Search PubMed⌕ Search

Biomedical subjects

F Moesgaard

Publications and source records attributed to F Moesgaard.

At least 55 records · Page 3Linked to original sources
PubMed1987

Cell-mediated immunity assessed by skin testing (Multitest). I. Normal values in healthy Danish adults.

The Multitest CMI system consists of a disposable multiple puncture device that simultaneously applies seven standardized recall antigens for assessment of cell-mediated immunity (CMI). The seven antigens included were toxoid from Clostridium tetani and Corynebacterium diphtheriae, tuberculin, plus antigens from streptococcus (group C), Candida albicans, Trichophyton mentagrophytes, and Proteus mirabilis. A population of 352 healthy Danish adults, aged between 17 and 90 years, was tested to determine the incidence and size of delayed-type hypersensitivity (DTH) responses. All but six healthy adults (98%) responded to one or more antigens, the median number of positive responses being four in males and three in females. The incidence of positive responses ranged from 91% for tuberculin to 11% for trichophyton. The number of positive responses declined with age, being somewhat faster in females than males. Six of the seven antigen response rates were significantly lower in the over 65-years-olds, the only exception being trichophyton, and for four of the seven antigens significantly lower in females compared to males. When correlated to age and sex no major differences were found with regard to the size of response to the seven antigens except that the tuberculin response was larger in males. A scoring system based on both number and size of positive responses revealed significant age and sex related differences. The median "score" in 17-65-year-old males and females were, respectively, 17 mm and 14 mm compared to 13 mm and 8 mm in those over 65 years old (P less than 0.001 for both comparisons).

Adolescent↗
PubMed1986

Treatment of abscesses in the vulva. Conventional open treatment versus primary suture under antibiotic cover.

Seventy patients were treated for a subcutaneous abscess in the vulva. In 35 consecutive patients the abscess was treated conventionally with deroofing of the abscess and wet dressings. In the other 35 consecutive patients the abscess was treated by incision, curettage and primary suture under antibiotic cover with a single dose of clindamycin. In the conventionally treated group the median stay in hospital was 7 days and the median healing time 18 days. In the group treated by primary suture the median stay in hospital was 2 days and the median healing time 7 days (P less than 0.0001). Recurrence of abscess was observed in one patient in each group. No other complications were observed in either group. It is concluded that vulvar abscesses may be treated safely and advantageously by primary suture under antibiotic cover.

Abscess↗
PubMed1986

Surgical treatment of ureteric stones.

638 patients with ureteric stones have been evaluated. 174 patients (28%) were selected for surgical treatment. 129 out of the 174 patients initially underwent open surgery. In the other 45 patients the initial treatment was stone extraction by the Dormia technique after which 27 stones were removed successfully. In the remaining 18 patients catheterisation of the ureter was performed, after which stones passed spontaneously in 15 patients. In one patient the stone was removed by another attempt with the Dormia procedure and two patients underwent operation. At follow-up 4-6 weeks after the diagnosis of ureteric stones was made, no signs of stones were found by urography in either the 464 patients (72%) who never underwent any surgical procedure or in the patients treated by open surgery or other procedures. It is concluded that parameters such as degree of ureteric obstruction, infection, pain and stones not passed within 6 weeks are important factors in selection of patients for operation.

Adolescent↗
PubMed1986

Liposarcoma of the stomach. A case report.

A liposarcoma of the stomach, comprising one-tenth of the total body weight and judged to be inoperable, was radically removed in a 15-year-old boy. Liposarcomas rarely affect the gastrointestinal tract, especially the stomach. The three previously reported cases of liposarcoma of the stomach are also reviewed.

Adolescent↗
PubMed1985

Controlled clinical trial of treatment with cimetidine for non-ulcer dyspepsia.

The effect of cimetidine (1 g daily) and placebo was studied in a controlled clinical trial comprising 50 patients with non-ulcer dyspepsia in whom an organic abnormality responsible for the dyspeptic symptoms was not disclosed by a standardized and extensive examination programme. Reduction of symptoms occurred in 13 (54%) out of 24 patients treated with cimetidine and in 16 (62%) out of 26 treated with placebo. The difference was insignificant, as were the alterations in the individual dyspeptic symptoms between the groups. Only 6 patients (25%) on cimetidine and 8 (31%) on placebo treatment had a total relief of symptoms. Of these, all cimetidine-treated patients remained free from symptoms during the successive 3-month observation period, while the dyspeptic symptoms relapsed in 3 (38%) placebo-treated patients. Subsequent resumption of placebo treatment reduced the symptoms in all 3 patients, but only one became free from symptoms. Cimetidine does not seem to be superior to placebo in the treatment of non-ulcer dyspepsia in patients without any previous history of ulcer or without any sign on endoscopy of an active or previous ulcer disease.

