Biomedical subjects
Publications and source records attributed to F Mannino.
The therapeutic efficacy of atropine and salbutamol sprays alone or in association was experimented in patients with atopic bronchial asthma as part of an investigation of the bronchodilatatory drugs and the pathogenesis of bronchospasm. As personally observed in other situations, combination of these drugs does not allow their maximum effect to be obtained.
Changes in the flow-volume curve after administration of a bronchodilator were studied in reversible bronchial obstruction. The concept of isovolume is used in analysis of the curve indices, i.e. it is felt that the index (75, 60, 50, 25% FVC) after administration should be fixed on the curve at the same volume as on the basic curve to enable an indirect account to be taken of changes in flow in function of time, since, if resistance is reduced, the emitted volume varies in the same period even though the conditions promoting the flow are unchanged.
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This has been a brief summary of the problems emerging as more community hospitals develop neonatal intensive care, analyzing their possible origins and significance. A description of one solution to the problem has been given, exemplified by an outreach program from the University of California, San Diego, and University Hospital, San Diego, with the community of Las Vegas, Nevada. We feel strongly that the responsibilities of medical schools toward community hospitals and toward regionalization in isolated communities should be unique and are not covered by usual regulations or traditional concepts of regionalization.
The current status of beta-adrenergics in the treatment of bronchospasm is discussed. Personal experience is reviewed with special attention being paid to associations of the drugs on aminophylline, atropine and bechlomethasone dipropionate.
The course of chronic bronchitis is examined with particular stress on the most important clinical and functional factors for the purposes of the prognostic judgment on the disease. Phenomena of reoccurrence of cardiorespiratory insufficiency are also examined.
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