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F M Davis

Publications and source records attributed to F M Davis.

98 records · Page 6Linked to original sources
PubMed1975

Establishing a private practice in neurological surgery; preparations, problems and pitfalls.

In summary, the young neurosurgeon entering private practice will find he will have to make many non-medical decisions for which he has had little or no preparation during the course of his lengthy training. Just as one spends time planning a careful curriculum in leading to the specialty of neurological surgery, he must also dedicate many hours to establishing a private practice in that specialty. The time spent in investigating these problems in advance will minimize the frustrations in attaining the goal which we are all striving to achieve-personal satisfaction in the delivery of excellent health care.

Neurosurgery↗
PubMed1975

Diver performance: the effect of cold.

Fifteen divers performed five tasks in water of temperatures 20 degrees C and 5 degrees C, using standard scuba equipment. A significant deterioration of performance occurred under the colder condition in: simple arithmetic 13%; logical reasoning 17%; word recall 37%; word recognition 11%; and manual dexterity 17%. Throughout each dive, rectal and five skin temperatures were monitored. Average fall in rectal temperature was 0.5 degrees C during 20 degrees C dives and 1.1 degrees C during 5 degrees C dives. Average body surface temperature fell by 5 degrees C and 12.5 degrees C respectively. Average heat losses calculated from the data were 95 kcal.m(-2).hr(-1) (20 degrees C dives) and 245 kcal.m(-2).hr(-1) (5 degrees C dives). The impairment in word recognition was significantly correlated with the fall in rectal temperature for the 5 degrees C dives. For other tests, the deterioration did not appear to be correlated with body-temperature changes, but rather, occurred rapidly upon cold water immersion. The significance of these findings is discussed in relation to current understanding of the mechanisms by which cold is thought to influence performance underwater.

Adaptation, Physiological↗
PubMedDate not supplied

Humanized anti-IgE mAb Hu-901 prevents the activation of allergen-specific T cells.

BACKGROUND: As a result of the very efficient capture of allergens by IgE that focuses to CD23 on B cells or FcepsilonRI on dendritic cells, allergen-specific T cells can be activated after exposure to very low levels of allergens. This IgE-mediated allergen presentation is 100- to 1,000-fold more efficient than fluid phase endocytosis. The aim of the present study was to determine whether humanized anti-IgE mAb Hu-901 can prevent the activation of allergen-specific T cells by inhibiting IgE-mediated allergen presentation. METHODS: A house dust mite major allergen Der p 1-specific T cell line was generated from an allergic asthma patient, and a model was set up to show IgE-facilitated allergen presentation via CD23 on EBV-transformed B cells. In addition, experiments were performed by FACS analysis, detecting the presence of IgE-allergen complexes bound to EBV-B cells by polyclonal FITC-labeled anti-IgE antisera. RESULTS: The anti-IgE mAb Hu-901 inhibited proliferation of allergen-specific T cells at low allergen concentrations. Inhibition was dose-dependent. This effect could be explained by Hu-901 inhibition of binding of allergen-IgE complexes to CD23 expressed on EBV-transformed B lymphocytes. CONCLUSIONS: These data clearly indicate that anti-IgE antibodies for the treatment of allergy exert their effect not only by inhibiting mast cell/basophil degranulation, but also by preventing T cell activation, which possibly explains the effect of anti-IgE treatment on late-phase reactions noted in clinical studies.

Allergens↗