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Biomedical subjects

F Monaco

Publications and source records attributed to F Monaco.

188 records · Page 11Linked to original sources
PubMedDate not supplied

[Optokynetic and ocular dysmetria tests in the diagnosis of atypical internuclear ophthalmoplegia (author's transl)].

In a patient with atypical bilateral internuclear ophthalmoplegia the optokynetic test and the ocular dysmetria test detected an infraclinical bilateral lag of adduction. The optokinetic test showed amplitude asymmetry of nystagmus, which was larger in both eyes when the fast phase was in abduction. The ocular dysmetria test showed in both eyes that saccades were slower in adducting than abducting saccades: the latters overshooted and showed transient nystagmus. Since bilateral internuclear ophthalmoplegia is often indicative of multiple sclerosis, these tests are particularly helpful in those patients who otherwise would require more complex diagnostic investigations.

Adult↗
PubMedDate not supplied

[Importance of the specific surface area in the study of the biological effects of dusts of industrial use].

We have studied a sample of commercial sepiolite and two samples of commercial vermiculite which are advised to replace asbestos, and we have in vitro tested their abilities to activate the complement and to lyse erythrocytes. Their behaviours has been compared with those of asbestos fibres given by Union Internationale Contre le Cancer (UICC) as reference standards. We have first measured the specific surface area and the weight of each mineral. Sepiolite has been inactive in complement activation and little able to lysis red blood cells on the base of surface area; on the base of the weight it has been unreactive in complement activations but very reactive in red blood cells lysis. We believe that in the in vitro assays to evaluate the biological effects of the substitutes of asbestos it is very important to considerate as the weight and as the specific surface are of each clay mineral.

Aluminum Silicates↗
PubMedDate not supplied

[Acrylonitrile and chemotaxis: in vitro experiments].

We have verified that chemotaxis of isolated human polymorphonuclear leukocytes (PMN) was a target of in vitro toxicant effect of acrylonitrile (ACN). This toxicant induced a significant dose dependent decreasing of chemotaxis with 50% inhibition (IC50) occurring at 15 mM. We assume that PMN from workers exposed to ACN reacts vivo in a similar way to PMN exposed in vitro to ACN. We propose therefore to use chemotaxis assay as a biomarker of early biological effect of ACN in workers, since for their monitoring there are so far only internal dose indicators but no suitable effect indicators.

Acrylonitrile↗
PubMedDate not supplied

[Effect of carbamazepine on free and protein-bound tryptophan in the blood of epileptic patients and healthy volunteers].

The Authors estimated the influence of carbamazepine on both free and linked albumin triptofane in the plasma of 6 epileptic patients and of 6 healthy volunteers, during a period of observation lasting 7 days. The relation free/linked triptofane decreased significantly in the epileptic patients after the first day of treatment, while an analogous phenomenon was observed in healthy people only after the seventh day. Part of triptofane disappeared from plasma thus suggesting a cerebral uptake of the synthesis of serotonin. Carbamazepine displaced some unknown compounds from their links with plasmatic albumin, thus allowing triptofane to link itsel. The Authors therefore confirm the role played by anticonvulsive drugs in modifying the pool of free aminoacids in plasma.

Adolescent↗