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Biomedical subjects

F M LaForce

Publications and source records attributed to F M LaForce.

At least 91 records · Page 5Linked to original sources
PubMed1976

Multidrug-resistant Proteus rettgeri: an emerging problem.

The recent development of multidrug-resistant strains of Proteus rettgeri prompted a 6-year review of infections with this organism. Ninety percent of infections involved the urinary tract. Fifty percent of infections occurred on the neurology ward, where a progressive annual increase in attack rate was noted. Statistically significant (P less than 0.005) increases in total length of hospitalization, length of hospitalization before infection, presence and duration of indwelling Foley catheterization, prior exposure to antibiotics, and the prevalence of paraplegia were present in P. rettgeri urinary tract infections as compared with a control group. A progressive increase in resistance to kanamycin, streptomycin, ampicillin, and gentamicin occurred during 6 years. Disc diffusion sensitivities of recent isolates show total resistance to commonly tested antibiotics. Eighty percent or more of strains are inhibited, however, by 3.13 mug/ml of amikacin and cefoxitin, and 0.4 mug/ml of ticarcillin.

Amikacin↗
PubMed1976

Effect of alveolar lining material on phagocytic and bactericidal activity of lung macrophages against Staphylococcus aureau.

Unstimulated rabbits were sacrificed and their lungs washed with heparinized saline. After alveolar macrophages were harvested, the cell-free lavage fluid was centrifuged at 47,000 X g to recover a small, whitish, surface-active pellet (F fraction.) The supernatant was concentrated 15-fold by vacuum dialysis (P fraction). Alveolar macrophages in a serum-free system were challenged with radiolabeled (32P) Staphylococcus aureus preincubated in either balanced salt solution or F or P fraction. A small increase in alveolar macrophage bacterial uptake occurred with P fraction-treated staphylococci. P fraction from locally immunized animals further enhanced phagocytosis. In bactericidial experiments, alveolar macrophages were allowed to phagocytize staphylococci preincubated in either balanced salt solution or F fraction. Intracellular bactericidal activity of alveolar macrophages was quantitated by lysotaphin lysis of extracellular bacteria and quantitation of viable intracellular bacteria. Enhanced lung macrophage bactericidal activity against F fraction-incubated staphylococci was noted.

Aerosols↗
PubMed1975

Air-rinsing after dialysis. A mode of transmission of hepatitis virus.

During a recent outbreak of hepatitis B among patients receiving dialysis, georgraphic and temporal distribution of cases in the absence of exposure to blood products suggested patient-to-patient transmission. The patients who contracted hepatitis used Kiil dialyzers with a single-pass dialysate system, while patients who used hollow-fiber dialyzers appeared to be protected. Blood was returned to patients after Kiil dialysis by the air-rinse technique with the use of a nonsterile plastic tube attached to a manometer bulb. Laboratory experiments demonstrated that Staphylococcus aureus and poliovirus became widely distributed throughout the Kiil dialyzer when introduced during the rinse phase by contaminating the air-rinse tubing.

Air Microbiology↗
PubMed1975

Serologic studies in suspected visceral candidiasis.

Twenty-six healthy controls and 45 patients with clinically suspected candidiasis were studied utilizing precipitin determination by double immunodiffusion, agglutinin titers, and presence of clumping factor by microscopy. The data are used to evaluate the specificity, reproducibility, and ease of performance of the procedures. Our results indicate that there is considerable overlap in agglutinin titers in patients with or without visceral candidiasis and that determination of clumping factor by microscopy only is inadequate for diagnosis. Precipitin tests were positive in 80% of patients with visceral candidiasis (exceptions were highly immunosuppressed hosts). This test is easily performed, reproducible, and can be applied in any general hospital laboratory. Neither agglutinin nor precipitin determination appears to be applicable to determining duration of therapy.

Agglutinins↗
PubMed1971

Clinical and epidemiological observations on an outbreak of plague in Nepal.

In the autumn of 1967, plague broke out among hill people in western Nepal, a country that had not previously reported human plague. Two persons were infected from an active sylvatic focus at a grazing area 5 km from Nawra, the village where the epidemic occurred. The second patient introduced plague into the village where the rest of the cases occurred. Clinical and epidemiological evidence suggests that plague was spread both by the airborne route, resulting in 6 cases of tonsillar plague and 1 case of primary pneumonic plague, as well as by infected fleas, resulting in 17 cases of bubonic plague. Since no evidence of a rodent epizootic was uncovered in the village itself, and because of the distinct clustering of the bubonic cases, human-to-human spread of plague by infected ectoparasite vectors, presumably Pulex irritans, is thought to have occurred.This focus probably represents the most southerly boundary of the central Asian plague area yet identified.

Adolescent↗