[Vertigo from the internal medicine viewpoint].
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Biomedical subjects
Publications and source records attributed to F Mahler.
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By means of the 3 basic methods of oscillography , ankle pressure determination by Doppler ultrasound, and ergometric exercise testing, most patients with peripheral artery occlusive disease can be adequately evaluated. Thorough non-invasive diagnosis is rewarding, particularly with regard tot he currently available invasive therapeutic methods.
It is not common knowledge that, besides venous thrombosis, arterial thrombotic events may also be associated with the nephrotic syndrome. Two patients are reported who were admitted because of thrombotic occlusions in the peripheral arteries and developed nephrotic syndrome due to membranous glomerulonephritis after various lapses of time. These two cases and the literature support the hypothesis that an identical pathogenetic mechanism may be responsible for the arterial thrombosis as well as the glomerular lesions.
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Fifty-seven patients (34 men and 23 women) underwent percutaneous angioplasty (PTA) of the superficial femoral artery. Follow-up angiography revealed restenoses/reocclusions in 23 patients (relapsing group) and a patent, previously-dilated segment in 34 cases (patent group). These two groups were compared retrospectively regarding their clinical and angiographic state at the time of PTA. The lengths and types of the dilated arterial lesions were similar for both groups. However, the patients in the relapsing group were older as an average, showed significantly more advanced arteriosclerotic disease of their outflow tracts, and were predominantly female. For the relapsing group, a smaller lumen had been attained and a significantly higher brachiopedal pressure difference remained after PTA as opposed to the patients of the patent group. Of the patients with clinical signs of relapse, 28% still had patency of previously dilated segments at follow-up angiography. The true patency rate of dilated arterial segments presumably is higher than what is expected from follow-up examinations using clinical methods alone.
The diameter of nailfold capillaries in conventional intravital microscopy is estimated by measuring th width of the erythrocyte-columns. We determined the diameter of the fluorescence-marked microscopy in 33 capillary loops in the nailfold of 12 subjects and compared it with that of the ec-columns. 400-500 mg FITC-albumin were injected into the brachial artery through cannulas inserted for bloodgas analysis. The FITC-marked capillary lumen exceeded the width of the ec-columns of 10.8 +/- 3.0 microns by 4.2 +/- 0.7 microns or by 38% on the arteriolar side, and that of 12.0 +/- 2.7 microns by 4.6 +/- 0.8 microns (p less than 0.01), on the venular side. Venous occlusion produced a significant enlargement of the ec-columns by 13% (p less than 0.01), but no significant increase in the FITC-marked capillary lumen. The difference of 405 microns between the full capillary lumen as represented by the fluorescent plasma space and the width of the ec-columns corresponds presumably to the plasmatic zone between red cells and the vessel wall. No extravasation of FITC-HA was observed neither before nor after venous occlusion.
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Two cases are reported of toxic shock syndrome in patients with pyogenic arthritis due to Staph. aureus with proven production of enterotoxin F and pyogenic exotoxin C. An ischemic complication of both lower extremities in one of the patients may be related to the use of a heparin-dihydroergotamine combination for postoperative prophylaxis of deep vein thrombosis.
In 59 percutaneous transluminal dilatations (PTD) the coaxial double catheter system was chiefly used, and only in one case was the axillary approach necessary. Clinically relevant complications were 1 dissection of the dilated renal artery (re-dilated successfully) and 2 hemorrhages at the femoral puncture site (1 surgical repair). In 32 patients (follow-up 2-52 months, mean 20 months) blood pressure was lowered from 187/108 to 150/91 mm Hg despite reduced antihypertensive therapy (p less than 0.001). Out of 15 patients with atherosclerotic stenoses blood pressure was normalized by PTD in 2 cases (unilateral) and improved in another 8 cases. Out of 11 patients with fibromuscular dysplasia blood pressure was normalized in 7 cases (all unilateral), improved in 3 and unchanged in 1 (bilateral). Among 6 patients with miscellaneous disease (vasculitis, renal insufficiency) only 2 were improved. Thus, PTD of renal arteries is a useful alternative in the management of renovascular hypertension, mainly in patients with fibromuscular dysplasia, unilateral stenosis and elevated renal vein renin ratio. Long-term results are comparable to the surgical results. However, since no surgical dissection is necessary, morbidity is low and long and costly hospital stays can be avoided. The procedure can be repeated in relapsing cases. For rare complications a vascular surgery team should be available.
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Sixteen consecutive patients with renovascular hypertension were treated by transluminal dilatation and observed during 6 - 39 months (mean 21.8 months). Poststenotic renal artery pressure increased (p less than 0.001) and the renal arteries were patent on angiograms taken immediately after dilatation. In 13 patients, angiography was repeated 2 - 9 months later; at that time the selective renal vein renin ratio had decreased (p less than 0.001). At the end of the follow-up, blood pressure was improved or normal in 14 cases. One of the eight patients with atherosclerosis was normotensive without treatment, compared with five of six patients with fibromuscular dysplasia (p less than 0.05). The results in two cases with vasculitis are uncertain. The four patients with relapses, one after intimal catheter dissection, were treated successfully by redilatation. Thus, renovascular hypertension can be improved by transluminal dilatation in patients with atherosclerosis and in patients with fibromuscular dysplasia with lasting success and a low morbidity rate.
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