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Biomedical subjects

F Li

Publications and source records attributed to F Li.

At least 595 records · Page 33Linked to original sources
PubMed1991

Treatment of essential hypertension with auriculoacupressure.

Auriculoacupressure was used in the treatment of 291 cases of essential hypertension, in comparison with 51 similar cases treated with Fufang Jiangya (composite hypotensive) Tablets. Analysis of results showed that the therapeutic effects in the 2 groups were similar, while the rate of marked efficacy in the acupressure group was higher than that of the medication group, and the level of blood lipids also significantly dropped (P less than 0.01); there was only minor improvement in blood rheology. In addition, acupressure manifested biphasic regulatory effects on sinus arrythmia. The curative effect of acupressure on essential vascular hypertension was good.

Acupuncture Points↗
PubMed1990

Induction of F9 cell differentiation by transient exposure to retinoic acid.

The F9 cell is a mouse embryonal teratocarcinoma which can be induced to differentiate into visceral endoderm by treatment with retinoic acid (RA). Treatment with RA in conventional studies was carried out in the constant presence of RA. Here we demonstrate that treatment with RA can be as short as 3 hrs to induce differentiation of F9 cells. Morphology, alpha-fetoprotein gene activity, and temporal patterns of F9 cell differentiation are the same with both short- and long-term treatment with RA.

Animals↗
PubMed1990

Coproporphyrinogen oxidase, protoporphyrinogen oxidase and ferrochelatase activities in iron-overloaded and ethanol-treated rats.

The activities of coproporphyrinogen oxidase, protoporphyrinogen oxidase and ferrochelatase in liver homogenates of iron-overloaded and acutely or chronically ethanol-treated rats were assayed by high performance liquid chromatographic methods. Decreased coproporphyrinogen oxidase activity was found in chronically carbonyliron-fed rats while the activities of protoporphyrinogen oxidase and ferrochelatase remained unchanged. Coproporphyrinogen oxidase and protoporphyrinogen oxidase activities in both chronically and acutely ethanol-treated animals were not significantly different from controls. In chronically ethanol-fed rats normal ferrochelatase activity was found.

Animals↗
PubMed1990

Effects of the plant flavonoid baohuoside-1 on cancer cells in vitro.

The novel plant flavonoid 3,5,7,-trihydroxy-4'-methoxyl-8'-prenylflavone-3-O-alpha-L-rham nopranoxide (designated baohuoside-1) was shown to have cytotoxic and cytostatic effects on 6 cancer cell-lines, by means of microscopy, 51Cr-release and growth inhibition. The IC50 on the cells tested ranged from 2.8 to 7.5 micrograms/ml. At tumouricidal concentrations, inhibition of DNA and RNA synthesis, but not protein synthesis was observed.

Animals↗
PubMed1990

Effect of IgG for intravenous use on Fc receptor-mediated phagocytosis by human monocytes.

Polyspecific IgG given intravenously at high doses (IVIG) is used for immunomodulatory therapy in autoimmune diseases such as idiopathic thrombocytopenic purpura and myasthenia gravis. It is assumed that the clinical effect is brought about in part by a modulation of mononuclear phagocyte function, in particular by an inhibition of Fc receptor (FcR) mediated phagocytosis. In the present study, the effect of IVIG on FcR-mediated phagocytosis by monocytes was analysed in vitro. Since monocytes exposed to minute amounts of surface-bound IgG displayed impaired phagocytosis of IgG-coated erythrocytes (EA), the effect of IVIG was studied with mononuclear cells suspended in teflon bags in medium containing 10% autologous serum and IVIG (2-10 mg/ml). Monocytes pre-exposed to IVIG and then washed, displayed impaired ingestion of EA when compared with control cells cultured in 10% autologous serum only. The decrease in phagocytosis was observed with sheep erythrocytes treated with either rabbit IgG or bovine IgG1 and with anti-D-treated human erythrocytes. This suggests that phagocytosis via both FcR type I (FcRI) and type II (FcRII) was decreased. The impairment of phagocytosis was dependent on the presence of intact IgG and was mediated by IVIG from nulliparous donors and from multigravidae to the same extent, suggesting that alloantibodies contained in IVIG have a minor role in modulating FcR-mediated phagocytosis by monocytes. A flow cytometric analysis using anti-FcRI, FcRII and FcRII monoclonal antibodies showed that IVIG treatment upregulated FcRI expression but did not significantly alter the expression of FcRII and FcRIII.

Animals↗
PubMed1990

In vitro reactions of isopropyl methanesulfonate with DNA and with 2'-deoxyribonucleosides.

