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Biomedical subjects

F Lin

Publications and source records attributed to F Lin.

At least 235 records · Page 13Linked to original sources
PubMed1983

The primary hamster kidney cell rabies vaccine: adaptation of viral strain, production of vaccine, and pre- and postexposure treatment.

The hamster kidney cell rabies vaccine was investigated as a substitute for classical nervous tissue rabies vaccine. The Beijing strain of fixed rabies virus was adapted to primary hamster kidney cells (PHKCs), and four types of rabies vaccine (plain, adjuvant, concentrated, and concentrated adjuvant vaccines) were developed for human use. The potencies of the vaccines met the requirements of the World Health Organization, and these vaccines elicited rather satisfactory antibody responses in volunteers. The postexposure use of vaccine was evaluated in 301 individuals, 97 of whom had been bitten by proven rabid animals. None of the individuals contracted rabies during the observation period. After several years of field trials with both pre- and postexposure vaccines, the evidence indicates that the PHKC rabies vaccines are effective and safe for human use.

Animals↗
PubMed1982

Studies of a human mesothelioma.

Abdominal fluid from a patient with mesothelioma was cultured in vitro, and a cell line designated JMN was established. This cell line has undergone more than 100 passages. Electron microscopic, karyotypic, and heterotransplantation studies as well as the capability of collagen synthesis by this cell line indicated that it is of malignant mesothelial origin. The cell line has proved very useful for the isolation of human pathogenic viruses.

Abdominal Neoplasms↗
PubMed1982

Computed tomographic mammography using a conventional body scanner.

The technique for computed tomographic (CT) examination of the breasts using a conventional body scanner is described, and experience with 67 patients is reported. In the diagnosis of both malignant and benign breast lesions, the results with a body scanner were equal to those of a dedicated CT/M mammographic unit. Although the CT study of the breast cannot replace conventional mammography in screening or in routine diagnostic workup, the unique capability of demonstrating both anatomic changes and increased iodide concentration in a cancer provides many advantages over conventional mammography. CT mammography appears to have the capability to detect breast cancers that are occult to other methods. Indications for a CT study of the breasts are: (1) clinically suspected breast cancer, especially with a mammographically occult lesion; (2) questionable mammographic findings, including microcalcifications, tumor shape, architectural distortion, and uncertain lesion location; and (3) evaluation of postbiopsy or postlumpectomy breast cancers when a primary irradiation therapy is contemplated. Breast CT also appears to be a valuable diagnostic tool in searching for a second primary breast cancer, follow-up study of postirradiation of breast cancer, followup study for postmastectomy patients, and screening procedure for genetically high-risk patients, especially those with dense breasts.

Adult↗
PubMed1981

Computed tomographic mammography. Diagnosis of mammographically and clinically occult carcinoma of the breast.

If breast cancer can be detected early, while it is still localized and before it can be palpated, the prognosis for cure is excellent. Heretofore, conventional mammography has been the only means available to detect cancer at such an early stage. Two cases of minimal breast carcinoma measuring less than 5 mm in diameter have been detected and correctly diagnosed using computed tomographic mammography (CT/M). Both cases occurred in fatty breasts and were clinically and mammographically occult. These cases demonstrate the value of CT/M in the diagnosis of minimal breast carcinoma that would have been missed otherwise.

Adult↗
PubMed1981

The variable manifestations of extraarticular synovial chondromatosis.

Clinically, patients with extraarticular synovial chondromatosis are seen with a juxtaarticular mass due to metaplasia of synovial cells and subsequent formation of cartilaginous nodules. Three patients are described to illustrate the varied clinical and radiographic features of this disease. One patient had involvement of the knee and wrist while another had involvement of the knee along with presumed intraarticular synovial chondromatosis of the elbow. The third patient had a solitary finger lesion. Routine radiographs in extraarticular synovial chondromatosis demonstrate either solitary or multiple calcified juxtaarticular masses with chondroid matrix. Bone scintigraphy reveals intense radionuclide uptake within the calcified masses. Computed tomography clearly defines the extent of the lesion. Arthrography can evaluate for intraarticular extension.

