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Biomedical subjects

F Mora

Publications and source records attributed to F Mora.

At least 181 records · Page 10Linked to original sources
PubMed1976

Effects of dopamine-receptor blockade on self-stimulation in the monkey.

In a dose-response experiment it was shown that intraperitoneal injections of 0.062 mg/kg, and 0.1 mg/kg of the dopamine-receptor blocking agent and neuroleptic spiroperidol severely attenuate self-stimulation in the orbitofrontal cortex, hypothalamus, and in the region of the locus coeruleus, in the rhesus monkey and in the squirrel monkey. In the rhesus monkey intracranial injections of 6 mug of spiroperidol bilaterally into the nucleus accumbens or the hypothalamus attenuated self-stimulation of the amygdala, and injections into the orbitofrontal cortex attenuated self-stimulation of the amygdala and lateral hypothalamus. Self-stimulation at other sites tested (including the region of the locus coeruleus) was much less affected by the injections, and injections into the region of the locus coeruleus were ineffective. These results together with other control experiments suggest that spiroperidol can attenuate self-stimulation in the monkey independently of any motor impairment or sedation produced, and that dopamine receptors in particular brain regions are involved in self-stimulation of particular brain sites.

Animals↗
PubMed1976

[Ceruloplasmine in schizophrenic and in epileptic patients (author's transl)].

Ceruloplasmine was measured in serum of normal, schizophrenic and epileptic patients through the use of oxidase and immunological methods. The measurements were correlated to find: the reliability of oxidase method as an index of ceruloplasmine concentration and the immunological identity of this protein in the three groups of individuals. The results showed that the oxidase method served as a good index of ceruloplasmine concentration in the sera and that an immunological identity among the three groups exised. A significant correlation between the serum oxidase activity and the ceruloplasmine immunological determination was, further, observed.

Ceruloplasmin↗
PubMed1976

[Immunological and oxidase measurement of ceruloplasmin in pregnant women and newborn (author's transl)].

Ceruloplasmin measurements were made by oxidase and immunochemical methods in serum from three groups of people, normal, pregnant women and their newborns. Whatever the method ceruloplasmin showed a decrease in the newborns and an increase in pregnant women as compared with the normal controls. The three groups showed a significant correlation between both measurement. The correlation ratio between the two methods of measurement in the newborns is significantly different from the pregnant and the normal groups. It appears that ceruloplasmin in the newborns' serum has a lower oxidase activity per molecule than that from adult's serum.

Ceruloplasmin↗
PubMedDate not supplied

Is neurotensin in the brain involved in thermoregulation of the monkey?

Cannulae for intracerebroventricular (ICV) infusion were implanted stereotaxically in monkeys (Macaca fascicularis) maintained post-operatively in a primate restraint chair. During each experiment, a series of physiological measures was recorded simultaneously on a polygraph which included colonic temperature, vasomotor tone, heart rate, respiratory rate, and basal metabolism as reflected by O2 uptake. The ICV infusion in a volume of 0.5 ml of neurotensin (NT) in doses ranging from 3-150 micrograms produced neither a statistically significant nor consistent change in body temperature or vasomotor response. Although the highest dose of 450 micrograms NT infused ICV caused an immediate bradycardia and a concomitant decline in metabolic and respiratory rates, an average decline in core temperature of 0.6 degrees C and the accompanying cutaneous vasodilation often had a latency as long as 1.0 hr. In contrast to the typical hypothermia in this species following an ICV infusion of catecholamines, implicated in the central pathways underlying thermoregulation, NT failed to elicit a coordinated set of physiological responses for heat dissipation in the monkey. Therefore, it is unlikely that this tridecapeptide plays a role in the central mechanisms mediating the control of body temperature of this primate species.

Animals↗