Isopropyl methanesulfonate (IPMS), an SN1 alkylating agent, is a direct-acting mutagen in bacteria. We recently reported that s.c. and topical administration of IPMS to mice resulted in the rapid induction of thymic lymphomas. Thymic lymphoma induction was not observed following administration of the SN2 alkylating agents methyl methanesulfonate (MMS) and ethyl methanesulfonate (EMS). We have studied the reactions of IPMS with dAdo, dCyd, dGuo and dThd at pH 6.5 to 7.5 and 37 degrees C for 3 h. IPMS formed the following isopropyl (IP) adducts: 7-IP-Gua (4% yield), O6-IP-Gua (8%), O2-IP-Cyt (1%), O2-IP-dThd (2%), 3-IP-dThd (1%), and O4-IP-dThd (0.4%). Adducts were characterized from UV and mass spectra. IPMS was reacted in vitro with calf thymus DNA (pH 6.5 to 7.5, 37 degrees C, 3 h) and yielded (nmol/mg DNA): 7-IP-Gua (22) O6-IP-dGuo (11), O2-IP-Cyt (9), O2-IP-dThd (2), O4-IP-dThd (2), 3-IP-Ade (0.2) and 3-IP-dThd (0.2). The relatively greater alkylation of exocyclic oxygen atoms in DNA by IPMS compared to values for MMS and EMS reported by others, may play a role in the induction of thymic lymphomas in mice by IPMS and the lack of such activity by MMS and EMS.

Alkylating Agents↗
PubMed1990

[Aging-resistant function of soybean phospholipid paste].

Existing chiefly in biomembrane system, phospholipid is a fundamental component in the tissues of all organisms. The ageing of biomembrane is manifested mainly in the changing of phospholipid composition. Experiments have shown that soybean phospholipid paste is obviously helpful in decreasing blood lipids and retarding the ageing process of tissues, thus making a good natural agent for resisting ageing.

Aged↗
PubMed1989

Coproporphyrinogen oxidase, protoporphyrinogen oxidase and ferrochelatase activities in human liver biopsies with special reference to alcoholic liver disease.

The activities of coproporphyrinogen oxidase, protoporphyrinogen oxidase and ferrochelatase have been assayed in human liver biopsies using recently developed highly sensitive specific enzyme assays. The specific activities (nmol/min/mg protein) in controls were 0.010 +/- 0.003 (mean +/- S.D., n = 11), 0.18 +/- 0.07 (n = 9) and 0.062 +/- 0.022 (n = 8), respectively. The total activities (mumol/min/liver) were determined, using ultrasound to determine liver volumes, and were 2.6 +/- 0.6 (n = 5), 36.6 +/- 13.9 (n = 6) and 14.2 +/- 5.4 (n = 3), respectively. Both specific and total enzyme activities in alcoholics with fatty liver were not significantly different from normal controls. Decreased protoporphyrinogen oxidase activity (0.08 nmol/min/mg protein or 20.2 mumol/min/liver) was found in two patients with variegate porphyria. In a patient with erythrohepatic protoporphyria a reduction of the ferrochelatase activity (0.01 nmol/min/mg protein) was demonstrated.

Biopsy↗
PubMed1989

A database of isoinertial trunk strength tests against three resistance levels in sagittal, frontal, and transverse planes in normal male subjects.

Spatial joint complexes, such as the spine, require multiaxial systems to adequately assess their functional capacity. The B200 Isostation (Isotechnologies, Inc., Carrboro, North Carolina) is a triaxial system that has three hydraulic pumps under control of an IBM-XT. The transducers measure the torque, angular position, and velocity for all axes simultaneously. There is no isoinertial data base available for strength at different resistances in the sagittal, coronal, and transverse planes. A normal data base for dynamic performance against resistances equal to 30%, 50%, and 70% of the maximum isometric strength of trunk muscles in all three planes was established.

Adult↗
PubMed1989

Reproducibility of trunk isoinertial performances in the sagittal, coronal, and transverse planes.

A new triaxial dynamometer to quantify the performance of trunk muscles has been developed, and a study was conducted to determine the best control parameters to use with this triaxial isodynamic mode of testing. Nine male subjects were tested at three resistance levels in the sagittal, coronal, and transverse planes. The purpose was to establish the reproducibility of the performance parameters in each plane at all resistance levels, and to identify those parameters which gave the most reliable information for objective assessment of the low back functional state. Measured torque had the highest reproducibility rate, and the most reliable assessments were obtained at the highest resistance level.

Adult↗