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Biomedical subjects

F Levi

Publications and source records attributed to F Levi.

364 records · Page 21Linked to original sources
PubMedDate not supplied

Synthetic adrenocorticotropin for optimizing murine circadian chronotolerance for adriamycin.

An attempt to pre-set the circadian rhythm in murine chronotolerance for adriamycin (ADR) given i.p. or i.v. with ACTH was performed in three studies. In CDF1 mice standardized in LD12:12, it was demonstrated that 1) the circadian rhythm in murine chronotolerance for ADR exhibits a different timing depending upon whether the intravenous or intraperitoneal route is used for the administration of this anticancer agent; 2) ACTH or saline pretreatment does not enhance optimal circadian-stage-qualified ADR tolerance, whatever its route of injection, with any of the circadian stages and schedules explored; 3) near-optimal tolerance can be achieved by a fixed 'best' interval (among those investigated) between ACTH and ADR, irrespective of circadian stage. Tolerance equivalent to optimal circadian-stage-qualified ADR tolerance results from the administration of ACTH 1-17 (HOE433 = Synchrodyn) 24 hours before ADR injection; 4) and acrophase advance of over 6 hours of the tolerance rhythm results from ACTH 1-17 administration at 6 HALO. The acrophase changes do not directly account for an optimal ADR tolerance at a fixed interval of 24 hours after ACTH 1-17. Thus, ACTH may be considered a potential relative chronizer of murine chronotolerance for ADR.

Adrenocorticotropic Hormone↗
PubMedDate not supplied

[Circadian and circannual rhythms in results of functional tests in endocrinology].

Basic aspects of the temporal organization of endocrine circadian systems are summarized. Emphasis is given to the concept of chronesthesy (rythmic changes in the susceptibility of target biosystems) and that of chronokinetics (rhythmic changes in the metabolic fate of hormones and other agents). These complementary concepts are needed for the understanding of circadian and/or circannual changes in results of a test. The following substances used either for stimulation or suppression tests were investigated: metyrapone, ACTH, corticosteroids (e.g. dexamethasone), TRH, HCG, glucose, insulin. The subject's synchronization, the time (clock hour in the 24 hours scale, month in the yearly scale) appears to be at least as important as conventional factors such as subject's sex, age, nutritional state when performing a test and interpreting the results.

Adaptation, Physiological↗
PubMedDate not supplied

Patterns of mortality from major cancers in Europe.

All ages and truncated (35 to 64 years) mortality rates from all neoplasms and from cancers of the lung, stomach, intestines, and breast for the six calendar quinquennia from 1960-1964 to 1985-1989 were computed from official death certification data and population estimates obtained from the World Health Organization database for total Europe (excluding former Soviet Union) and for three broad European areas: (a) member countries of the European Economic Community for the last period of the study; (b) other Western European countries; and (c) Eastern European countries. In Europe, mortality rates for all neoplasms increased for men and decreased for women. The increase in men can be largely explained by the major tobacco-related lung cancer epidemic throughout Europe. Lung cancer mortality rates rose steeply in Eastern Europe, where the truncated rates reached the highest levels ever observed, and there is no evidence of a leveling off. Stomach cancer mortality decreased in all Europe for both sexes, although rates remained higher in Eastern Europe, while intestinal cancer rates tended to level off around the highest values in various areas of the continent. Breast cancer showed a moderate but steady increase. Overall, the most unfavorable trends were in Eastern Europe, due to major epidemics in tobacco-related neoplasms and in other common cancers related to diet and other lifestyle habits.

Adult↗