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Biomedical subjects

F N Judson

Publications and source records attributed to F N Judson.

At least 127 records · Page 7Linked to original sources
PubMed1976

Tetracycline in the treatment of uncomplicated male gonorrhea.

A clinical trial was performed to test a loading dose regimen of tetracycline (1.5 gm po sTAT and 0.5 mg po quid for 4 days) against a no-loading dose (0.5 gm po quid for 4 1/2 days) in the treatment of 477 cases of uncomplicated male urogenital gonorrhea. The regimens were equivalent, with an overall cure rate of 96%. A crossover pharmacokinetic study in 10 healthy volunteers demonstrated higher blood levels during the first day on the loading regimen, but equivalence thereafter. Tetracycline, in a total dose of 9.5 gm, is highly effective treatment, and a loading dose is not necessary.

Adult↗
PubMed1975

Epidemic acute infectious nonbacterial gastroenteritis at the Children's Asthma Research Institute and Hospital.

During the period from September 8 to October 2, 1970, 44 of the 120 children and 78 of 141 adults questioned at the Children's Asthma Research Institute and Hospital experienced gastroenteritis characterized by nausea, vomiting, and fever and/or chills. Diarrhea was rare in children (4.5%) and common in adults (74%). The median duration of illness for children, 18 hours, was significantly shorter than the 48 hours for adults. All viral and bacterial cultures of 30 stool specimens were negative for viruses and bacterial pathogens. A retrospective survey of 28 ill employees revealed a secondary attach rate of 46% of 76 family contacts. A bacteria-free filtrate prepared from stool swab specimens of 2 ill adults by a team at the National Institute of Allergy and Infectious Diseases was administered orally to 3 adult volunteers. One of the 3 vomited and had 4 watery diarrheal stools on the third post-inoculation day. Diarrheal stool filtrates from this person were then given orally to 8 others; 1 became ill. Although the epidemiologic features point to the respiratory route of infection, the probably successful serial transmission of disease via bacteria-free stool filtrates through 2 generations of volunteers also suggests that the "Denver agent" is a virus-sized particle that replicates in the gastrointestinal tract.

Acute Disease↗
PubMedDate not supplied

Tobacco use and other risk behaviors among adolescents in an STD clinic.

BACKGROUND: This study examined the potential for tobacco use and other health risk behavior interventions in the context of an urban sexually transmitted diseases (STD) clinic. METHODS: A cross-sectional survey of two populations. Adolescents seen at an STD clinic or at the teen clinic of a community health center completed a self-administered computer survey in 1996. Risk behaviors, attitudes, and readiness to stop smoking were analyzed for 225 patients at the STD clinic and 248 patients at the teen clinic. RESULTS: Compared with adolescents in the teen clinic, adolescents in the STD clinic were more likely to have smoked frequently (OR 1.7, 95% CI 1.1, 3.0), used any illegal drug (OR 2.7, 95% CI 1.3, 5.5), recently binged on alcohol (OR 1.7, 95% CI 1.0, 2.8), and had more than 10 lifetime sexual partners (OR 1.9, 95% CI 1.0, 3.4). Weapon carrying, readiness to stop smoking, and attitudes toward smoking did not differ between sites. CONCLUSIONS: Cigarette smoking and other health risk behaviors are more prevalent among adolescents in an STD clinic than among adolescents in a community health center. STD clinics are potential sites for cigarette, alcohol, and drug use interventions among "hard to reach" adolescents.

Adolescent↗
PubMedDate not supplied

An evaluation of the microcult gonorrhea detection system.

The Microcult Gonorrhea Detection System employs a dehydrated selective medium adsorbed into a cellulose matrix. The medium is rehydrated before use, then incubated in a foil pouch with a tablet that releases carbon dioxide. Duplicate specimens were plated in parallel on modified Thayer-Martin media and Microcult media. In all, 131 urethral specimens which contained gram-negative intracellular diplococci, 311 cervical specimens and 308 anal specimens were studied. Gonococci were isolated on modified Thayer-Martin media from 128 urethral, 63 cervical, and 29 anal specimens. In contrast 109 urethral, 48 cervical, and 5 anal specimens were shown to contain gonococci using the Microcult system. The Microcult system is inferior to fresh modified Thayer-Martin media for detecting gonococci.

