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Biomedical subjects

F Leca

Publications and source records attributed to F Leca.

80 records · Page 5Linked to original sources

[2 cases of prosthetic tubes in left pathway obstructions].

Two cases of severe left ventricular outflow tract obstruction were managed surgically by the insertion of prosthetic tube grafts. The first case was a 6 year old child with diffuse hypoplasia of the descending aorta. A prosthetic tube graft, from the aortic arch to the distal limit of the descending aorta, was inserted through a double left thoracotomy. The second child, aged 3 1/2 years, had hypoplasia of the aortic ring. In this case, a prosthetic tube with a prosthetic aortic valve was inserted from the apex of the left ventricle to the abdominal aorta. This is a simple operation for a complex lesion. In both cases, as in other reported series, the post operative clinical and angiographic results one year later, were good. Some technical points are discussed, and the features which, in the case of aortic ring hypoplasia, led to the choice of the above method instead of that proposed by Konno, are explained. The extra cardiac tube, in fact, does not involve the cardiac structures. Its insertion is simple and non-traumatic, and particularly indicated for children.

Angiography↗

[Right pulmonary artery-left atrial fistula. Review of the literature apropos of a case].

This is a rare congenital abnormality with only 17 other reported cases in the world literature. The most frequent sign is cyanosis with peripheral arterial desaturation. Angiography with selective injection in the main pulmonary shows early opacification of the left atrium, so confirming the diagnosis. Occasionally, a catheter can be passed through the fistula. Without surgical treatment there is a danger of systemic arterial embolism and two fatal cases were found in our review of the literature. The fistulous connection is often aneurysmal. It arises either from the right main pulmonary artery or from its branch to the inferior lobe. Associated vascular and pulmonary malformations are not rate. Surgical closure of the fistual is curative with immediate regression of the cyanosis and suppression of possible embolic complications.

Arteriovenous Malformations↗

New data on the pharmacokinetics of adriamycin and its major metabolite, adriamycinol.

Twenty-two days after administration by intravenous bolus, of 50 mg of adriamycin to several patients we found concentrations of adriamycin and adriamycinol of the order of 100 pcg/ml. In theory, however, with a terminal half-life of 30 h, the plasma levels of adriamycin and adriamycinol should be close to 0.1 pcg/ml. Further pharmacokinetic investigation was therefore necessary. We have retained for this study nine male patients, aged between 53 and 69 years who received 25 to 50 mg of adriamycin by slow intravenous injection. The HPLC method permitted the detection of 50 pcg/ml of adriamycin and adriamycinol, with the possibility of monitoring their elimination during 120 h (and in one case during 160 h). The terminal half-lives of elimination estimated in 8 patients were respectively 110 +/- 52 h for adriamycin and 92 h 50 min +/- 43 h for adriamycinol. Surface ratios under adriamycinol curves against calculated adriamycin was 1.10 +/- 0.26. Plasma levels found during the To in certain patients correspond to the end of the drug elimination of the previous treatment. It is difficult with a half-life to 110 h to predict the effects of residual concentrations of adriamycin and adriamycinol.

Aged↗

[Aorto-pulmonary windows. Report of fifteen cases (author's transl)].

Fifteen aorto-pulmonary windows have been operated on patients 1,5 months to 6 years old. 6 were associated with other cardiac malformations (ductus arteriosus, VSD, mitral insufficiency, aortic arch atresia). 5 cases died. 3 had other cardiac malformations associated. 10 have an average follow-up of 5 1/2 years. The authors insist on the severity of the cases with high pulmonary pressure, and advise operation during the first year of life.

Aorta↗