Biomedical subjects
Publications and source records attributed to F Lima.
Gene frequencies of several red cell and serum gentic markers were determined in the three main racial groups--whites, mulattoes and Negroes--of the Cuban population. The results were used to estimate the relative contribution of Caucasian and Negro genes to the genetic makeup of these three groups and to calculate the frequencies of these genes in the general Cuban population.
The "in vitro" spontaneous magnitude and stability with time of the isometric developed tension (IDT) and frequency of contractions of ampullar longitudinal and ampullar circular as well as isthmic longitudinal and isthmic circular muscle, from human Fallopian tubes, were explored. The effects of polyphloretin-phosphate (PPP), an inhibitor of prostaglandins (PG), upon the IDT and frequency of different tubal segments, were also explored. We looked for PGE, and F2alpha in extracts of ampullar and isthmic tubal segments. The initial IDT and frequency (recorded at 10 minutes following equilibration) as well as the stability with time (explored afterward during 40 minutes) were comparable among all the preparations, with the exception of the isthmic longitudinal muscle, which suffered a progressive decrement of IDT. PPP inhibited significantly the IDT of the isthmic circular muscle but had no effect upon the ampullar circular muscle. Whereas PGF2alpha was frequently detected in extracts from the isthmic region, those from the tubal ampullar region showed the consistent presence of PGE1. The results suggested a possible relationship between isthmic PGF2alpha and its spontaneous motility. Also, the peculiar distribution of PGE1 and PGF2alpha could have some bearing on the regulation of the different functions of isthmic and ampullar regions of human Fallopian tubes.
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OBJECTIVE: To study the maternal and fetal outcome in treated antiphospholipid syndrome (APS) pregnancies. METHODS: Sixty pregnancies in 47 APS patients (11 primary and 36 secondary) were followed in a multidisciplinary clinic. Patients testing antiphospholipid antibody positive and having a history of recurrent miscarriages were treated with low-dose aspirin (75 mg) daily. Patients with APS and a previous history of thrombotic events were treated with subcutaneous unfractionated or low molecular weight heparin and low-dose aspirin (75 mg) daily. RESULTS: The live birth rate increased from 19% of their previous non-treated pregnancies to 70% despite a high incidence of obstetric and fetal complications: pre-eclampsia (18%), prematurity (43%), fetal distress (50%) and intrauterine growth retardation (31%). Two predictors of fetal outcome were observed: the previous obstetric history and the presence of thrombocytopenia. Seven pregnancies (12%) were complicated by thrombotic events during pregnancy or during the puerperium. There were no thrombotic events in those receiving a low molecular weight heparin regimen. CONCLUSION: Close obstetric monitoring by a multidisciplinary team and the use of antithrombotic therapy was effective in reducing the fetal wastage in APS pregnancies despite a high incidence of obstetric and fetal complications.
Male osteoporosis is increasingly recognized as an important public health issue. Possible factors include alcohol and tobacco consume and longer life expectancy. The main causes of male osteoporosis are secondary, as hypogonadism, use of glucorticoids and other drugs. The age-related decline in testosterone may be concomitant of ageing or may contribute to reduced bone formation and bone loss in men. Currently, therapy decisions are based on studies in women and animal models, once there is no trials with definitive results in men. Therefore, the aim of this review is to analyse some features of pathophysiology of bone loss in men, as well as the aetiological factors, clinical characteristics and therapy.