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Biomedical subjects

F Misaki

Publications and source records attributed to F Misaki.

At least 19 recordsLinked to original sources
PubMed1978

Fine morphology of the secretory mode of the tetragastrin-stimulated chief cells of human and dog gastric mucosa.

The chief cells of the gastrin-stimulated gastric mucosa of human and dog were observed under a light and electron microscope. Four microgram/kg AOC-tetragastrin were given parenterally by a single shot to a man and three dogs respectively. Pepsinogen in the gastric mucosa increased at the wash-out stage and at the following dynamic equibrium stage of the chief cell secretion cycle after the administration of AOC-tetragastrin. During those stages, the chief cells released zymogen granules intensively. As the main ultrastructural process for releasing the zymogen granules, the emiocytosis in man and the apical cytoplasm dissociation in dog were discussed.

Adult↗
PubMed1978

Endoscopic studies on the minute structures of colonic mucosa in the follow-up observation of ulcerative colitis.

Thirty cases of ulcerative colitis were examined endoscopically by means of magnifying colonoscope with dye spraying method (the combined method), and their minute mucosal structures were classified into four categories endoscopically, which correlated well with the histological findings. By this procedure, it was easy to detect the subsidence of inflammation of the mucosa in the quiescent phase or to reveal the active inflammatory involvement of the bowel. Moreover, inspecting the minute changes of the colonic mucosa detected by the combined method, remission was more correctly decided and rigid control is contributing to the decrease in the recent rate of recurrence of ulcerative colitis.

Adolescent↗
PubMed1978

Serum alkaline phosphatase (Al-Pase) isozyme in gastric and colonic cancer (using a simple thin layer polyacrylamide gel electrophoresis).

Using the simple thin layer polyacrylamide gel electrophoresis, serum alkaline phosphatase could be separated 5 isozyme bands in various digestive diseases, consisting of 54 cases of gastric cancer, 11 of colonic cancer, 12 of hepatoma, 4 of cholangioma, 14 of pancreatic cancer, 81 of benign hepatobilliary diseases, 13 of cancers of other organs and 61 of control. The obtained results were as follows: 1) The electrophoretic analysis of serum alkaline phosphatase showed the specific band remaining at the origin, already reported as "alkaline phosphatase O", in primary and metastatic cancer of the liver and cholelithiasis. On the contrary, alkaline phosphatase O was never found in gastric and colonic cancer without cholelithiasis. On the contrary, alkaline phosphatase O was never found in gastric and colonic cancer without cancerous metastasis to the liver, and it was also inclined to be positive with the progress of liver metastasis among them. 2) Intestinal alkaline phosphatase was usually found in higher frequency in blood group B and O than in the others, and it was apt to disappear in gastric or colonic cancer with an exacerbation of its cancerous lesions. 3) Heat-stable alkaline phosphatase was found in 10% of gastric or colonic cancer, all of which were histologically proved to be well differentiated adenocarcinoma.

Adenocarcinoma↗
PubMed1977

Estimation of serum acid proteases at pH 1.8 and pH 3.5 in patients with duodenal ulcer, gastric ulcer and gastric carcinoma.

Using a simple hemoglobin method on the basis of Anson-Mirsky's method, acid protease levels in serum were measured at pH 1.8 (pepsin) and pH 3.5 (gastricsin) in 18 healthy controls and 14 patients with duodenal ulcer, 19 patients with gastric ulcer and 18 patients with gastric cancer. Though acid protease activity in pH 1.8 in duodenal ulcer has a tendency to show a little higher level than healthy controls, there is no significant difference in acid protease levels between controls and each of three diseases.

Adult↗
PubMed1977

Clinical evaluation of a sonde-type small intestinal fiberscope.

Endoscopic examination using a specially designed sonde-type small intestinal fiberscope (SSIF, Olympus) was performed in 37 patients of our clinic. The improvement of the scope has enabled us to observe the greater parts of the small intestine within a short time and without hazard to the patient. Therefore, with further improvement of this instrument and the insertion technique, we will be able to inspect all parts of the small intestinal mucosa and diagnose the lesions more easily.

Adenocarcinoma↗
PubMed1977

Dynamic aspects of gastric emptying in patients with peptic ulcer according to ulcer stages.

The pattern and the time of gastric emptying were investigated in 38 patients with peptic ulcer and 7 healthy volunteers using the double-sampling method. The pattern of gastric emptying assumed the following three attitudes, that is, exponential (44%), quadratic (29%) and unclassified (27%) pattern. These patterns appeared to depend on the distance from the gastric angle to the pyloric ring measured from X-ray pictures in the upright position. There was no significant difference in the gastric emptying time in patients with peptic ulcer according to its site. During follow-up observations of the same case, the gastric emptying time had a tendency to shorten in patients with duodenal ulcer while it showed no definite variation in patients with gastric ulcer.

Acute Disease↗
PubMed1976

The estimation of gastric secretory capacity by the telemetering method of pH-sensitive radiocapsule.

Using a pH-sensitive radiotelemetering capsule with antimony electrode or glass electrode, the capacity of the gastric acid secretion was determined according to a modified Satveny's method on four healthy controls and 19 patients with peptic ulcer, and it was compared with that from the usual aspiration method. As to the basal condition, acid output couldn't be measured by the telemetering method in most cases because of high pH value in the stomach. There was no definite relation between two methods. On the other hand, acid output from the telemetering after stimulation of AOC-tetragastrin (4 gamma/kg, s.c.) showed a good reproducibility and good correlation with that from the aspiration method (r = +0.86). And the difference between two methods could be explained from the fact that some volume of secreted acid escaped into the duodenum before being neutralized by potassium bicarbonate, and that some of gastric juice remained not aspirated in the stomach.

Adult↗
PubMed1976

New insertion technique in colonoscopy, forming N-loop and using a stiffening cord.

New insertion technique in colonoscopy with a middle length colonscope which is easy to be handled and without guidance of fluoroscopy was reported. Forming a small N-loop at the sigmoid colon, it was easy to pass the sigmoid colon where is one of the most difficult points to pass through. Further, using a differing cord, the sigmoid colon and the transverse colon were easily straightened and no more loop was seen. With this technique, ileocecal area was observed in 26 of 30 cases (86.7%) and its average time for the insertion required only 17.4 minutes. Therefore, with this technique ,it is emphasized that we can easily observed almost all parts of the colonic mucosa and also terminal ileum without the fluoroscopic control.

Colon↗