Search PubMed⌕ Search

Biomedical subjects

F Lejeune

Publications and source records attributed to F Lejeune.

At least 145 records · Page 8Linked to original sources
PubMed1982

A randomized trial of adjuvant chemotherapy and immunotherapy in cutaneous melanoma.

In a randomized trial of adjuvant chemotherapy, immunotherapy, or immunochemotherapy, 761 evaluable patients with pathological Stage II cutaneous melanoma anywhere on the body or with pathological Stage I melanoma of the trunk (Clark's level 3 to 5) were studied by the World Health Organization International Melanoma Group. Wide local excision and excisional regional lymphadenectomy alone were performed in 185 patients and the results were compared with those of surgery plus chemotherapy with dacarbazine (in 192 patients), surgery plus immunotherapy with bacille Calmette-Guérin vaccine (in 203), and surgery plus chemotherapy combined with immunotherapy (in 181). The rates of disease-free survival and overall survival at 36 months were 30.4 +/- 8.3 per cent (mean +/- S.E.) and 41.6 +/- 10.0 per cent, respectively, after surgical treatment alone; 37.2 +/- 7.9 per cent and 46.5 +/- 8.3 per cent after surgery plus chemotherapy; 34.8 +/- 7.9 per cent and 48.7 +/- 8.7 per cent after surgery plus immunotherapy; and 33.6 +/- 7.9 per cent and 50.0 +/- 8.8 per cent after surgery plus a combination of chemotherapy and immunotherapy. None of the differences between groups was significant, and thus no effect of adjuvant therapy could be demonstrated in this study.

BCG Vaccine↗
PubMed1982

Delayed regional lymph node dissection in stage I melanoma of the skin of the lower extremities.

Results of a prospective randomized clinical trial conducted by the WHO Collaborating Centers for the Evaluation of Methods of Diagnosis and Treatment of Melanoma are reported. Five-hundred-fifty-three Stage I patients whose limbs were affected entered the study; 267 were submitted to wide excision and immediate node dissection and 286 had wide excision and node dissection at the time clinically positive nodes were detected. Survival curves of the two treatment groups could be superimposed. No subsets of patients benefitted from immediate node dissection. The authors conclude that delayed node dissection is as effective as the immediate dissection in Stage I melanoma of the extremities if the patient can be checked every three months. If the quarterly follow-up is not guaranteed, immediate node dissection is advisable, at least for melanomas thicker than 2 mm.

Adolescent↗
PubMed1982

Current status of melanoma chemotherapy and immunotherapy.

In the search for an improved prognosis in malignant melanoma after radical surgery, randomized trials arae being conducted examining the results of immunostimulation (BCG or levamisole) with chemotherapy dimethyl - triazeno - imidazole - carboxamide (DTIC) in stage I melanoma. So far, no significant differences between the groups are evident. In stage III melanoma, a series of new agents are being rapidly screened and some appear promising. A closer look at the basic immunopathologic process during the growth of melanomas is might lead to a more effective control of this malignancy.

Clinical Trials as Topic↗
PubMed1981

[Desmoid tumor - transformation into fibrosarcoma (author's transl)].

Report of a case of aggressive musculo-aponeurotic fibromatosis in a 14-year-old girl with transformation into fibrosarcoma, 10 years later. The tumoral mass initiated its growth in the nuchal region but finally invaded both the cervical and the right retroscapular region. Evidence for muscular, osseous and neurological invasion and destruction was found. The tumor could be controlled neither by surgery, nor by radiotherapy and chemotherapy. This case report is studied in the light of cases reported in the literature.

Adolescent↗
PubMed1980

Stage I melanoma of the limbs. Immediate versus delayed node dissection.

553 patients with stage I malignant melanoma of the limbs entered a prospective randomized clinical trial carried out by the W.H.O. Collaborating Centres for Evaluation of Methods of Diagnosis and Treatment of Melanoma from September 1967 to January 1974. 286 patients were submitted to wide excision of primary and node dissection at the time as appearance of regional lymph node metastases and 267 to wide excision and immediate node dissection. Survival was identical in the 2 groups. Different subsets of patients were evaluated to assess whether some groups of patients may benefit from immediate node dissection. As regards sex, females and a significantly higher survival rate than males (p < 0.05), but results were not improved by immediate node dissection. Maximum diameter and elevation of primary melanoma were significantly related to survival but also in these cases immediate node dissection did not achieve better results. 63 patients had an excisional biopsy of their melanoma within 4 weeks before final treatment. This procedure did not worsen survival and also in this case immediate node dissection did not improve survival. 273 cases were classified according to histologic type: survival of superficial spreading and nodular melanoma was not different at a statistically significant level after the 2 treatment modalities. 325 cases were considered classifiable according to Clark's levels, out of these 165 were submitted to immediate node dissection. Neither level III nor level IV cases showed higher survival rate after immediate node dissection. Maximum tumor thickness according to Breslow was evaluated in 338 cases: 188 were submitted to wide excision and immediate node dissection. In no clusters of thickness did the enlarged surgical procedure achieve better results. The authors conclude that there is good evidence that in stage I melanoma of the extremities delayed dissection.