Adolescent↗
PubMed1980

Computed tomography in detection and diagnosis of breast cancer.

From October 1, 1976 through July 31, 1979, at the University of Kansas Medical Center, CT/M examinations were performed on 1625 patients. Seventy-eight cancers were histologically diagnosed. A CT/M study using our contrast medium enhancement technique yields both static anatomical changes and dynamic measurements of abnormal iodide concentrations in the breast cancers. This unique ability of CT/M provides many advantages as compared with conventional mammography in the diagnosis of breast cancer. The detection rate in 78 cancers by CT/M was 94% and 77% for the mammography. The CT/M appears to be specially superior to the mammography for detecting cancers in dense, premenopausal dysplastic breasts. The CT/M can detect totally unsuspected very small breast cancers that were unable to be identified by conventional mammography or physical examinations. The CT/M scan also seems to be a better test for recognizing precancerous high risk lesions. CT/M evaluation affords definitive diagnostic help in instances where the mammographic and/or physical examinations are inconclusive. Although CT/M will not replace conventional mammography in routine breast examinations, it overcomes the limitation of mammography.

Breast↗
PubMed1978

Treatment of cervical intraepithelial neoplasia with the carbon dioxide laser beam. A preliminary report.

Forty-five patients with histologically proved cervical dysplasia or carcinoma in situ were treated by the carbon dioxide-laser method. The carbon dioxide laser induces cell vaporization by causing intracellular steam combustion stimulated by the emission of a mixture of carbon dioxide, nitrogen, and helium. This method of treatment is easily performed in the outpatient clinic without anesthesia, is inexpensive, and is effective in the treatment of cervical intraepithelial neoplasia. The treatment allows preservation of the transformation zone, thus permitting future colposcopic visualization.

Adult↗
PubMed1978

Preoperative diagnosis of potentially precancerous breast lesions by computed tomography breast scanner: preliminary study.

Eighteen cases of severe atypical epithelial hyperplasia of the breast were detected preoperatively by computed tomography breast scanner (CT/M) with contrast enhancement. The CT number before enhancement ranged from -17 to +31 and increased to 26 to 42 after enhancement (5.2-8.4% increase in attentuation). These data suggest that CT/M can differentiate these potentially precancerous lesions from benign fibrocystic disease.

Adult↗
PubMed1977

Isoantigens A, B, and H in morphologically normal mucosa and in carcinoma of the larynx.

A modified Coombs' mixed cell agglutination reaction was performed on biopsy specimens of 24 patients with squamous cell carcinoma of the larynx. Isoantigens A, B, and H(O) were absent in 15 cases, partially lost in eight, and completely retained in one case. In four cases the initial biopsy specimens were histologically benign yet negative for isoantigens. In subsequent biopsies these showed the presence of carcinoma. The morphologically normal-appearing squamous mucosa adjacent to a carcinoma was found to be devoid of isoantigens in ten cases. The investigation suggested that isoantigenic alteration as detected by mixed cell agglutination reaction was a sensitive sign, since it occurred in squamous mucosa prior to recognizable morphologic change for malignancy. The reaction may represent a functional dedifferentiation in cancerous tissue, analogous to but sometimes preceding morphologic dedifferentiation. The results were comparable to those in previous studies of neoplasms of various other anatomic sites.

ABO Blood-Group System↗
PubMed1975

Acinic cell carcinoma: collective review, including bilateral cases.

Bilateral acinic cell carcinoma of the parotid gland is rare. On the basis of one case and a review of 486 parotid acinic carcinomas, unilateral as well as bilateral, total parotidectomy seems to be the treatment of choice for this low-grade malignant neoplasm that recurs commonly following inadequate excision. If involved by tumor, the facial nerve must be taken. Metastases are more likely to lung and bone than to regional nodes. For this reason, radical neck dissection is not routinely indicated.

Adolescent↗