[Use of parlodel in endocrine diseases].
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Biomedical subjects
Publications and source records attributed to F M Egart.
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The anorectic drug teronak (made by "Sandoz") was used in the treatment of 73 obese patients, 34 of whom suffered from diabetes mellitus. The drug is well tolerated and had no side effects. Its positive action on the carbohydrate and lipid metabolism was noted during the treatment. The mean loss of weight after a 12-week treatment constituted 10.1 +/- 0.6 kg.
Idiopathic edema is a little studied syndrome occurring in middle-aged women. Edemas are not associated with cardiac, liver or kidney pathology and are frequently caused by psychic trauma, infection or pregnancy. The disease pathogenesis is stipulated by hyperaldosteronism, antidiuretic hormone excess, estrogen-progesterone unbalance, initial disorder of the central hypothalamic regulation, etc. The treatment is mainly symptomatic; the disease course is non-malignant.
Clinical and experimental studies on cerebral components, emotional-motivation--personality sphere, vegetative nervous system and their relationships were carried out in 31 women suffering from idiopathic edema. Three neurogenic factors (psychological, hypothalamus dysfunction and brain homeostasis disorder) influence the disease pathogenesis. It has been demonstrated that these factors correlate well with endocrine and vegetative disorders being the pathological basis of the disease. It is concluded that the neurogenic factors play a different role in the disease pathogenesis. Severe forms of the disease are characterized by cerebro-endocrine mechanisms of the fluid retention, and mild cases by psychovegetative ones.