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Biomedical subjects

F Mochizuki

Publications and source records attributed to F Mochizuki.

At least 55 records · Page 3Linked to original sources
PubMed1989

[Superselective angiography of the cystic artery for diagnosis of gallbladder diseases].

Superselective angiography of the cystic artery was attempted with 18 patients for the purpose of improving angiographic diagnosis of gallbladder diseases. The success rate of cystic angiography using a fine catheter (5 Fr. size) and a specially coated guidewire was 72% (13/18). In comparison with usual hepatic angiography findings obtained by cystic angiography proved easier to evaluate, because the angiograms thus obtained avoided visualization of the hepatic artery and showed good opacification of the fine branches of the cystic artery. It is concluded that angiographic diagnosis of gallbladder diseases can be improved by use of superselective cystic angiography.

Angiography↗
PubMed1988

[Levels of circulating tumor-associated glycoprotein (TAG-72) in patients with carcinoma using a novel tumor marker, CA 72-4].

CA72-4 is a novel quantitative immunoradiometric assay system utilizing two monoclonal antibodies CC-49 and B72.3, which recognize a tumor-associated glycoprotein (TAG-72). We have utilized the CA72-4 RIA kit to measure serum levels of TAG-72 in 205 patients with carcinoma and 192 patients without carcinoma. The cut-off value (4.0 U/ml) was obtained according to the levels and the distribution of CA72-4 in 468 healthy individuals. The positive rates in 82 patients with gastric cancer, 55 with colorectal cancer, 24 with pancreatico-choledochal cancer, 36 with breast cancer, and 3 with ovarian cancer were 52%, 55%, 46%, 39%, and 67%, respectively. Fifty percent of the sera from 205 patients with carcinoma demonstrated increased levels of CA72-4, whereas only 10% of the sera from 192 patients without evidence of malignancy showed levels more than 4.0 U/ml. The average level of serum CA72-4 in the patients with carcinoma was 38.6 U/ml, much higher than that (2.7 U/ml) in patients without malignancy. The patients with gastrointestinal cancer at advanced stages or at recurrence showed higher levels of serum CA72-4 than the patients with cancer at early stages. These results thus indicate that CA72-4 is clinically useful as a novel tumor marker, especially for monitoring serum levels of TAG-72 in patients with gastrointestinal cancer, breast cancer, ovarian cancer and other epithelial malignancies.

Antigens, Neoplasm↗
PubMed1983

[Case of three peculiar tumors of gastric epithelioid leiomyosarcoma, retroperitoneal paraganglioma and pulmonary chondroma].

A 27-year-old woman with an unusual combination of three independent tumors, gastric epithelioid leiomyosarcoma, retroperitoneal paraganglioma and pulmonary chondroma is reported. There are 15 similar cases collected by Carney (1979) from the literature; ours is the first Japanese case. Patients with this tumor triad tend to be young females, all were of blood group A. The prognosis of these patients is generally good without associated systemic hypertension. Our patient is well 18 months after surgical removal of the three tumors.

Adult↗
PubMed1977

Observations on benign gastric ulcer simulating gastric carcinoma.

We have re-evaluated over-diagnosed cases which were first diagnosed, pre-operatively, as gastric cancer yet later confirmed as benign lesion (excavated lesion, in particular) in the post-operative histological examination of resected stomachs. We have experienced a total number of 1,358 cases which, being detected through mass survey, were diagnosed as cancer and, consequently, operated upon. On the other hand, 61 benign cases were misdiagnosed as cancer, 28 cases being protruded lesions and 33 cases excavated lesions. Among the misdiagnosed cases of excavated lesions, 27 cases were gastric ulcers or their scars, the remaining 6 cases being gastritis or gastric erosion. In 22 out of 33 cases of misdiagnosis, the wrong diagnosis was made by relying solely upon X-ray and endoscopy. Even after the addition of cytology, there were still 9 cases of misdiagnosis. Since, however, biopsy was introduced, there have been only 2 cases of wrong diagnosis. We may safely say that through these findings the absolute necessity of biopsy for the attainment of an accurate diagnosis of early gastric cancer has been sufficiently attested.

Biopsy↗
PubMed1976

Minute gastric cancer.

Nineteen cases of minute early gastric cancer were diagnosed under endoscopical examinations. Diagnosis was established by endoscopic biopsy in 18 cases, and exceptional one case of type IIb was incidentally found. Some of the endoscopic characteristic features of superficial depressed minute cancer were mentioned. By these findings, the diagnosis of superficial depressed minute cancer is possibly made in certain extent only by endoscopic observation. Prognosis of minute gastric cancer is excellent. Especially in the minute early cancer, the actual 7-year-survival rate was 100%. Prognosis of minute advanced cancer is also quite good. Minute gastric cancers can be found clinically and are almost completely curable.

