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Biomedical subjects

F Lange

Publications and source records attributed to F Lange.

At least 73 records · Page 4Linked to original sources
PubMed1983

Pulmonary fibrosis subsequent to high doses of CCNU for chronic myeloid leukemia.

Two patients treated for chronic myeloid leukemia with high doses of CCNU (1100 mg/m2 and 1240 mg/m2, respectively) developed a fatal pulmonary fibrosis. This side effect has never been reported for this nitrosourea but only for BCNU and methyl-CCNU. The responsibility of CCNU in the pathogenesis of pulmonary fibrosis seems very likely. The possibility that the underlying disease or other chemotherapeutic agents may increase the risk of pulmonary toxicity can, however, be discussed. In addition, 13 other adults treated for chronic myeloid leukemia with various doses of CCNU were reviewed. No respiratory symptoms appeared in the ten patients who were given less than 950 mg/m2. Three patients who received more than 1100 mg/m2 developed pulmonary symptoms with the same clinical and radiologic pattern as in the two cases with pathologic documents, and two of them died from acute respiratory failure. Although lung specimens were lacking from these three patients, it is suggested that the pulmonary toxicity of CCNU may be dose-related.

Adult↗
PubMed1983

[Suppurating splenic infarction originating from endocarditis].

Three cases of splenic infarction complicated by abscess formation during bacterial endocarditis are reported. In all three cases there were associated clinical abdominal signs and, in one case, there was persistently positive hemocultures. The diagnosis was made by CAT scanning. The three patients underwent splenectomy and one patient also underwent valve replacement the same day. The methods of early diagnosis of splenic complications during endocarditis and the indications of splenectomy are discussed. Ultrasonography and abdominal CAT scanning are the most sensitive diagnostic methods for splenic lesions. As splenic rupture is associated with a high mortality and this complication may occur at any time during infarction complicated by abscess formation, early splenectomy is justified when abdominal clinical signs are elicited associated with a persistent, infectious syndrome with or without positive blood cultures, under appropriate antibiotic therapy. Splenectomy should also be considered if valve replacement is carried out in the same circumstances to avoid infection of the prosthesis.

Abscess↗
PubMed1983

Fibromuscular dysplasia of the right subclavian artery.

The case of an uncommon form of arterial fibromuscular dysplasia is reported. The anomaly was located in the right subclavian artery. Claudication of the affected limb was the presenting symptom. Angiography was diagnostic in visualizing typical multifocal stenosis of the proximal portion of the right subclavian artery. Complete surgical correction was performed by establishing a carotido-subclavian by-pass graft.

Adult↗
PubMed1983

[Arteriopathies of the lower extremities before 40. Their nature and prognosis].

Sixty-three patients with arteriopathies confirmed by arteriography when they were under 40 years of age were followed up for between 1 and 7 years. The arteriopathy was due to atheroma in 23 cases, to miscellaneous in 22 cases, and to Buerger's disease less frequently (18 cases), suggesting that atheroma should be suspected as being at the origin of an arteriopathy initially in young subjects. Confirmation of the basic nature of the affection is based on several criteria, the most reliable being results of angiography and the detection of associated lesions in other localizations. Histology is a decisive element, but biopsy may involve risks and results are sometimes difficult to interpret. Treatment depends more on clinical symptomatology and the localizations of arterial occlusion than on the nature of the arteriopathy. Sympathectomy is effective in distal lesions, whereas revascularization, adapted to the often small size of the vessels involved and potential impairment in distal vessel circulation, is necessary for proximal lesions. Overall prognosis is more satisfactory in Buerger's disease than in arteriopathy of atheromatous origin, rapid progression occurring in half of the latter cases.

Adult↗
PubMed1982

PEEP-induced airspace overdistension complicating paraquat lung.

This report describes a case of paraquat poisoning, treated with continuous positive airway pressure. After an initial phase of acute respiratory failure with diffuse pulmonary edema, we observed radiologically a complete clearing of both lungs, associated with an aspect of overdistension. Surprisingly, FRC was above normal, as was total quasi static compliance. The patient died on the 15th day, with intractable hypoxemia. Pathologic analysis revealed large zones of parenchyma with overdistended airspaces, explaining the emphysematous-like aspect of the lungs. We propose that the attempts to increase lung volume with CPAP, at an early phase of diffuse epithelial disorganization, may have, partially at least, dilated the remaining distal airspaces.

Adult↗
PubMed1981

[A rare cause of acute respiratory distress syndrome in adults: acute disseminated pulmonary tuberculosis. Four cases (author's transl)].

