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Biomedical subjects

F Matsuo

Publications and source records attributed to F Matsuo.

35 records · Page 2Linked to original sources
PubMed1985

Pilot study of fluzinamide (N-methyl-3-[3-(trifluoromethyl)phenoxy]-1-azetidinecarboxamide) in refractory partial seizures.

We conducted a pilot study of fluzinamide in 15 adults with refractory partial seizures. After a baseline period, fluzinamide was added to the existing regimen of phenytoin and carbamazepine and increased to maximum tolerated dose. Common side effects included dizziness, diplopia, ataxia, headache, nausea, and rash, resulting in patient withdrawal in six cases. Seizures became less frequent in four of the nine patients who completed the 8-week trial.

Adolescent↗
PubMed1984

GENAS: a database system for nucleic acid sequence analysis.

A database system, named GENAS (GENe Analyzing System), for computer analysis of sequence was constructed using Adbis which is a relational database management system (1). GENAS enables us to retrieve any sequence data from EMBL nucleotide sequence data library (2) and readily to analyze them (if necessary, together with private data) by various application programs in a interactive manner. Analysis of structure of replication origin of replicons was demonstrated using this system.

Base Sequence↗
PubMed1984

Effects of SKF525A, phenobarbital, fasting, and carnitine on the anticonvulsant activity and neurotoxicity of valproate in mice.

The anticonvulsant potency of valproate (VPA), as measured by the maximal electroshock seizure model in mice, was improved by pretreatment with the microsomal inhibitor SKF525A and by fasting, but was reduced by chronic phenobarbital pretreatment. Carnitine did not significantly alter the anticonvulsant properties of VPA. These findings suggest that the efficacy of VPA can be improved by factors that alter its metabolic pattern.

Animals↗
PubMed1984

Partial epileptic seizures beginning in the truncal muscles.

3 patients suffered from partial epileptic seizures beginning in truncal muscles on one side. A gross anatomical lesion was demonstrated in the contralateral parietal area in 2. In the third patient, both interictal and ictal EEG features were consistent with an epileptogenic lesion in the similar location. Several factors seem to contribute to the rarity of this variety of partial seizures.

Abdominal Muscles↗
PubMed1981

Recognition of REM sleep in standard EEG.

A practical method to identify REM sleep in a standard EEG utilizing International 10-20 electrode placements is described. Ordinarily, occurrence of REM sleep in a standard EEG indicates an abnormal sleep pattern and warrants further evaluation of sleep disorders.

Adult↗
PubMed1979

Palatal myoclonus and denervation supersensitivity in the central nervous system.

We postulate that palatal myoclonus after infarction of the brainstem or cerebellum, or both, is the manifestation of denervation supersensitivity secondary to lesions involving the dentatorubroolivary system. Two cases of our own and 31 from the English and French literature were analyzed in order to determine the delay between the occurrence of presumed anatomical lesions and the recognition of palatal myoclonus. The intervals varied from 2 to 49 months with the median between 10 and 11 months. The natural history of palatal myoclonus following brainstem infarction seemed consistent with the hypothesis.

Adult↗
PubMed1977

Focal positive spikes in electroencephalography.

Focal positive spikes and sharp waves in clinical EEG are uncommon (about 1.3 per 1,000 EEGs in this series) and encountered chiefly in early life. All of out seven patients suffered from a convulsive disorder. These discharges must be differentiated from 14 and 6 c/sec positive bursts. Atifactual electrical transients with apparent focal positivity must always be ruled out. Whenever focal positive spikes and sharp waves are identified, it is advisable to search for simultaneous focal negative discharges. The literature indicates that focal positive spikes and sharp waves could be classified according to the presumed pathophysiological mechanisms and illustrative patients were described.

Action Potentials↗
PubMed1977

EEG in benign intracranial hypertension.

A retrospective study of standard EEG's obtained from 26 patients with benign intracranial hypertension was done with particular emphasis on the effect of age on the EEG findings. Abnormal EEG's were found in 10 patients, all were less than 20 years of age. Although no consistent pattern of EEG abnormality could be identified, there appears to be a difference between the immature and adult brain in the EEG response to intracranial hypertension.

Adolescent↗
PubMed1975

Electrical phenomena associated with movements of the eyelid.

A series of observations were made on a normal subject, a subject with a non-metallic prosthesis and one with unilateral facial paralysis in order to demonstrate the role of the eyelid in the production of the electrical potential seen during blinking. The findings support the hypothesis that moving the eyelid over the positively charged cornea of an intact ocular globe alters the electrical field around the globe and is therefore responsible for the recorded potentials. The data are consistent with previous findings that the polarity of the potential due to eyelid movement is opposite that due to vertical ocular rotation in the same direction. The potential occurs in the absence of ocular rotation.

Adult↗
PubMedDate not supplied

Evaluation of multiple doses of milacemide in the treatment of senile dementia of the Alzheimer's type.

A multicenter, double-blind, placebo-controlled, parallel group study was conducted to assess the safety and efficacy of three doses of milacemide in the treatment of patients with senile dementia of the Alzheimer type of mild to moderate severity. Patients were randomly assigned to receive one of three dosages of milacemide (400, 800, or 1200 mg/day) or placebo for 4 weeks followed by a single-blind 4-week placebo period. One hundred forty-eight men and women older than 50 years of age were enrolled, and 129 patients completed the study. The differences among treatment groups were not statistically different with respect to total scores on the Alzheimer's Disease Assessment Scale or any items and subscales that were examined, nor were significant differences on the Clinical Global Impression Scale found. Clinically significant increases in liver function tests, specifically aspartate aminotransferase and alanine aminotransferase (AST and ALT), were reported for five of the patients receiving milacemide, requiring their withdrawal from the study.

Acetamides↗