Biomedical subjects

F Li

Publications and source records attributed to F Li.

656 records · Page 37Linked to original sources

PubMedDate not supplied

Techniques for covering soft tissue defects resulting from plantar ulcers in leprosy: Part V. Use of the flap in the inguinal region and latissimus dorsi musculocutaneous flap.

The area of distribution of the superficial circumflex iliac, superficial epigastric and superficial external pudental arteries is large and flaps based on them can meet the requirement of different recipient sites. We have transplanted free flaps based on the superficial epigastric artery for repairing plantar soft tissue defects in six leprosy patients. During the follow-up examination 58 to 118 months later there has been no recurrence of ulceration in any of these cases. The latissimus dorsi muscle, is mainly nourished by the thoracadorsal artery and the latissimus dorsi musculocutaneous flap is a large sized, composite structure with abundant blood provision and strong anti-infectious property. The latissimus dorsi flap can be used as an artery-pedicled island flap or as a free flap besides its use as a muscle graft, because of its constant vascular position, wide outer-diameter of the vessels and long pedicle. It can therefore be utilized for repairing soft tissue defect or replacement of paralyzed muscle. We have used the latissimus dorsi musculocutaneous free flap for repairing large skin and soft tissue defects resulting from plantar ulceration in three leprosy patients. During the follow-up period, one patient who had complete drop-foot and had refused corrective surgery had recurrence of the ulcer in the 12th post-operative month. No ulcers had recurred in the other two cases during the follow-up at 48 and 114 months.

Foot Ulcer↗

PubMedDate not supplied

Transplantation of fibula with vascular pedicle for fusion of ankle in leprotic drop-foot.

Devascularized bone grafts are pieces of dead bone and they simply serve as scaffolds for new bone to grow and fill the gap, taking a long time when they succeed in doing so. In contrast, vascularized grafts being living tissues have short healing time, great vitality and strong infection-resisting capacity. We report here the successful use of vascularized grafts of the lower end of fibula for fusing the ankle in five leprosy patients.

Adult↗

PubMedDate not supplied

The ability of electrical measurements to predict skin moisturization. I. Effects of NaCl and glycerin on short-term measurements.

Non-invasive methods to evaluate skin hydration by measuring electrical properties are widely used in the cosmetic industry. However, there is still some controversy about factors that affect measurement. For example, concerns have often been expressed about the possible confounding effect of salts, either in the formulation or on the skin. Ionized salts on the skin may increase electrical conductivity and may lead to changes in electrical properties that are not related to increased water content. We have performed a systematic study of the effects of salt, i.e., sodium chloride, and glycerin on the electrical properties of skin as measured by the three most commonly used instruments, the Nova DPM 9003, the Corneometer CM 825, and the Skicon 200. Formulations containing salt from 0-3% and glycerin from 0-10% were tested for their effects at one and two hours after a single application. Salt lowered the readings in the absence of glycerin and increased the reading in the presence of glycerin. For all three instruments, there was a linear correlation between the measurement and the glycerin level in the presence or absence of salt.

Administration, Topical↗

PubMedDate not supplied

The ability of electrical measurements to predict skin moisturization. II. Correlation between one-hour measurements and long-term results.

We investigated the ability of short-term (one-hour) electrical measurements with three different commonly used instruments to predict the effects of long-term treatment with glycerin-containing formulations on moderately dry leg skin. We report the moisturizing effects of glycerin on healthy female adult skin in a two-week study as measured by electrical conductance and capacitance, transepidermal water loss (TEWL), and clinical grading of skin dryness. The test formulations contained 1.5% NaCl and levels of glycerin from 0% to 15%. Results obtained with a smaller cohort of ten subjects, one hour after treatment, were predictive of moisturizing efficacy in the two-week period among twenty subjects with dry leg skin. Our results show that single application tests can be predictive of longer-term results with humectant-based moisturizers and that electrical measurements of skin conditions correlate well with skin grades.

Administration, Topical↗

PubMedDate not supplied

The role and effectiveness of adjunctive hyperbaric oxygen therapy in the management of musculoskeletal disorders.