Four cases of acute respiratory distress syndrome due to miliary tuberculosis are reported. All four patients had tuberculin anergy; three developed disseminated intravascular coagulation. All were treated early with anti-tuberculous drugs. Three patients were intubated and ventilated with positive end expiratory pressure, but they died shortly afterwards. The fourth patient was treated with continuous positive airway pressure and corticosteroids and survived. In view of such reports, the possibility of tuberculosis should be considered systematically in all adult patients with unexplained acute respiratory distress syndrome. The extremely rapid course of the disease and the inconsistent results of standard examinations for tuberculosis justify an "aggressive" diagnostic approach. Extra-pulmonary biopsies, notably of the bone marrow, are very helpful.

Acute Disease↗
PubMed1981

[ACTH measurement in the hypophysis after adrenalectomy and adrenal cortex hormone therapy by means of microphotometry and radioimmunoassay method (author's transl)].

In experiments after adrenalectomy and adrenal cortex hormone therapy the quantity of ACTH was ascertained in the hypophysis of cats by methods of microphotometry and radioimmunoassay. The deviation of increased or decreased amounts was studied in acute as well as in chronic physiological conditions of the cats. The different methods to measure the quantities are equally identifying the physiological conditions.

Adrenal Cortex Hormones↗
PubMed1980

A review of surgical procedures for hallux valgus.

One hundred seventy-two patients who underwent surgical correction of hallux valgus deformity were evaluated. The procedures chosen were: first metatarsal osteotomy in 96, Keller procedure in 42, metatarsophalangeal arthrodesis in 25, and simple bunionectomy in 9. This study allowed the establishment of the following guidelines for surgery. 1) Osteotomy alone yields a satisfactory result in patients under the age of 50 years who have minimal osteoarthritis of the metatarsophalangeal joint. 2) The Keller procedure is suggested in patients over the age of 50 who have significant osteoarthritis. 3) Metatarsophalangeal fusion is suggested in patients under the age of 50 with significant osteoarthritis. 4) Simple bunionectomy revealed poor results in the majority of patients. It should be reserved for the elderly patient with an infected bunion.

Aged↗
PubMed1980

[Morphological identification of pituitary hormones by the aid of pH-determination using microphotometry (author's transl)].

The identification of pituitary ACTH and TSH producing cells was performed by histological staining at the isoelectric points (pH levels: 4.6 and 5.2 respectively) of these hormones in cat. Intensity of stained material in the hormone producing cells was determined by microphotometric technique. By the application of hormones influencing the pituitary ACTH and TSH producing relevant changes in pituitary cells could be detected.

Adrenalectomy↗
PubMed1980

[Morphological classification of surgical forms of bullous emphysema in adult. Role of electron microscopy (author's transl)].

The definition and the classification of bullae are recalled and documented by some examples. Two types of bullae are opposed : bulla found in normal parenchyma and bulla associated with widespread emphysematous lesions. The biochemical and biological mechanisms of the emphysematous changes are briefly described, with a distinction of two different pathogenesis : on one hand, an inherited defect in connective tissue synthesis as in Marfan syndrome, and on the other hand, an unbalance between proteases and antiproteases. The pathologist's contribution to the classification of the surgical forms of emphysema is documented by an electron microscopic study of lung biopsy in some cases : two cases with bullae (a Marfan syndrome and an alpha 1 AT deficiency of the Pi Z phenotype) with diffuse panlobular emphysema; and 4 cases of bullae without radiological evidence of emphysema. The elastic fibres were modified only in the 2 first cases but were normal in the others. A follow up of such cases is needed.

Humans↗
PubMed1980

[Effect of homologous n-alkanoic acids on the function of isolated skeletal muscles. V. Relations between twitch, tetanus and contracture].

Twitch, tetanus, and contractures induced by potassium ions (K+) or caffeine were investigated on isolated bundles of frog muscles. Using supramaximal stimuli the twitch amplitude amounts to about 50% of the tetanic tension (22 degrees C). Usually the contracture in 190 mM K+ is smaller than the tetanic tension, in 20 mM caffeine the contracture maximum corresponds to the tetanus amplitude. All of the mechanical answers are diminished if the fibres were bathed in solutions containing 2.5 to 10 mM Na-octanoate or 0.5 mM decanoic acid. Twitch and tetanic tensions decrease nearly in the same degree. A sequence of tetanic stimulations in a distance of 2 s induces a depression of the amplitudes. Fatty acids increase this depression and delay restoration between the series. Contractures in 190 mM K+ are diminished by a preceding bath in 10 mM Na-octanoate. Contractures with submaximum concentrations of K+ were decreased by lower concentrations of octanoate. The caffeine induced contractures are delayed by fatty acids, but the maximum tension is not reduced. It is supposed that the mobilisation of calcium ions is alterated by fatty acids. The decreasing effect of fatty acids on the mechanical activity, induced by different ways of the muscles' stimulation suggests that the main action may take place in the process of mechanical coupling, probably during the activation of calcium ions.

Animals↗