Anal Canal↗
PubMedDate not supplied

A rational basis for the epidemiologic treatment of gonorrhea in a clinic for sexually transmitted diseases.

Epidemiologic treatment of gonorrhea refers to the administration of antibiotics when the diagnosis is considered likely, but before the results of confirmatory tests are available. Unfortunately, the risk of infection is seldom known. To place epidemiologic treatment on a more rational basis, infection rates were determined for groups of clinic patients defined by easily collected indexes of risk such as reason for attending the clinic, sex, race, and sexual preference, history of contact with gonorrhea, and history of a urethral or vaginal dischange. Infection rates ranged from 0.8% for men seeking marriage licenses to 65.1% for female contacts of men with "established" gonorrhea. By selectively employing gram-stained smears, it is possible to reduce further the need for epidemiologic treatment within the various defined groups of patients. Epidemiologic treatment policies should be determined by each large clinic and should be based on known infection rates for clearly defined groups of patients. Such rates are necessary for obtaining informed consent from patients and for evaluation of the cost-effectiveness of epidemiologic treatment in the overall effort to control gonorrhea.

Colorado↗
PubMedDate not supplied

A clinic-based system for monitoring the quality of techniques for the diagnosis of gonorrhea.

The author describes a clinic-based system that monitors the quality of techniques for diagnosis of gonorrhea by continuous comparison of the results of gram-strained smears of urethral and cervical specimens with the corresponding cultures. Discrepant results are immediately reviewed. During a two-year period, the system detected two defects in culture incubation, visual defects in a laboratory technician, and three unexplained reductions in cultural sensitivity. The system motivates clinicians and laboratory technicians to maintain a high level of quality control. In 11,474 comparisons of urethral smear and culture results, there was agreement in 96.9% while the smear alone was positive in 1.6% and the culture alone in 1.5%. Review of positive-smear-negative-culture discrepancies indicated that most smears judged "false-positive" were so classified on the basis of false-negative cultures. In study of 1,331 women, the endocervical smeras identified 60% (273/455) of those with positive culture discrepancies. Many of these may have represented false-negative cultures.

Clinical Laboratory Techniques↗
PubMedDate not supplied

Strategic planning system for control of venereal disease: record keeping in a clinic for treatment of sexually transmitted diseases.

A manual data processing system and a computer-based system that was integrated into the operations of a clinic for treatment of sexually transmitted diseases were developed. The automated system can generate routine management reports and cross-tabulate data for special studies. It is flexible and adaptable to other localities but is not a panacea for clinical problems.

Centers for Disease Control and Prevention, U.S.↗
PubMedDate not supplied

Intensive screening for gonorrhea, syphilis, and hepatitis B in a gay bathhouse does not lower the prevalence infection.

An attempt was made to reduce the rate of infection with Neisseria gonorrhoeae among homosexual men who visit a bathhouse in Denver, Colorado, by the offer of screening cultures during the 24 hr per week of maximal use of the bathhouse. A total of 543 men were screened (646 tests). The rate of infection did not decline significantly (P less than 0.80) from the first month (31 of 272 men; 11.4%) to the third month (19 of 180 men; 10.6%) of the program. Early syphilis was detected in five (0.8%) of 606 men and hepatitis B surface antigen in 13 (3.3%) of 389 men tested. Serologic evidence of prior infection with Treponema pallidum and hepatitis B virus was found in 96 (19.3%) of 498 and 226 (58.1%) of 389 men tested, respectively. It was concluded that patrons of a gay bathhouse have a high risk of contracting gonorrhea, syphilis, and hepatitis B. Although intensive screening is a cost-effective method of detecting cases of gonorrhea, the screening program did not reduce the prevalence of infection.

Gonorrhea↗