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F M Honrubia

Publications and source records attributed to F M Honrubia.

56 records · Page 4Linked to original sources
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Alpha-tocopherol derivatives and wound healing in an experimental model of filtering surgery.

OBJECTIVE: To describe the effect of alpha-tocopherol derivatives (acetate and acid-succinate) on the histopathological characteristics of the surgical fistula in an experimental model of filtering surgery. MATERIALS AND METHODS: Thirty pigmented rabbits were divided into 3 groups. Twenty-four hours before surgery the animals were injected subconjunctivally with 0.5 mL of solution that depended on the group of treatment: Group 1 (n = 10) 0.75% ethanol in balanced salt solution (BSS); Group 2 (n = 10) 100 microg alph-tocopherol-acetate in 0.75% ethanol in BSS; Group 3 (n = 10) 100 microg alpha-tocopheryl-acid-succinate in 0.75% ethanol in BSS. Histological findings were evaluated 30 days after surgery. RESULTS: The groups treated with alpha-tocopherol derivatives showed a higher percentage of persistence of the fistula and better intraocular pressure (IOP) control. CONCLUSIONS: Alpha-tocopherol derivatives showed antiproliferative properties in this experimental model of filtering surgery.

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[Pattern electroretinogram in anterior ischemic optic neuropathy].

INTRODUCTION: Anterior ischemia optic neuropathy is defined as ischemia of the disc optic papilla nerve. The aetiology is multifactorial and causes ischemia of the optic disc and apoptosis of the nerve cells of the retina. OBJECTIVE: To study the retina of patients with anterior ischemia optic neuropathy by means of the electroretinogram pattern (PERG) to assess the function of ganglion cells of the inner layers of the retina. PATIENTS AND METHODS: We studied 12 patients referred from the Ophthalmology Department with the diagnosis of anterior ischemia optic neuropathy. The electrophysiological study consisted of PERG and PEV within 20 days of the episode. The latencies and amplitudes of the different components of the responses and the ratios of the PERG amplitudes were determined. RESULTS: No significant differences were seen in the P50 component of the PERG or the latency of the N95 component. However, statistically significant values were obtained for the amplitude N95. These differences were greater when measured from a nonlinear baseline. CONCLUSIONS: The PERG is useful for early diagnosis of patients with anterior ischaemia optic neuropathy. Measurement of the N95 is more useful when a nonlinear baseline is used. This shows dysfunction of the ganglion cells of the inner retina caused by ischaemia and retrograde degeneration of axons and cell bodies of the optic nerve.

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