This project was undertaken to establish if the integral circulation had any effects upon the mechanical behavior of bone. The influence of blood flow in the rabbit tibia on the strain induced at the bone surface when under load was assessed. Recordings were taken from three adult and three immature New Zealand White rabbits which had previously had both their tibiae pinned with modified orthopedic pins. Strain readings were obtained from the exposed mid-shaft of the tibia of both hind legs before, during and after blood flow changes. The loading was static and used to maintain a strain of 250 mu strain in adult animals and 180 mu strain in immature animals prior to variation in blood flow. The blood flow was altered by means of a tourniquet inflated to 80 mm Hg and placed medial to the pinned tibia; it was inflated for a specific time (approximately 40 minutes) during the experimental loading. Reducing the blood flow appeared to alter the strain recorded at the bone surface while the applied load across the pins remained constant. An initial effect when there was reduced perfusion was that the strain increased following a reduction in blood flow. The strain then began to decrease in magnitude on the compressive aspect coincident with release of the cuff to a level below the value of the initial normally perfused bone. Upon return of the blood supply to normal levels following the initial hyperaemic phase, the strain value increased to a value comparable with that of normally perfused bone.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗

PubMedDate not supplied

Xeloda and Taxotere: a review of the development of the combination for use in metastatic breast cancer.

Docetaxel (Taxotere) and capecitabine (Xeloda) demonstrate synergy in pre-clinical studies and both show high single-agent efficacy in metastatic breast cancer patients previously treated with an anthracycline. The two drugs used in combination in a similar group of patients have been evaluated in a randomised phase III trial comparing this combination with single-agent docetaxel. The results of this study indicate the combination arm to be favourable with significantly superior median time to disease progression (6.1 vs 4.2 months, hazard ratio 0.652, p=0.0001), objective response rate and overall survival without a significant increase in the overall incidence of treatment related adverse effects. This combination of docetaxel and capecitabine provides improved survival prospects for patients with metastatic breast cancer. Ongoing studies will provide further data to optimise the scheduling and use of this combination in the future.

Antineoplastic Combined Chemotherapy Protocols↗

PubMedDate not supplied

Their fingers do the walking.

Explore the source record for details and available documents.

Humans↗