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Biomedical subjects

F M Guttman

Publications and source records attributed to F M Guttman.

At least 73 records · Page 4Linked to original sources

Hematoma of bowel and cellulitis of the abdominal wall complicating herniography.

Two complications of herniography are presented: a hematoma of bowel causing intestinal obstruction, and a cellulitis of the abdominal wall causing septicemia. A technical error probably caused the hematoma and gastroenteritis played a role in the cellulitis. We have now narrowed our indications for herniography. We think it should be reserved for more difficult diagnostic problems such as recurrent inguinal hernia, recurrent hydrocele or eventration of the diaphragm.

Abdominal Muscles↗

Renal trauma in children.

In children the kidney is the organ most frequently injured as a result of blunt abdominal trauma. Controversy exists as to the management of injuries of intermediate severity. At the Hôpital Sainte Justine in Montreal, from 1970 to 1976, 71 children aged 2 to 15 years were admitted because of renal trauma caused by blunt abdominal injury. Class I or II lesions (minor injuries) were found in 69% and class III or IV lesions (major or critical injuries) in 31%. Several severe injuries were treated conservatively. There was one death due to multiple associated injuries. Ten patients underwent surgery; nephrectomy was performed in one and heminephrectomy in two patients. One patient with an avulsion injury to the pedicle survived after "bench surgery" and reimplantation of the bruised kidney. Follow-up was obtained in 57 patients; 2 showed posttraumatic scarring. None required subsequent nephrectomy for hypertension or infection.

Adolescent↗

Avulsion injury to the renal pedicle: successful autotransplantation after "bench surgery".

Avulsion injury to the renal pedicle from blunt trauma is a common injury in children. We report a patient who survived this injury with successful reimplantation of the kidney after bench surgery to trim the vessels and the ureter. The function of this kidney is somewhat impaired and shows posttraumatic scarring 19 months post-surgery. This appears to be the first report of such a patient in the literature.

Child↗

Preservation of canine small bowel by freezing.

A total of 133 canine small bowel segments were isolated in 51 dogs according to a previously described technique that permits an in vivo freeze-thaw experiment to be carried out after perfusion with various cryoprotective agents. All control segments (33) survived. One hundred segments were frozen with cold intra-arterial helium and ambient cold nitrogen gas after perfusion with dimethyl sulfoxide (DMSO), inositol, or glycerol in 5% and 10% concentrations, alone, or combined, and with chlorpromazine and hydrocortisone added. Inositol had no cryoprotective effect. Approximately one half of segments frozen after protection with DMSO and with glycerol alone or combined with inositol survived the freeze-thaw injury and were intact on long-term follow-up.

Animals↗

Short term hypothermic perfusion for intestinal preservation with dimethyl sulfoxide.

Morphologic changes, resulting from intracellular or extracellular perfusates with dimethyl sulfoxide as a cryophylactic agent, are similar and probably due to the anoxic period, after short term perfusion. These changes are temporary and are followed by complete recovery. No statistically significant changes in disaccharidase activity between intracellular and extracellular perfusates are found in the jejunal mucosa. No differences are found between normal disaccharidase activity and values obtained experimentally. Results of this study support the suggestion that vascular endothelial damage, as observed in evaluations utilizing the electron microscope, is certainly an important factor in the limitation of perfusion techniques of the intestine.

Animals↗

The pathogenesis of intestinal atresia.

The records of 28 patients with duodenal and 31 with jejunoileal intestinal atresia or stenosis were studied. Vomiting and abdominal distention were the most prominent symptoms; an unusual colon may be present in jejunal as well as ileal obstruction and is not pathognomonic for ileal obstruction. Intestinal atresia is associated with a high incidence of preterm babies but with a low incidence of intrauterine growth retardation. Fifty-three infants were operated upon; the overall survival rate was 79 per cent. The high percentage of mortality in duodenal obstruction is due to associated malformations. Theories of the pathogenesis of intestinal atresia do not seem to fit current clinical and experimental evidence in all patients. Possibly, different factors play a role in separate situations.

Abnormalities, Multiple↗