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Biomedical subjects

F Langlais

Publications and source records attributed to F Langlais.

At least 73 records · Page 4Linked to original sources

[Surgical treatment of osteoarthritis of the hip (author's transl)].

Surgery can improve function for one or more decades for patients with osteoarthritis of the hip, even though the operations may not be very invasive. The indications must be made by surgeons in collaboration with rheumatologists. There is no patent recipe, no 'common' intervention which gives a reliable result in all cases. The patient must be studied in all stages of development of his disease: his joint structure in the radiogram, the morphology of the bones, the functional requirements and his general state of health influence the decision regarding the possibility and modality of a surgical intervention. The patient's return to an active life which would not have been possible for him under medicinal treatment supports the importance of surgical treatment.

Adult↗

[Cephalic prostheses in femoral neck fractures: Comparison of immediate complications and late functional results of Moore's prosthesis and sealed prosthesis].

In this study the authors compared the mortality of fractures of the neck of the femur treated by femoral prostheses with early walking compared with trochanteric fractures treated by a nail plate and non-weight bearing activity for 2 to 3 months. The mortality in the two series (about 20 per cent) was the same. The authors then compared two series of fractures of the femoral neck, one treated by Moore's prosthesis without cement and the other by an alternative type of femoral prosthesis with cement. They conclude that the mortality was the same in the two groups but that the cemented prosthesis had better functionnal results. Long-term tolerance of the acetabulum was the same in the two types of prosthesis. Total hip replacement is very rarely indicated in recent fractures of the femoral neck.

Aged↗

Osseous concentrations of gentamicin after implantation of acrylic bone cement in sheep femora.

17 sheep received femoral implantation of 'Cérafix Genta', containing gentamicin 0.6 or 1.2 g per dose either unilaterally (first 3 sheep) or bilaterally (remaining 14 sheep). Highest concentrations in bone were measured after 24 and 48 post-operative hours (respectively 36 and 72 mg/kg for Cérafix 0.6 g and 1.2 g). Gentamicin concentrations in bone marrow and femoral heads were in the same range. Blood and urine concentrations of gentamicin measured in sheep were comparable to those obtained in man. An extrapolation of the gentamicin behaviour from sheep to humans, might be possible: the sheep weight and femoral dimensions were comparable to those of humans and the method of implantation was similar in man and animal. For up to 18 months after operation, gentamicin levels in bone were always higher than critical concentration (4 mg/kg). For the early post-operative period, blood and urine levels always remained below gentamicin toxic concentrations.

Acrylates↗