Biopsy↗
PubMed1976

Histo-clinical classification and follow-up study of gastric polyp.

Gastric polyp was found in 1,616 cases or 0.23% of 711,455 persons through the gastric mass-survey. They were classified into 3 groups: hyperplastic polyp in 61%, gastric polyposa in 34%, and polyp composed of metaplastic epithelium with marked atypism (ATP) in 5%. Gastritis polyposa was subclassified into 5 groups according to its histo-clinical features. Malignant degeneration was suspected in 5 or 2.1% of 236 hyperplastic polyps operated, while no polyp which had changed into cancer was experienced among 974 polyps followed-up by biopsy during the time course of 6 months to 11 years at the longest. On the other hand, coexistence of gastric cancer was found in 13% of cases with ATP. In polyps composed of metaplastic epithelium, there are two kinds of polyp: metaplastic polyp in hyperplastic proliferation and neoplastic polyp. In the follow-up study of 1,104 polyps, the growth of polyp was seen in only 14, and 12 of which were hyperplastic polyp. No change from gastritis polyposa to hyperplastic polyp was observed. The increase in size in 14 polyps was seen mostly 3 to 4 years after they were found and was always transient. From these results, it is considered that most of gastric polyps clinically detected have already completed their growth.

Biopsy↗
PubMed1976

Endoscopical polypectomy of the gastric polyp with electro-coagulation wire loop.

A forward-viewing fiberscope equipped with two channels was designed for safer and easier gastric polypectomy under endoscopic control using electro-surgical technique. No electrical accident, bleeding, perforation or significant complications were noticed. Mucosal ulcerations at the polypectomy site healed within a month leaving minor scars behind. In 30 cases, U1 II gastric ulcers developed after polypectomy, which healed leaving convergence of mucosal folds behind. Fiberscopic excision of gastric polyps was also useful for establishing a reliable diagnosis of gastric polyp cancer which is sometimes overlooked by routine biopsy procedure. It may be the "perfect biopsy". The patient with gastric polyp who is aware of his own illness and feels uneasy can be released from his anxiety and regain both physical and mental health at the cost of minimal risks of endoscopic polypectomy.

Electrocoagulation↗
PubMed1976

Roentgenological and endoscopic findings of malignant lymphoma.

Roentgenological and endoscopic characteristics of malignant lymphoma of the stomach were studied referring to the gross pathological appearance of the tumors. Based on the results obtained, we classified malignant lymphoma of the stomach into four types, i.e., superficial, ulcer, polypoid and giant fold types.

Endoscopy↗
PubMed1976

Evaluation of mass screening program for stomach cancer.

Particular method and program of mass survey examination of gastric cancer were introduced into Miyagi Prefecture and the results accumulated during the past 14 years are presented. During this period, 1,427 cases of gastric cancer (0.18%), as well as many cases of other diseases of the stomach and duodenum, were found by the mass survey. 450 cases were those of early cancer in which invasion of carcinoma was limited to the mucosa and submucosa. The ratio of surgically confirmed early cancer cases to all the stomach cancer cases was 36.4%. Almost in all cases of early stomach cancer there were neither complaints nor clinical symptoms; that is, they were the cases of so-called preclinical cancer of the stomach. The prognosis after surgery of early stomach cancer was remarkably favorable with a five-year survival rate over 90% and the death rate due to stomach cancer was actually decreased in the surveyed population.

Adult↗
PubMed1976

Extraventricular lesions demonstrated by gastric photofluorographic study.

In a mass survey for diseases of the stomach with photofluography, lesions other than those of the stomach were studied in 85,040 subjects. Gastric lesions were detected in 2.17%, while other lesions were found in 1.97%, giving an approximately similar ratio. Duodenal lesions were found most frequently and in 1.47%, followed by intraabdominal calcification in 0.44%. Among duodenal lesions, duodenal ulcer was seen in 0.14%, and duodenal diverticulum in 0.34%. Among diseases with abdominal calcifications, calcification of lymph nodes was found most frequently and in 0.24%, followed by cholelithiasis in 0.085% and urolithiasis in 0.004%. Lower esophageal lesions were found in 0.05%, in which esophageal diverticulum was the most frequent and found in 0.034%.

Adult↗