Adolescent↗
PubMed1984

Wound infection rates after intraincisional plus systemic antibiotic prophylaxis in an animal model.

The effect of intraincisional application of antibiotics in addition to systemic antibiotic prophylaxis was evaluated in a randomized blind study using a guinea pig model of surgical wound infection. Wounds were contaminated with 10(7) Escherichia coli plus 10(8) Bacteroides fragilis. Wound infection was defined as accumulation of pus draining spontaneously or after opening the wound. Systemic antibiotic prophylaxis with gentamicin plus clindamycin significantly reduced the wound sepsis rate from 83% in the control group to 20% in the treated group (p less than 0.001). Intraincisional application of antibiotics in addition to systemic prophylaxis did not further reduce the rate of wound sepsis (p greater than 0.8).

Animals↗
PubMed1984

Wound infection rates following preoperative versus intraoperative commencement of antibiotic prophylaxis.

The effect of antibiotic prophylaxis initiated one hour prior to contamination or at the time of contamination was evaluated in a randomized blind study using a guinea pig model of surgical wound infection. Would infection, defined as accumulation of pus draining spontaneously or after opening of the wound, developed in 135 guinea pigs after intraincisional contamination before wound closure with 10(7) Escherichia coli plus 10(8) Bacteroides fragilis. Antibiotic prophylaxis with gentamicin plus clindamycin significantly reduced the wound sepsis rate from 82% in the control group of 61 animals to 19% in the two treated groups of 68 and 67 animals (p less than 0.001). However, the timing of antibiotic prophylaxis did not influence wound sepsis rates, rectal temperature during the postoperative period, or bacterial recovery from wound infections.

Animals↗
PubMed1984

Intraincisional antibiotics in laparotomy wounds.

Concentrations of ampicillin after intraincisional instillation in laparotomy wounds were measured in ten patients undergoing appendectomy. Ampicillin, 1 gm, was instilled under the fascia and 1 gm in the subcutaneous space during wound closure. Wound secretion was collected every two hours during the first 24 postoperative hours by cannulation of a fine perforated drain placed in the subcutaneous space. Ampicillin was determined by a disk diffusion method. During the first eight hours the median concentration of ampicillin in wound secretion exceeded 1000 microgram/ml; 14 hours and 20 hours after wound closure the median concentrations were 73 and 14 microgram/ml, respectively. The effect of ampicillin in high concentrations on "resistant" strains of Bacteroides fragilis was demonstrated in an in vitro experiment. It is concluded that in colorectal surgery the effect on wound sepsis of intraincisional antibiotics as an addition to systemic antibiotic prophylaxis should be evaluated in a clinical trial.

Administration, Topical↗
PubMed1984

Early reclosure versus conventional secondary suture of severe wound abscesses following laparotomy.

The study comprised 81 consecutive cases of severe incisional abscesses following laparotomy during a 28-month period. Severe incisional abscess was defined as wound infection necessitating opening of the entire wound down to the fascia. During the first 12 months of the study period, 30 patients had conventional secondary suture with a median time of 12 days from drainage of wound abscesses until closure of clean and granulating wounds. During the last 16 months, 51 patients had early closure of contaminated wounds 4 days after drainage under systemic antibiotic cover with clindamycin. The surgical technique used in early closure allowed complete occlusion of the wound cavity without sutures in the wound itself. Recurrent incisional infection occurred in 3 of 30 patients having secondary suture and in 1 of 51 having early reclosure. It is concluded that early reclosure under systemic antibiotic cover is a safe procedure, which reduces hospitalization and convalescence.

Abscess↗
PubMed1984

A modified technique for stapled anastomosis after the Hartmann procedure.

In 15 patients the intestinal continuity after Hartmann's operation was restored by a stapling technique which facilitates anastomosis without mobilization of the 'blind' rectal stump. No signs of anastomotic leak was observed, and at follow-up 6-12 months later there were no strictures.

Acute Disease↗