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Biomedical subjects

F M Chang

Publications and source records attributed to F M Chang.

At least 73 records · Page 4Linked to original sources
PubMed1988

Umbilical artery flow velocity waveforms in fetuses dying with congenital anomalies.

Absent or reversed diastolic component in umbilical artery (UA) flow velocity waveform was observed in eight fetuses with major malformations. Because of the uncorrectable fetal conditions or the parents' reluctance to terminate the pregnancy, no interventions were undertaken and eventually all eight fetuses died in utero. The interval between the abnormal waveform recording and fetal death was between 1 and 7 days (mean 3.6 days). In two fetuses with abnormal diastolic flow, analysis of umbilical vein blood obtained by ultrasound-guided sampling revealed moderately severe acidosis and hypoxia (pH 7.228 and 7.241, PCO2 47.5 and 46.9 mmHg; PO2 14.6 and 14.7 mmHg, respectively). Our observation suggests that once the diastolic component of UA flow velocity waveforms becomes absent or reversed, the fetus is in a state of hypoxia and acidosis and fetal death is impending. This limited experience may help in formulating clinical management when using UA flow velocity waveforms in the monitoring of high-risk fetuses.

Blood Flow Velocity↗
PubMed1988

Rapid karyotyping in fetuses with abnormal sonogram.

Prenatal karyotyping of fetuses having an abnormal sonogram was undertaken in 27 pregnancies between 17 and 39 weeks, using fetal blood obtained by percutaneous umbilical cord blood sampling under ultrasound guidance. Eight chromosomal abnormalities (29.7%) were detected, including 45, X (2 cases), trisomy 21(1 case), 46, XY,-13,+t(13,13) (1 case), 47, XX,+18(3 cases), 47, XXY (1 case). Nineteen fetuses had a normal karyotype (46,XX:9 cases, 46,XY:10 cases). The fetal karyotype was available within 72 h and fetal management was planned accordingly. We concluded that in fetuses with an abnormal sonogram, rapid karyotyping using fetal blood obtained under ultrasound guidance had important implications in obstetric and neonatal management and would facilitate genetic counselling.

Adult↗
PubMed1988

Umbilical vein blood flow measurement in nonimmune hydrops fetalis.

Twenty-five measurements of fetal umbilical vein blood flow were performed in 22 cases of nonimmune hydrops fetalis using real-time and pulsed Doppler duplex ultrasound. The umbilical vein diameter, blood velocity, and blood flow in fetuses with hemoglobin Bart's hydrops fetalis were usually higher than those in fetuses with hydrops fetalis from other causes. Umbilical vein blood flow measurement appears to be an effective technique for differentiating hemoglobin Bart's from non-Bart's hydrops in this series. This hemodynamic characteristic of umbilical vein blood flow may be helpful in determining the etiology of nonimmune hydrops fetalis.

Adult↗
PubMed1987

Percutaneous ultrasound-guided fetal blood sampling in the management of nonimmune hydrops fetalis.

Nonimmune hydrops fetalis can be caused by fetal chromosomal, hematologic, cardiac, or infectious conditions. A fetal blood sample obtained from percutaneous ultrasound-guided fetal blood sampling can offer vital information about the underlying cause of nonimmune hydrops fetalis, and perinatal management can be planned accordingly. Ten cases of nonimmune hydrops fetalis were investigated with percutaneous ultrasound-guided fetal blood sampling and subsequent fetal blood analysis. Nine were proved to be Bart's hemoglobin hydrops fetalis, with 78.2% to 99% of Bart's hemoglobin in the fetal blood. Terminations of pregnancy were undertaken immediately, resulting in a lowered maternal morbidity rate. Free cord loops or an intra-abdominal portion of the dilated umbilical vein can be used for percutaneous fetal blood sampling in nonimmune hydrops fetalis when the placental cord insertion is difficult to visualize. Percutaneous ultrasound-guided fetal blood sampling and subsequent fetal blood analysis will eventually play a key role in the management of the puzzling nonimmune hydrops fetalis if the safety of ultrasound-guided fetal blood sampling can be verified by further clinical studies.

Adult↗
PubMed1987

The placental transfer and concentration difference in maternal and neonatal serum uric acid at parturition: comparison of normal pregnancies and gestosis.

The maternal uric acid (MUA) and neonatal uric acid (NUA) levels were measured simultaneously at parturition in three groups of pregnancies: group I - 83 cases of normal pregnancies, group II - 7 cases of mild gestosis and group III - 12 cases of severe gestosis, totaling 102 cases. Umbilical venous blood samples were taken in all of the cases. Maternal venous blood samples were obtained from 69 patients in group I, 6 cases in group II, and 12 cases in group III. The correlation coefficients of MUA and NUA values were 0.90, 0.91, and 0.95 (all p less than 0.01) in the three groups, respectively, and 0.93 in total series (p less than 0.0001). The high correlation and minimal concentration difference between MUA and NUA in either normal or gestosis suggested free transfer of uric acid via placenta in both directions. Moreover, not only MUA but also NUA levels were significantly different among normal and gestosis groups, and both MUA and NUA showed higher levels in accordance with the severity of gestosis. Both MUA and NUA had negative correlation with birth weight (BW), one-minute apgar score (AS-1) and five-minute apgar score (AS-5). It implied that the uric acid levels at parturition might provide as a reference index for fetal outcome in pregnancy with gestosis.

Female↗
PubMed1978

Follow-up endoscopic study of gastric mucosal changes secondary to gastric ulcer.

A long-term follow-up gastrocamera photographic study of 481 patients with gastric ulcer was conducted at intervals of 3 weeks to 6 months. It showed that gastric ulcers could remain healed for 2 months to 6 years of observation, yet, recurrence of ulceration occurred in 79% including 18% with multiple occurences. Gastric polyp developed in 8 patients whose initial gastrophotography showed no such lesion in the original study. Furthermore, 7 cancers of the stomach developed at sites away from the initial benign ulcer foci. Six of these cases proved to be mucosal cancer and one was an advanced cancer. In 5 of 7 cases of malignancy, the cancer occurred distal to the initial ulcer foci and anaplastic adenocarcinoma was seen in 3 of these. The others were well differentiated adenocarcinomas. No correlation was found among histopathological type of cancer, depth of malignant invasion, location of the new growth or gastric juice acidity in these 7 cases of malignancy. It is concluded that a thorough and routine gastroscopic examination is indicated for all sorts of gastric disorders whether they are initial or follow-up cases.

Adult↗