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Biomedical subjects

F Magnani

Publications and source records attributed to F Magnani.

12 recordsLinked to original sources
PubMed1987

Phase II double-blind randomized study of lonidamine and radiotherapy in epidermoid carcinoma of the lung.

Patients with non metastatic squamous cell lung cancer were treated with radiotherapy (RT) plus lonidamine (LND) or placebo (PLAC), according to a randomized double-blind study design. Treatment with lonidamine 150 mg t.i.d. (27 patients) or placebo (23 patients) started 3 days before RT, lasted up to 7 months. Partial responses were observed in 14 and 6 patients respectively in the LND + RT and PLAC + RT groups. Statistical analysis of the survival curves showed no significant difference between the LND + RT (median 311 days) and PLAC + RT (median 193 days) groups. Stage III patients survived significantly longer (p less than 0.05) when treated with LND + RT (median 318 days) than with PLAC + RT (median 163 days). No synergistic toxic effects between radiation and LND were noted. To confirm these data a new and larger multicentric study is now in progress.

Aged↗
PubMed1987

[Ectrodactyly].

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Adult↗
PubMed1985

[Pyknodysostosis].

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Abnormalities, Multiple↗
PubMed1985

[Medical docimology in radiology].

The authors report the experience of computerized integrated didactics on trial at the Institute of Radiology of the University of Catania. Students majoring in Medicine undergo a propaedeutic written test, consisting in a number of multiple choice questions, before proceeding to the oral examination in radiology. The procedures preceding the test and those following it are accomplished with the aid of a computer. The authors discuss the docimological motivations, the specifications of the system and the results obtained after a trial period.

Education, Medical, Graduate↗
PubMedDate not supplied

[Nose disease caused by occupational exposure to chromium in the electroplating industry: cytomorphological aspects].

Twenty-six workers were studied (9 chrome-platers exposed to chromium dioxide and 17 workers exposed to metallic chromium dust) in order to investigate the macroscopic and cytological changes of the nasal mucosa due to exposure to water-soluble hexavalent chromium or to metallic chromium dust in the electroplating industry and the role of different valencies in the onset of nasal disease. Experimental and epidemiological data have shown that hexavalent chromium, which has strong oxidative power, induces more noticeable toxic effects on tissues and mucous membranes than other compounds. The correlation between the degree of local toxic effects and the chemical state of chromium was demonstrated in both the macro- and the microscopic investigations and in particular in the cytological examinations: cases of atypia were found only in workers exposed to hexavalent chromium. Evidence of atypia raises the question of whether hexavalent chromium may act as a carcinogenic agent on the rhinosinusal mucosa. For this reason, the introduction of cytological nasal examination in health surveillance programmes for this category of workers acquires considerable importance. Sample collection from the nasal mucosa by brushing is the method of choice since it is simple, non-invasive and gives good diagnostic results.

Adult↗