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Biomedical subjects

F Lithner

Publications and source records attributed to F Lithner.

At least 19 recordsLinked to original sources
PubMed1992

Male predominance of type 1 (insulin-dependent) diabetes mellitus in young adults: results from a 5-year prospective nationwide study of the 15-34-year age group in Sweden.

The incidence of diabetes mellitus in Sweden in the 15-34 year age group was prospectively studied on a nationwide basis, beginning 1 January 1983. A total of 1,214 male and 720 female cases of newly-diagnosed (excluding gestational) diabetes were reported over a 5-year period. This corresponds to an incidence of 20.5 per 100,000/year in male subjects and 12.7 per 100,000/year in female subjects. Most cases were classified as Type 1 (insulin-dependent) diabetes, with an incidence of 15.9 in males and 8.6 in females. The incidence of Type 1 diabetes decreased gradually with age, while the incidence of Type 2 (non-insulin-dependent) diabetes increased. A male predominance was found in all age groups, with a male-to-female ratio of 1.8:1 for Type 1 diabetes and 1.3:1 for Type 2 diabetes. Maximum blood glucose concentration at diagnosis was significantly higher in males than in females in both Type 1 and Type 2 diabetic subjects. In contrast, the percent desirable weight was significantly higher in females, both in Type 1 and Type 2 diabetic subjects. The difference in diabetes incidence therefore cannot be attributed to any methodological error. The present finding of a marked male predominance after puberty in Type 1 diabetes in an ethnically quite homogeneous population supports the hypothesis that environmental risk factors and life-style are important for the development of the disease.

Adolescent↗
PubMed1992

Sensory thresholds for vibration, perception and pain in diabetic patients aged 15-50 years.

The sensory thresholds for vibration, perception and pain were measured in 375/395 of all diabetic patients aged 15-50 years in Umeå county (population 118,500), 79% of whom had type 1 diabetes mellitus (DM). The results were compared with those from 100 healthy control subjects. Both type 1 and type 2 diabetic patients had significantly elevated sensory thresholds compared to control subjects. In multiple regression analysis, patients with type 1 DM had significant associations between elevated sensory thresholds and age, duration of diabetes, height but not with smoking. Type 2 diabetic patients had a significant association only with height and control subjects with age and height. Thresholds were significantly higher in men than in women with type 1 and type 2 DM and in control subjects but were no longer significant after normalizing for height. Thus, age, duration of DM and tall stature appear to be major risk factors and smoking a minor risk factor for elevation of sensory thresholds both in type 1 and type 2 DM and also in healthy control subjects. Gender differences depend on differences in height.

Adolescent↗
PubMed1992

Risk of developing insulin-dependent diabetes mellitus (IDDM) before 35 years of age: indications of climatological determinants for age at onset.

This study analyses data from two nationwide prospective diabetes registries now covering about 3400 cases from 19 million person-years of follow-up in the age group 0-34 years. The risk of developing insulin-dependent diabetes mellitus (IDDM) per 100,000 individuals before 15 years was 386 (95% confidence intervals (CI): 362-410) for boys and 391 (95% CI: 367-415) for girls and by 35 years 701 (95% CI: 671-731) for men and 562 (95% CI: 534-690) for women. The incidence rate showed a maximum for both boys and girls in early puberty. After pubertal years a sharp increase in the male to female incidence ratio of IDDM was notable. At 10-14 years it was 0.94, at 15-19 years 1.59 and at 20-24 years 2.08. A Cox regression model was used to analyse the effects on age at onset of sex, population density and climatological factors as measured by north-south area of residence and season at onset. The effect of sex was confirmed (P less than 0.001). A significant effect (P = 0.004) of season was shown when the four seasons were classified according to a four stage scale related to mean temperature. When dividing Sweden into 11 regions according to north-south gradient (Latitude 55 degrees, 56 degrees, 57 degrees, ..., 65 degrees) a significant effect (P = 0.038) was also found. However, no effects of population density or living near the coast versus in the interior were found. It is concluded that a large proportion of the young are at risk of developing this chronic disease.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1991

The social consequences of insulin-treated diabetes mellitus in patients 20-50 years of age. An epidemiological case-control study.

