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Biomedical subjects

F M McCorkle

Publications and source records attributed to F M McCorkle.

29 records · Page 2Linked to original sources
PubMed1977

Acute toxicities of selected herbicides to fingerling channel catfish, Ictalurus punctatus.

A scan of the acute toxicities of eighteen common herbicides to one-year-old channel catfish (Ictalurus punctatus) was conducted. Herbicides causing less than 10% mortality in 48 hr at 10 ppm were: alanap, chloramben, 2,4-D acid, 2,4-D dimethyl amine salt, dalapon, diuron, DSMA, EPTC, fluometuron, metribuzin, monuron, MSMA, nitralin and 2,4,5,-T. The 96-hr LC50 values in pp6 for four nerbicides found toxic were: propanil, 3796; trifluralin, 417; bensulide, 379; and DNBP 118. The toxicity of Dyanap, a mixture of DNBP and alanap, was lower than that of DNBP; there was no apparent synergism between DNBP and alanap in the mixture.

Animals↗
PubMedDate not supplied

Brain monoamine concentrations in turkey poults infected with Bordetella avium.

Six hours post-hatch, large white turkey poults were inoculated intranasally with 5 X 10(7) organisms of the "W" isolate of Bordetella avium. Three hours after inoculation and subsequently on days 7, 10, 14, 21, and 28 postinoculation, 30 infected and 30 uninfected control poults were injected intramuscularly with alpha methylparatyrosine (AMPT, 250 mg/kg), and an additional 30 of each group received a saline vehicle. Three hours after AMPT injection, whole brains from treated and untreated poults from both infected and control groups were removed, weighed, and frozen until assayed for norepinephrine (NE), dopamine (DA), and serotonin (5-HT). B. avium-infected poults had a significant reduction in steady-state NE and Da and a greater depletion of NE and DA after AMPT treatment compared with control poults. Infected poults had significantly reduced whole brain 5-HT concentrations, which persisted through 21 days postinoculation. Altered brain NE, DA, and 5-HT concentrations suggest that the B. avium-infected poults may be less able to cope with additional stressors.

Animals↗
PubMedDate not supplied

Effects of Bordetella avium on lymphoid tissue monoamine concentrations in turkey poults.

Six hours post-hatch, large white turkey poults were inoculated intranasally with 5 x 10(7) cells of the W isolate of Bordetella avium. Three hours after inoculation and subsequently on days 7, 10, 14, 21, and 28 postinoculation, poults from infected and control groups were killed by cervical dislocation. Thymus, spleen, and bursa of Fabricius were removed, weighed, and frozen until assayed for norepinephrine (NE), dopamine (DA), and serotonin (5HT). B. avium infection caused a reduced concentration of NE, DA, and 5HT in the spleen, thymus, and bursa of Fabricius. The reduced concentrations of these monoamines in lymphoid tissues of diseased poults may be a normal response during the course of a disease or during the mounting of an immune response.

Animals↗
PubMedDate not supplied

Alcaligenes faecalis infection in turkeys: effects on serum corticosterone and serum chemistry.

The serum levels of corticosterone, total calcium, inorganic phosphorus, protein, sodium, and potassium were determined for turkey poults from 1 to 42 days of age. Corticosterone levels were higher at days 10, 14, 21, and 28 in Alcaligenes faecalis-infected turkeys than in uninfected poults. The corticosterone responses in this study indicate that A. faecalis infection stimulates adrenal cortical function even in the very young poult, which ordinarily does not show adrenal cortical responsiveness to various environmental and physical stressors. No differences were observed between infected and uninfected turkey poults in other serum chemistries.

Alcaligenes↗
PubMedDate not supplied

Pathogenicity of various isolates of Alcaligenes faecalis for broilers.

Day-old broilers or specific-pathogen-free chickens were inoculated intranasally with approximately 1 X 10(8) organisms of eight different field isolates of Alcaligenes faecalis. Major differences in the pathogenicity of isolates and their ability to colonize the trachea were found. Only two isolates (Wilson and Lockamy) produced mild clinical signs of respiratory disease ("snicking," dyspnea). The same two also colonized the respiratory tract, especially the trachea, in large numbers; they persisted for 31 days. Of the remaining six isolates, five were also able to colonize the respiratory tract but did so to a lesser degree and less persistently, without causing clinical signs. Only one isolate (CS) was incapable of becoming established in the respiratory tract of chicks after intranasal inoculation.

Alcaligenes↗
PubMedDate not supplied

Immediate hypersensitivity (anaphylaxis) response in uninfected and Alcaligenes faecalis-infected turkey poults.

The immediate hypersensitivity (anaphylaxis) response in uninfected and Alcaligenes faecalis-infected turkey poults was studied. The optimum challenge dose of bovine serum albumin (BSA) to elicit an anaphylactic response was 40 mg/kg body weight, and the optimum poult age was 4 to 5 weeks. The response latency time was 7 days. The anaphylactic response was specific for the sensitizing antigen used. No differences were observed between A. faecalis-infected and uninfected poults in the immediate hypersensitivity response to BSA.

Age Factors↗
PubMedDate not supplied

Histamine-sensitizing factor of Alcaligenes faecalis.

Alcaligenes faecalis produced a histamine-sensitizing factor (HSF) in turkey poults and mice, which was detected in poults by an infraorbital sinus test and passive cutaneous anaphylaxis test and in mice by a rectal-temperature differential test. The A. faecalis HSF appeared to be similar to that produced by the genus Bordetella and may be partly responsible for the clinical signs of alcaligenes rhinotracheitis in young poults.

Adjuvants, Immunologic↗