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Biomedical subjects

F Mariani

Publications and source records attributed to F Mariani.

At least 19 recordsLinked to original sources
PubMed1992

Clinical outcome and emotional-behavioural status after isolated coronary surgery.

In order to evaluate clinical and psychosocial results of isolated coronary artery by-pass graft (CABG) we studied 626 consecutive patients, mean age 61 +/- 8 years (86% men), in a follow-up (median: 58 months) with a complete questionnaire about cardiosurgical problems (post-operative vital status, angina relapse, infarction, heart failure, PTCA, redo, PM) and psychosocial variables (mood, irritableness, job satisfaction, hobby satisfaction, family relations, sexual activity, general well-being and work status). Global evaluation improvement of psychosocial variables was found in 71% of patients without cardiac events (group A) and 11% of patients with cardiac events (group B); worsening was found in 2% of group A and 1% of group B; no referred variations in 13% and 2% respectively (p < or = 0.05. Interests (in work, hobbies and sexual activities) demonstrate an improvement in 20% (group A) and 2% (group B); worsening in 12% (group A) and 4% (group B); no variations in 51% (group A) and 11% (group B) (p < or = 0.005). Patients reported a well-being evaluation improvement about 66% in the group returning to work without restriction, 13% in those with limitation, 6% no further working; worse or unchanged well-being evaluation was found in 9% of patients returning to work without restriction, 3% with limitation, 3% no further working (p < or = 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗
PubMed1992

The IgG subclass antibody response to an inhalant antigen (Dermatophagoides pteronyssinus) during the first year of life: evidence for early stimulation of the immune system following natural exposure.

This study investigates the early humoral immune response following natural exposure to an inhalant antigen (Dermatophagoides pteronyssinus) in 36 babies, from birth until 1 year of age. The total IgG and subclass 1 and 4 D. pteronyssinus-specific antibody levels were assayed in sera collected at 7 days, 3 and 12 months by ELISA. After an initial fall, due to the progressive loss of maternal antibodies, an IgG specific response to D. pteronyssinus was seen between 3 and 12 months. This was restricted to the IgG1 subclass when the values at 12 months were significantly higher than those detected at the third month (P less than 0.001, paired t test). No D. pteronyssinus-specific IgG4 antibody was detected in any subject at any of the time points tested. The present study demonstrates that inhalant as well as food antigens are able to stimulate the immune system during the first year of life and that the antibodies produced are of the IgG1 subclass.

Administration, Inhalation↗
PubMed1992

Early immune responses to Dermatophagoides pteronyssinus and atopic predisposition.

Responses to the house dust mite during infancy may be important determinants of asthma in susceptible individuals. This study assessed early IgG subclass antibody responses to Dermatophagoides pteronyssinus in children of atopic parents. Sixteen atopic and 15 non-atopic children were selected from a birth cohort, and atopic status was established according to follow up over the first two years. IgG1 and IgG4 antibodies to D pteronyssinus were measured by enzyme linked immunosorbent assay at 7 days and 3, 6, 12, and 24 months. In all children D pteronyssinus IgG1 fell at 3 months (indicating maternal antibody loss), rose progressively to 12 months, and waned at 24 months. D pteronyssinus IgG4 was only detectable at 7 days. Children who were atopic by 2 years and therefore at greater risk of asthma, tended to have higher D pteronyssinus IgG1 at 6 and 12 months. These data suggest greater exposure or responsiveness to dust mite during infancy than in the second year.

Aging↗
PubMed1992

Treatment of bowel injuries in war surgery.

Provided that the surgeon is familiar with small and large bowel surgery, primary resection and anastomosis of the bowel, as well as primary suture of the perforations, are safe and advantageous procedures in treating war related intestinal perforations, whereas the use of colostomosis should be restricted to selected cases.

Adolescent↗
PubMed1991

Identification of a specific Mycobacterium tuberculosis protein able to activate T lymphocytes.

The recent advances in the field of immunology and molecular biology allow to consider not distant the identification of protective antigens to be used in new prophilactic and diagnostic tools. In our laboratory we have analysed a M. tuberculosis expression library by murine monoclonal antibodies, human sera and human T lymphocytes. We have identified a 35 Kd protein present only on the M. tuberculosis complex (M. tuberculosis, M. bovis, M. africanum). This 35 Kd protein is also detected, by immunohistological analysis, inside the alveolar macrophage of pulmonary tuberculosis patients. Both recombinant beta-galactosidase and MS2 polymerase-fused proteins have been produced and used to perform western blotting and T cell proliferation assay. As the cloned fragment contains an internal EcoRI restriction site, it was possible to identify two fragments of 1.7 and 2.2 kb respectively. Southern blot analysis showed that both the fragments hibridized with the genomic DNA from M. tuberculosis complex but not with the DNA from other mycobacterial isolates from 12 pulmonary tuberculous patients hibridized with the 1.7 kb fragment. The possible use of this insert for the molecular diagnosis of tuberculosis is under investigation.

Animals↗
PubMed1990

[Inhibition by ketotifen of specific skin wheal reaction in atopic subjects].

In order to reconsider the ability of ketotifen (K) to inhibit the specific (allergen-induced) skin wheal reaction (SWR) and the correlated problems, 32 patients, all suffering from seasonal allergic rhinitis due to grass pollens, have been studied. K has been compared with sodium cromoglycate (SCG), which is not metabolized in man. SPT with grass pollen extracts before and after treatment have been performed in all patients, divided into two numerically equal groups treated with either drug at usual dosages for eight weeks. The specific SWR has been significantly inhibited by K, but not by SCG. The theoretical and practical meaning of this finding is discussed.

Adult↗
PubMed1978

[Spinal and spinal cord injuries in aviation medicine].

The causes of vertebral lesions in the course of flying are listed. An account is given of the dynamic forces required to bring about vertebral fracture and their mechanism. Reference is made to the most common sites of vertebral injury in crashes, particularly in the case of helicopters, and during catapulted seat ejection. Lastly, sites of vertebral fracture in parachutists are discussed.

Accidents, Aviation↗
PubMedDate not supplied

[External plastic surgery of the pre-ostial valve in sapheno-femoral junction insufficiency. Experimental studies and clinical cases].

External plasty of the pre-ostial valve is a surgical technique which has the aim of correcting reflux resulting from incompetence of the sapheno-femoral valve and at the time retaining the anatomical structure of the region. The artificial stenosis produced by external valvuloplasty of the pre-terminal valve complex has been studied in physical experiments, the first results of which already appear to be significant. The authors have operated upon 18 patients, with follow-up too short for the presentation of final results, but already sufficient to permit discussion of findings after a short period of time.

Adult↗
PubMedDate not supplied

[Drug dependence].

Explore the source record for details and available documents.

Adolescent↗