the following persistent baby bust, and that neither fertility nor immigration can be seen as effective adjustment mechanisms for the changing age composition of Canada. Population projections using the component method are applied along with an age-specific growth-rate analysis."

Age Distribution↗
PubMed1990

[Aging and education of the Quebec population].

"Having projected the composition of the population of the province of Quebec for the years 2011 and 2031 with respect to level of education, the author suggests ways in which an increase in the overall level of scholastic attainment could help Quebec meet the challenge of an aging population. According to him, a better educated population would be more productive and less dependent on public finances when it reached retirement. Such a population would cost less in terms of health care and could, if needed, remain in the labor force past retirement age." (SUMMARY IN ENG AND SPA)

Americas↗