Biomedical subjects

F Magni

Publications and source records attributed to F Magni.

121 records · Page 7Linked to original sources

PubMedDate not supplied

Pharmacological activity of bamifylline on lung anaphylaxis: in vitro studies.

Bamifylline, a 7-8 disubstituted theophylline derivative, reduces in a dose dependent way (1 x 10(-5) M, 1 x 10(-4) M and 1 x 10(-3) M) the release of histamine, TXB2 (measured also as TXA2-like material) and SRS-A (as LTD4-like material) during the immunological challenge of actively sensitized guinea-pig lungs perfused in vitro. Theophylline was significantly less potent than bamifylline and particularly, at the higher concentrations used (1 x 10(-3) M), bamifylline was 2.7 times more potent than theophylline in reducing the immunological release of histamine and 1.6 and 1.5 times more potent in inhibiting the production of TXB2 and SRS-A, respectively. These data suggest that the ability of the two xanthine derivatives to control the immunological release of histamine represents an important point in understanding the mechanism of their anti-anaphylactic activity.

Anaphylaxis↗

PubMedDate not supplied

In utero partial liver resection in the rabbit model: a study on fetal tissue regeneration.

In this study we developed a model of in vivo intrauterine partial liver resection in the fetal rabbit to analyze fetal liver regeneration. After intravenous anesthesia, 12 time-dated pregnant, California rabbits underwent a midline laparotomy and minimal hysterotomy at 24-25 days of gestational age. One fetus was exposed from each pregnant doe and the fetal liver was partially resected. Cesarean sections were performed 24, 48 and 72 h and 4 days after surgery. Three fetuses operated at 24 days of gestational age and 3 fetuses operated at 25 days were alive at retrieval. The fetuses and the sampled livers were weighed at retrieval and fetal liver weight showed a well-maintained value in all cases. Fetal livers were processed for the common histologic stains. Lymphocytes, polymorphonuclear leukocytes and phagocytes were counted from sections obtained in areas close to the edge of resection. Inflammatory cells showed a peculiar pattern of infiltration at different stages of repair, with a constantly increased number of phagocytes peaking 48 h after resection. Fetal liver seems to present a specific pattern of repair that differs from both the adult liver and other fetal tissues healing after injury.

Animals↗

PubMedDate not supplied

[Cephalometric evaluation of the nasolabial angle].

Current orthodontic treatment aims not only at achieving a good, stable functional occlusion but, increasingly, at improving the cosmetical appearance of the face and profile. To this end, the Authors believe that proper analysis of the nasolabial angle is an important consideration. A cephalometric evaluation of the soft tissue nasolabial angle and its relationship to craniofacial bony landmarks is described. Statistical data are presented from a preliminary sample of 32 orthodontic patients of whom 15 were habitual oronasal breathers. The absolute value of the nasolabial angle was very similar in the two groups but the orientation of the nasolabial angle relative to cephalometric landmarks showed statistically significant differences.

Adolescent↗

PubMedDate not supplied