In order to investigate the social consequences of diabetes we sent a questionnaire to all diabetic patients aged 20-50 years and 1.125 matched non-diabetic controls living in the county of Västerbotten in Northern Sweden. The response rate was 87% and 72%, respectively. Patients more often lived alone (18 vs 13% p less than 0.05) and had no children (39 vs 31% p less than 0.01). They were more often the only child of their parents (14 vs 8%, p less than 0.01). Thirty-seven percent of the patients and 22% of the controls (p less than 0.001) had been absent from work because of illness more than one month continuously during the last 3 years and had more often than controls prematurely retired from work (8 vs 2% p less than 0.001). Patients more often had hobbies (86 vs 76%, p less than 0.001) and were participating in social activities (52 vs 41%, p less than 0.001), but were less satisfied with their leisure time (71 vs 80%, p less than 0.001). Forty percent of the patients vs 31% of the controls (p less than 0.01) did not visit neighbours. Fifty-one percent of the patients vs 44% of the controls (p less than 0.05) never spent leisure time with their work mates. No significant differences were found in education, socioeconomic class, dwelling or household economy. The study shows that there are social differences between diabetic patients and non-diabetic people even though they are not overwhelming.

Adult↗
PubMed1979

[The diabetic foot].

Explore the source record for details and available documents.

Diabetic Angiopathies↗
PubMed1979

The syndrome of inappropriate secretion of antidiuretic hormone. A case report.

A 72-year-old woman with the syndrome of inappropriate secretion of antidiuretic hormone of unknown cause during more than one year of observation is reported. Plasma vasopressin levels were excessively elevated, even during a water load test. Her serum electrolyte abnormalities and general state were ameliorated after fluid restriction. During treatment with demeclocycline the patient was able to increase fluid without deterioration.

Aged↗
PubMed1979

Local traumatization with heat--cutaneous reactions and early effects on serum zinc concentration in rats with alloxan diabetes of very short duration.

Local heat trauma was induced in rats with alloxan diabetes of 3 days' duration. The cutaneous reaction, water content of the skin and serum zinc concentration were estimated. Petechiae within the area of traumatization were observed more often and were more abundant in the controls than in the diabetic animals. There was no difference between diabetic animals and controls with regard to the increase of water content of traumatized skin or to the water content of non-traumatized skin. There was no difference in serum zinc levels between non-traumatized diabetic animals and controls. After traumatization there was a decrease of serum zinc levels in both animal groups, but to a significantly lower level in the diabetic animals compared to the controls.

Animals↗
PubMed1978

Early cutaneous reactions to local traumatization with heat in alloxan diabetic rats.

The effect of cutaneous traumatization with heat in connection with intravenous injection of Evans blue was studied in short-term alloxan diabetic rats. The effect of traumatization was dependent on the degree of traumatization. There was no difference between diabetic animals and controls. The water content of traumatized and non-traumatized skin was determined. There was no difference between diabetic animals and controls with regard to the increase in water content of traumatized skin. Histological and histochemical studies on the effect of surgical cutaneous traumatization did not reveal any differences between diabetic and non-diabetic animals. The results are compared with earlier observations in alloxan diabetic animals with and without ketosis and in long-term diabetes.

Alkaline Phosphatase↗
PubMed1978

Cutaneous reactions to local traumatization with heat in alloxan diabetic rabbits with and without ketosis.

Short-term alloxan diabetic rabbits with and without ketosis were traumatized with local cutaneous application of heat. The degree of traumatization varied with regard to the temperature and duration used. The lowest degree of traumatization which caused intravenously injected Evans blue to be observed within the area of traumatization was determined. There was no difference between diabetic animals without ketosis and controls. A more pronounced traumatization of animals with ketosis was necessary if Evans blue was to be observed, but there was then a significant difference between these and controls. The traumatized skin areas were also studied histologically. The inflammatory reaction induced was judged as being weaker in animals with ketosis.

Animals↗
PubMed1976

Skin lesions of the legs and feet and skeletal lesions of the feet in familail amyloidosis with polyneuropathy.

Twenty-one patients with familial amyloidosis and polyneuropathy have been examined for the presence of skin lesions, localized to the lower legs and feet. The lesions were classified as atrophic skin lesions, hypertrophic scar-like skin lesions, rubeosis plantarum, spontaneous blisters, necrotic skin lesions, yellow nails, traumatic skin lesions, purpura and abundant pigmented small non-atrophic spots. Skeletal destructions in the feet were also demonstrated. In many respects these lesions are similar to those of long-standing diabetes mellitus. I studied the cutaneous reactions to local thermal trauma with heat and cold to the legs and forearms in 11 patients. Petechiae were observed within the area of traumatization with either heat or cold more often in patients than in controls. Four of the 11 patients developed atrophic circumscribed skin lesions at the site of traumatization.

Adult↗