Biomedical subjects

F M Frattaroli

Publications and source records attributed to F M Frattaroli.

22 records · Page 2Linked to original sources

PubMed1986

Surgical indications and techniques in the treatment of chronic pancreatitis.

Forty-six patients operated on for chronic pancreatitis are reported. 3 (6.4%) underwent splanchnicectomy, 29 (59.2%) Roux-en-Y side-to-side pancreaticojejunostomy, 17 (34.6%) resective procedures (8 left hemipancreatectomy, 5 subtotal pancreatectomy, 3 pancreaticoduodenectomy, 1 total pancreatectomy). Overall postoperative morbidity was 13%: 29.4% after excisional surgery and 3.4% after drainage procedures. One patient treated by subtotal pancreatectomy died because of a hepatorenal syndrome. All the 3 patients treated by splanchnicectomy required resection within two years. The best results were obtained by pancreaticojejunostomy. Drainage procedures represent the operations of choice for chronic pancreatitis as long as correct indications exist. Splanchnicectomy has been discarded as a mean of pain relief because of pain recurrence with time.

Adolescent↗

PubMedDate not supplied

Antioxidant agents and colorectal carcinogenesis: role of beta-carotene, vitamin E and vitamin C.

In consideration of findings reported in the literature and of our study, we examined the correlation between antioxidants (beta-carotene, vitamin C, vitamin E) and colorectal carcinogenesis. Although diagnostic progress has been made in the last decades, no significant improvements in death rates have been achieved in the western world. Exogenous factors might be responsible for a complex alteration process of might be responsible for a complex alteration process of normal colonic mucosa into adenoma and carcinoma. Free radicals and reactive oxygen metabolites, due to increased production or to reduced inactivation, following a decrease in the antioxidant burden in the mucosa, might cause damage to DNA, thereby resulting in genetic alterations. This might represent the cause of the transformation process: normal mucosa --> adenoma --> carcinoma. In a prospective study, we observed a reduction of beta-carotene levels in normal colonic mucosa in patients with polyps and colorectal cancer. We also showed that beta-carotene supplementation raises levels of this micronutrient in the colonic mucosa of these patients. Findings from the literature and our trials show a significant decrease in the antioxidant capacity of colorectal mucosa in patients affected by colorectal cancer, although there is a significant interindividual variability. Such results suggest a possible chemopreventive role of antioxidant agents in colorectal cancer.

Animals↗

PubMedDate not supplied

Prevention of postherniorrhaphy persistent pain: results of a prospective study.

Anterior tension-free and laparoscopic inguinal herniorrhaphies represent one of the most common surgical procedure. Postherniorrhaphy persistent pain due to injures of inguinal regional nerves is rare, difficult to cure, often disabling and involving malpractice litigation. In a prospective study, we evaluated the effectiveness of neurectomy of the iliohypogastric nerve in prevention of postoperative persistent pain after anterior tension free herniorrhaphy. Between 1992-1995, we performed 180 anterior herniorraphies in 151 male patients. Iliohypogastric nerve was removed in all the herniorrhaphies. Polypropylene plug and sutured mesh were employed. Postoperative pain and clinical relevance of hypo-anesthesia and paresthesia were assessed. No patient complained of postoperative persistent pain. Hypo-anesthesia, never considered incapacitating, was present in 1% of patients after 2 years. We consider neurectomy of the iliohypogastric nerve a potentially useful surgical step in preventing postoperative persistent pain after anterior tension-free herniorrhaphy.

Denervation↗

PubMedDate not supplied

Bouveret's syndrome: case report and review of the literature.

Bouveret's syndrome, or gallstone duodenal pyloric obstruction, almost always presents with abdominal pain or vomiting. It occurs more commonly in females (65%), with a median age of 68.6 years. The diagnosis is made by endoscopy (60%), upper gastrointestinal series (45%) or by direct abdominal x-ray (23%). The syndrome is mainly treated by surgery (93%), but recently, it has also been treated by endoscopy or extracorporeal shock wave lithotripsy. The mortality rate has improved from 33%, as was the case before 1968, to 12% in recent years. Herein we report the case of a 79-year-old female with Bouveret's syndrome.

Aged↗