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Biomedical subjects

F Micheli

Publications and source records attributed to F Micheli.

86 records · Page 5Linked to original sources
PubMed1985

[Piebaldism associated with cancer].

A family in which piebaldism is inherited in a dominant pattern is described. In this kindred the cutaneous signs were associated to a high incidence of cancer. Malignancy usually became apparent in the fourth decade and did not correspond to any fixed histopathologic type. Associated cutaneous alterations were: "cafe au lait" spots in two members and telangiectasias in one. A peculiar distribution of blood vessels in fundus oculi was found in one member. One patient had broad nasal bridge and low implanted ears was found in another. The initial cases were two male brothers who had central nervous system tumours. One had a pituitary adenoma and the other a grade III astrocytoma. As it is important to find biologic markers in familial cancer, we speculate, that may be in this family, the marker could be the cutaneous hypopigmentation. Numerous cutaneous syndromes associated to a predisposition to develop cancer have been described, and may be piebaldism is a new one. More observations are needed to corroborate these findings.

Adenoma↗
PubMed1984

[Cutaneous urostomies: indications, technics, treatments].

The authors study the outer urinary derivations; place the indications to perform urostomies on the basis of the possible pathological situations; describe the technical modalities for every outer derivative operation concerning kidneys, ureters, vesica and urethra, respectively. They, at last, consider the eventual complications of such operations, and report about the therapeutical and prophylactic measures to be taken, with particular attention to the urine collecting devices.

Drainage↗
PubMed1982

Beneficial effects of lisuride in Meige disease.

We studied the therapeutic effects of apomorphine, bromocriptine, and lisuride on the dystonic spasms of two patients with Meige disease. Lisuride, a potent dopamine receptor agonist, and apomorphine had equal efficacy in lessening facial dyskinesia, while bromocriptine had no consistent effect. Lisuride can be an excellent drug in the treatment of this disabling disorder.

Apomorphine↗
PubMedDate not supplied

A combinatorial approach to [1,5]benzothiazepine derivates as potential antibacterial agents.

[1,5]Benzothiazepines are widely used in a number of different therapeutic areas and therefore represent an interesting scaffold for de novo exploration. Recent literature reports suggest their value as antibacterial agents. The present paper reports the exploration of this scaffold for the generation of combinatorial libraries both in solution and on solid phase.

Anti-Bacterial Agents↗
PubMedDate not supplied

Blepharospasm and apraxia of eyelid opening in lithium intoxication.

We present the case of a 72-year-old woman with a history of a bipolar mood disorder chronically treated with lithium. Upon having the dose increased, she developed an acute confusional state accompanied by blepharospasm (BS) and apraxia of eyelid opening. Gait instability with frequent falls, pyramid tract signs, and postural tremor in both hands were also evident. On withdrawing lithium, symptoms remitted within 2 weeks. This patient illustrates that BS and apraxia of eyelid opening may be triggered by lithium overdose. Our case warrants the inclusion of lithium in the list of drugs liable to induce such movement disorders.

Aged↗
PubMedDate not supplied

Hemiballism in a patient with partial motor status epilepticus treated with phenytoin.

A 13-year-old girl developed left partial motor status epilepticus with severe postictal hemiparesis. Magnetic resonance imaging showed a right frontoparietal hyperintense T2 weighted signal. Treated with phenytoin, carbamazepine and phenobarbital, seizures subsided but left choreic-like flinging movements, consistent with hemiballism, presented 2 days later. On phenytoin withdrawal, symptoms gradually remitted with mild residual dystonia at 14 months follow-up. It is speculated that the lesion might have rendered the cortex more susceptible to phenytoin, inducing unilateral toxicity.

Adolescent↗
PubMedDate not supplied

Hemifacial spasm triggered by vasodilators.

Hemifacial spasm features myoclonic-like, paroxysmal, unilateral muscle twitching, attributable to vascular compression at the facial pontine root entry zone. We present the case of an 85-year-old man who presented with idiopathic hemifacial spasm with onset 23 years before. For the last 5 years, he was successfully treated with botulinum toxin injections. However, occasional nitrate intake for precordial pain promptly triggered muscle twitching. Vasodilation may exacerbate not only cases of hemifacial spasm, but even of trigeminal neuralgia, both recognized as neurovascular compressive syndromes.

Aged↗