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Biomedical subjects

F Lopot

Publications and source records attributed to F Lopot.

At least 37 records · Page 2Linked to original sources
PubMed1991

Is urea kinetic modelling an appropriate tool for guiding ultrashort high-flux dialysis therapy?

High-flux dialysers are frequently used for highly efficient ultrashort treatment schedules. To avoid the risk of inadequately low dialysis dose in this treatment strategy where 'every minute counts', it is often advocated to monitor the treatment quality by means of urea kinetic modelling (UKM). However, careful computational analysis of concentration curves generated by UKM versus more realistic two-pool model curves indicates the risk of substantial overestimation of the protein catabolic rate (PCR). Therefore conventional UKM should not be used to monitor and/or guide treatment schedules with dialyser urea clearance greater than 250 ml/min and dialysis time less than 3 h. Under these conditions, PCR can be overestimated by as much as 20%.

Humans↗
PubMed1989

[Optimizing dialysis treatment in acute renal failure].

The empirical dialysis therapy of acute renal failure should be replaced by modern scientific methods of treatment. The classic indications for hemodialysis are hyperkaliemia, hyperhydratation, acidosis and uremia. While previously a dialysis was indicated in a concentration of blood urea nitrogen of more than 70 mmol/l today a serum level of 30 mmol/l is recommended. By the kinetic urea-modelling an individualized and effective dialysis-guidance is possible. The important data may be determined by a simple computer program in few seconds.

Acute Kidney Injury↗
PubMed1986

Can plasma concentration of middle molecules contribute to assessment of adequate dialysis treatment?

The aim of this study was to confirm or to reject whether plasma concentrations of individual fractions of middle molecular weight substances can become parameters for an adequate dialysis treatment and whether there exists a relation between that and some symptoms and signs in patients on regular dialysis. No changes in clinical condition, plasma concentration of middle molecules, or metabolic state after 5 years of short-time dialysis schedule were established. No difference was found in the plasma concentration of middle molecules after 6 months of continuous ambulatory peritoneal dialysis and in patients undergoing hemodialysis treatment. There was also no difference in glomerular filtration rate, blood urea concentration, dialysis index, and duration of regular dialysis treatment in patients with a middle molecular fraction 2 level lower and higher than 5.5 U/L. Elimination of fractions 2-4 and 6 by a 1-m2 Cuprophan coil dialyzer was similar to the elimination of creatinine. Only patients with acute respiratory infection had a fraction 2 higher than controls. Neither conventional parameters nor plasma concentrations of middle molecules can be indicators of an adequate dialysis. The well-being of patients and their metabolic state are the only criteria.

Adolescent↗
PubMed1984

[Measurement of activated whole blood coagulation as a control parameter for heparin dosage in hemodialysis].

A precise dosage of heparin is necessary especially in acute dialysis, but also in chronic dialysis. This can be checked by measuring the partial thromboplastin time, the thrombin time, the coagulation time according to Lee-White or, recently, by automatic measurement of activated whole-blood coagulation. For the latter only 0.5 ml of whole blood is necessary. In a total of 44 examinations the activated whole-blood coagulation time was shown to be well reproducible. In the 40 patients examined there was considerable variation in the sensitivity to and the elimination rate of heparin, which indicates the necessity of individual heparin dosage. Measuring the activated whole-blood coagulation time proved to be suitable for classifying the patients.

Blood Coagulation Tests↗