Biomedical subjects
Publications and source records attributed to F M Levy.
The serum levels of IgG, IgA and IgM as well as total proteins were followed from birth to one year of age in a sample of 44 infants. Values for a 'healthy' population are presented. The results of correlation analysis question current views on the independence of the different immunoglobulin classes.
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The evolution of the titers of transmitted IgG and diphtheria antitoxin was studied in 20 neonates during the first 2 months of life (6 serum samples for each). A rapid fall of the passive IgG titer was observed during the first weeks: as a rule the higher the initial titer the greater the fall. After the 15th day the rate of decline slows down. The evolution of the titer of transmitted maternal diphtheria antitoxin depends also on the initial level, and if it is low it can remain more or less constant for a long time. The initial level of passive IgG does not influence the drop in diphtheria antitoxin titre and vice versa. Therefore, the evolution of total IgG and diphtheria antitoxin levels appear not to be interdependent.
The blood titers of IgG, IgA and IgM and total proteins were determined in October 1971 (dry season) and again in April 1972 (wet season) among girls and boys belonging to 4 ethnic groups: White, Bantu, Indian, Mixed. Parasitic studies were also done. These studies indicate a rise of IgM among the girls and of IgA in both sexes from October 1971 to April 1972. The average IgM titer among the four groups is higher than the one found in the Occident. This is especially notable for the Bantu and the Mixed. The Indian levels exceeded, on the average, the White group's. The average IgG figures are only slightly higher than those found in the literature for Western populations. Genetic influences do not appear to explain the differences found between the ethnic groups. The role of environment is stressed, and parasitic influences are discussed.
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Successive evaluations of diphtheritic (AD) and tetanic antitoxin have been made from birth to twelve months in infants receiving at 3, 4 and 5 months an immunization with antidiphtheritic, antitetanic and absorbed antimeasles vaccine. The decrease of AD of maternal origin is not, contrary to common opinion, regularly exponential. Factors influencing the elimination of AD from maternal origin are discussed. An important decrease is often observed after the first immunizing infection. AD level evolution is independent from that to IgG but there is a correspondence at birth in mother and infant between the highest values of AD and the lowest values of total proteides. The commonly observed existence of AD in mother blood indicates the persistence in Maputo of a strong diphteric endemy, and this justifies the association of the antidiphtheritic vaccination to the antitetanic one. After immunization, high levels of antibodies are always reached for tetanic antitoxin and a little less, regularly, for AD. High levels of AD are more frequent in infants having demonstrated no infectious symptoms. Towards the end of the first year, antibodies levels frequently decrease. From these findings possible ways are discussed for immunizing infants in Africa with antitoxins.
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