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F N Judson

Publications and source records attributed to F N Judson.

153 records · Page 9Linked to original sources
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A clinical isolate of Neisseria gonorrhoeae with in vitro resistance to erythromycin and decreased susceptibility to azithromycin.

BACKGROUND AND OBJECTIVES: Erythromycin is a recommended treatment for penicillin-allergic pregnant women with gonorrhea, and azithromycin has been suggested as therapy for coexisting gonococcal and chlamydial infections. Although gonococcal resistance to erythromycin is not uncommon, decreased resistance to azithromycin is rare. A clinical isolate of Neisseria gonorrhoeae with in vitro resistance to erythromycin and decreased susceptibility to azithromycin is reported. STUDY DESIGN: This is a case report. RESULTS: Antimicrobial susceptibility testing of a clinical isolate of N. gonorrhoeae revealed a minimal inhibitory concentration (MIC) of 2 micrograms/ml to azithromycin and 32 micrograms/ml to erythromycin. Five hundred other urethral isolates were tested, resulting in an MIC for erythromycin ranging from 0.015 to 2 micrograms/ml. The range for azithromycin was 0.015 to 0.5 micrograms/ml. There was a strong correlation between erythromycin and azithromycin MICs (r = 0.73; P < 0.0001). CONCLUSIONS: Continued national monitoring is needed to detect the appearance and early dissemination of new types of gonococcal resistance.

Adult↗
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Epidemiology of sexually transmitted hepatitis B infections in heterosexuals: a review.

The evidence that hepatitis B virus is transmitted between heterosexuals as a result of sexual contact is indirect, incomplete, and depends on definitions. In developed western countries, the highest attack rate for endemic hepatitis B is found in sexually active young adults. Compared to the prevalence among "controls," the prevalences of hepatitis B surface antigen (HBsAg) and/or its antibody are significantly higher in female prostitutes, in women with venereal diseases, and in spouses of patients with hepatitis B. Prospective studies of serosusceptible spouse contacts of persons infected with hepatitis B virus have established secondary attack rates of 20-27%. No study has determined what types of heterosexual contact lead to infection or the risk of infection from a single sexual encounter. The highest concentration of HBsAg is found in blood, but HBsAg also appears in saliva, semen, menstrual discharge, vaginal secretions, feces, urine, and tears. Although HBsAg-positive blood transmits infection to humans when given by mouth and injections of HBsAg-positive human saliva will transmit hepatitis B virus to gibbons or chimpanzees, the epidemiologic importance of saliva and other secretions and excretions in transmitting hepatitis B virus during sexual contact is unknown. Hepatitis B vaccine may be indicated for preexposure prophylaxis of serosusceptible heterosexuals at high risk hepatitis B.

Adult↗