Adolescent↗
PubMed1980

[Abnormal serum iron carrier in a case of malignant histiocytosis (author's transl)].

A patient with malignant histiocytosis had an iron plasmatic concentration above 600 gamma/100 ml. An abnormal iron-binding protein incompletely saturated is demonstrated in the plasma. This protein has an electrophoretic migration near the alpha 2 globulins and no immunological reactions with antitransferrin and antiferritin antibodies. Its affinity for iron is less and its molecular weight is greater than the one of transferrin. Such a protein has not already been described in the plasma and its presence should be related to the malignant disease.

Alpha-Globulins↗
PubMed1980

Laparoscopy in the diagnosis of liver metastases in 80 cases of malignant melanoma.

80 patients with histologically proven malignant melanoma were submitted to laparoscopy. 44 had advanced disease and 36 were clinically locoregional (23 stage I, 13 stage IIb). Results of a liver scan and liver function tests were available before starting this procedure. In all cases, biopsies were obtained through the laparoscope using a Menghini liver biopsy needle, specimens, being taken under visual control from the macroscopically suspected area. If no lesions was seen, two needle biopsies were taken at random from the anterior and posterior areas of both lobes. The liver was invaded in 11% of the patients with advanced disease, and in 23% of those with stage IIb. All the positve laparscopies occurred with biochemistry and/or liver scan were also abnormal, and biopsies taken at random in normal-looking livers were all negatives. Benign tumors were found in 13% of the cases. Some of these were indistinguishable from metastatic melanoma on the basis of their maroscopic aspect alone.

Biopsy, Needle↗
PubMed1980

[An essential hypereosinophilic syndrome. Cytological, cyto-enzymological and ultrastructural studies (author's transl)].

A new essential hypereosinophilic syndrome has been reported in a 53 years old man who presented an important blood and bone marrow hypereosinophilia of unknown etiology since 5 years. The evolution of the clinical course included neurological accidents (hemiplegia, spasmodic quadriplegia, seizures) congestive heart failure, hepatomegaly, transient renal involvement, pulmonary infiltrates with pleural hemorrhage, episodes of diarrhea and fever with weight loss. The cytological study of the eosinophiles showed the existence of abnormal inclusions which were confirmed by the electron microscope. These and cytoenzymological abnormalities led to discussion of the relationship between the essential hypereosinophilic syndrome and eosinophilic leukemia.

Cardiomegaly↗
PubMed1980

[Autoimmune hemolytic anemia anemia followed by acute granulocytic leukemia (author's transl)].

The authors report a case of acute myeloid leukemia developping 5 years after the onset of an autoimmune hemolytic anemia. The cytological origin of the proliferation is difficult to assess: the presence of prominent membranous complexes and a strong positivity of acid phosphatase reaction favour its megacaryocytic origin. However the cytological evolution pleads for the development of successive clones of monocytic origin, may be modified by the treatment. Are the two diseases successive consequences of preexisting state of immunodepression or was such a state created by the autoimmune anemia?

Aged↗
PubMed1978

[Testing the hemalog D in a hematology department of a general hospital in Paris (author's transl)].

Europe's firs Hemalog D was installed in the Hematology Laboratory of the Franco-Musulman Hospital at Bobigny, just outside Paris, in March 1975. The authors' experience with the apparatus since that date has enabled them to analyze the significance of "alarms", "high peroxidase", "large unstained cells", "remainder" and "low rate" in patients with and without hematologic disorders. On the basis of these results it has been possible to define the fate of the various blood cells in the Hemalog D, the role of the apparatus in the ivestigation of hematologic disorders and the type of "cooperation" between the hematologist and the Hemalog D.

Acute Disease↗
PubMed1978

[Peroxidase deficiency in neutrophils in systemic mastocytosis (author's transl)].

A case associating a systemic mastocytosis and an acquired myeloperoxidase deficiency is reported. The myeloperoxydase deficiency is studied by cytochemical techniques in optical and electron microscopy and confirmed by biochemical measures. An important defect in bactericidal and candidacidal activity is demonstrated in vitro in P.N.M. The authors discuss the links between the two anomalies which might bring one more argument for the common origin of both granulocytes and mastocytes.

Blood Cells↗
PubMed1977

Inefficacy of immediate node dissection in stage 1 melanoma of the limbs.

From September, 1967, to January, 1974, a clinical trial was carried out by the WHO Melanoma Group to evaluate the efficacy of elective lymph-node dissection in the treatment of malignant melanoma of the extremities with clinically uninvolved regional lymph nodes. Treatment was prospectively randomized: 267 patients to excision of primary melanoma and immediate regional-lymph-node dissection and 286 to excision of primary melanoma and regional-lymph-node dissection at the time of appearance of metastases. The statistical analysis showed no difference in survival between the two groups of patients, regardless of how the data were analyzed (according to sex, site of origin, maximum diameter of primary tumor or Clark's level or Breslow's thickness). Elective lymph-node dissection in malignant malanoma of the limbs does not improve the prognosis and is not recommended when patients can be followed at intervals of three months.

Aged↗