The management of musculoskeletal disorders is an increasing challenge to clinicians. Successful treatment relies on a wide range of multidisciplinary interventions. Adjunctive hyperbaric oxygen (HBO) therapy has been used as an orthopaedic treatment for several decades. Positive outcomes have been reported by many authors for orthopaedic infections, wound healing, delayed union and non-union of fractures, acute traumatic ischemia of the extremities, compromised grafts, and burn injuries. Severe side effects have also been reported with this therapy. To aid in the use of HBO therapy in orthopaedics, we reviewed 43 papers published in the past four decades and summarised the mechanisms, effectiveness, indications and contraindications, side effects, and cost impact of adjunctive hyperbaric oxygen therapy in the management of difficult musculoskeletal disorders. Adjunctive HBO therapy is an effective treatment modality for the management of some severe and refractory musculoskeletal problems. If appropriate candidates are carefully identified, hyperbaric oxygen is a limb- and sometimes life-saving therapy. HBO therapy significantly reduces the length of the patient's hospital stay, amputation rate, and wound care expenses. Thus, it is a cost-effective modality. A clinician must understand the side effects and risks of HBO treatment. Close monitoring throughout the treatment is warranted to minimise the risk to the patients.

Clinical Trials as Topic↗

PubMedDate not supplied

Digital tomosynthesis imaging of the lung.

We report our preliminary results of pulmonary imaging by digital tomosynthesis, and describe some advantages of these digitally processed longitudinal tomographic images. Digital tomosynthesis of the lung was performed in 60 subjects, including 56 patients with a localized lesion or diffuse disseminated lesions, with a fluororadiographic TV unit with linear tomographic capability, in conjunction with an image processing unit. Dual energy subtraction digital tomosynthesis was also available in our system. Multiple longitudinal tomographs of the lung, which were reconstructed from a single set of tomographic image data, facilitated easy evaluation of the morphology of pulmonary abnormalities together with related broncho-vascular structures located in the same longitudinal plane as the lesion, and were immune from any problem caused by inconsistent depth of respiration. The image quality of the reconstructed tomographs was greatly improved by digital image processing to reduce tomographic blur and enhance image clarity. Dual energy subtraction digital tomosynthesis was effective in clearly showing the size, configuration, and distribution of calcification in the lesion. Digital tomosynthesis provided useful information in making the roentgenologic diagnosis of pulmonary lesions.

Adult↗

PubMedDate not supplied

Progressive supranuclear palsy with fronto-temporal atrophy and various tau-positive abnormal structures.

An autopsy case of a 67-year-old man with typical clinical features of progressive supranuclear palsy (PSP) characterized by impairment of vertical ocular pursuit movement, pseudobulbar palsy, nuchal stiffness, parkinsonism, and dementia is described. In addition to typical pathological changes of PSP, the present case showed fronto-temporal cortical atrophy, accompanied with various Gallyas/tau-positive neuronal and glial structures such as neurofibrillary tangles, pretangle neurons, glial coiled bodies, astrocytic plaques and argyrophilic threads in the cerebral cortex and subcortical nuclei, and many senile plaques throughout the whole cerebral cortex. The present report suggests that PSP and corticobasal degeneration share a common background in neuronal and glial pathologies, that pathological changes of PSP and Alzheimer's disease are mixed in the entorhinal cortex, amygdala. Meynert nucleus, and hypothalamus, and that dementia with frontal lobe-like syndrome in PSP is related to the frontal and temporal cortical pathologies, and is cortical dementia as well as subcortical dementia.

Aged↗

PubMedDate not supplied

Mechanism of tumorigenesis of renal carcinomas associated with the constitutional chromosome 3;8 translocation.

PURPOSE: Members of a family carrying a constitutional balanced translocation [t(3;8) (p14;q24)] have a high risk of developing multiple, bilateral clear-cell renal carcinomas. Two genetic mechanisms of carcinogenesis for this malignancy have been proposed: (1) disruption of a gene at the translocation breakpoint and (2) mutation of the von Hippel-Lindau tumor-suppressor gene at 3p25. This study further evaluates the role of the von Hippel-Lindau gene in the etiology and pathogenesis of t(3;8)-associated renal carcinomas. METHODS: Two new t(3;8)-associated renal carcinomas were tested for mutations in the von Hippel-Lindau gene by single-stranded conformational polymorphism analysis followed by direct DNA sequencing, for loss of alleles on chromosomes 3p and 8, and for methylation abnormalities in the first cloned exon of the von Hippel-Lindau gene. RESULTS: A missense mutation in the von Hippel-Lindau gene was found in one of the two t(3;8)-associated renal carcinomas. This mutation would produce a stop codon and a truncated protein. Both tumors showed a loss of alleles on the derivative 8 chromosome. When these results were combined with the results of our previous studies, two of the four t(3;8)-associated renal carcinomas, which were examined for molecular genetic changes, showed different von Hippel-Lindau somatic mutations. All renal tumors from the 3;8 translocation family showed loss of the translocated portion of chromosome 3. CONCLUSIONS: These results support a mechanism of tumorigenesis in the chromosome (3;8) translocation family that involves the loss of both copies of the von Hippel-Lindau gene.

Carcinoma, Renal Cell↗