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Biomedical subjects

F Lancastre

Publications and source records attributed to F Lancastre.

At least 55 records · Page 3Linked to original sources

[Resistance to desiccation of Biomphalaria glabrata adults infested by various miracidia of Schistosoma mansoni].

1200 adult Biomphalaria glabrata were submitted during 6 weeks to anhydrobiosis condition. Some snails were healthy, some were previously infected 3 days or 12 days ago with 8 +/- 2 miracidia of Schistosoma mansoni, others were shedding cercariae. The snails were put on soil or buried into hermetically closed, or ventilated, plastic boxes. There was no survival of snails kept in sealed boxes, or among positive snails, but 44% of control healthy snails and 40.6% of infected (for 3 or 12 days) snails in ventilated boxes were living at the term of the desiccation stage. Survival was better for "on soil" snails than for "buried" snails, but no difference was shown between 3-days and 12-days infection. The surviving desiccated B. glabrata had a lesser death rate and a lesser cercarial production than infected snails kept in water. An inferior production of male cercariae comparatively to female and to "mixed" cercariae was demonstrated by statistical analysis of the cercarial sheddings. In all positive snails, periodic variations of cercarial production was shown, whatever the sex of those cercariae. In addition many pauses of the sheddings were established by the authors.

Animals↗

[Experimental Schistosomiases. I. Study of S. mansoni fecondity as regards to its adaptation to different Biomphalaria glabrata strains (author's transl)].

We compared the infestation of different strains of B. glabrata from Brasil (Recife). Guadeloupe, Martinique and Porto-Rico with 6 to 8 miracidia of S. mansoni (from Recife. We noted the four following points: 1. The planorbid snails from Martinique and Guadeloupe had a low resistance to infestation. 2. The guadeloupean snails showed the lesser rate of positivity and the lower medium amount of emitted cercaries but, in the four strains of snails, the level of the issued cercaries is quite the same. 3. many planorbid snails in the groups studied during more than 2 months, showed significant periodic variations in the emission of cercaries, We thought that those variations might be caused by the alternate maturations of sporocysts born from the same miracidium or from different miracidia. 4. Infestation by S. mansoni had a strong effect on fecondity of the snails but the laid eggs had a normal development.

Adaptation, Physiological↗

[Pulmonary bilharziasis caused by Schistosoma mansoni with impairment of general state].

The authors report on one case of pulmonary bilharziosis at Schistosoma mansoni observed in a West-Indian female showing an impairing of her general condition with fever and dyspnea. Diagnosis was brought out by a pulmonary biopsy, after thoracotomy. Treatment by praziquantel was remarkably efficient. Scarcity of symptomatic cases and paucity of pulmonary radiological pictures are opposite of the frequency of pathological lesions in this parenchyma. The authors discuss the physiopathology of pulmonary bilharziosis in both their invading phase and state phase, as well as their frequency. They come to the conclusion that both parasitological examination of stools and biopsy of mucous membrane of rectum are simple, reliable and harmless implements of diagnosis.

Biopsy↗

[Diagnostic value of parasitologic examinations and of indirect immunofluorescence test in S. haematobium schistosomiasis (author's transl)].

A study has been carried out in 690 patients admitted in a Paris hospital and from Mali, Senegal and Mauretania origin, in order to compare the three available techniques for the diagnosis of infection with S. haematobium: urine centrifugation deposit control, biopsy of rectal mucosa and indirect immunofluorescence test. The prognostic value of each of these three techniques has been reevaluated. (Formula: see text), Living eggs have been detected in 55 p. 100 of the patients by direct examinations and a prevalence of 75 p. 100 has been computaned for S. haematobium.

Fluorescent Antibody Technique↗

[Oltipraz as brief treatment of schistosomiasis (comparison with niridazole) (author's transl)].

161 patients affected by schistosomiasis due in most cases to S. haematobium, and less frequently to S. mansoni, received one day treatment with 4,5 g a day of oltipraz in a first group and, later on, 3 g a day in another group. A control after one year was possible for patients having received 4,5 g one day dosis. Urin control, rectal mucosa biopsy (R.M.B.) and indirect immunofluorescence test (I.I.F.) were performed in patients who did not return to infested areas during that period of time; in almost all cases, the urin control was negative; in 52 p. 100 of the cases the R.M.B. shown no live egg and I.I.F. test was significantly decreased with individual variations. -- These results are compared to those of a previous and similar study on the effects of niridazole. -- Side-effects, mostly digestive or nervous, are frequent with a 4,5 g dose and less frequent with 3 g. They rarely compel to discard the treatment and they never persist after the morning following the treatment is stopped. There is no electrocardiographic change. -- Doses below 3 g in one-day intake are presently studied in order to fix the minimal acting dosis.

Adolescent↗

[Comparative value of parasitological and immunological investigations in the diagnosis of chronic schistosomiasis].

Two group of patients including 63 urinary schistosomiasis and 49 intestinal schistosomiasis were studied with the following investigations: microscopic examination of stools and urines, rectal mucosae biopsy, total IgE dosages, plasmatic proteins values and indirect immunofluorescence. The data obtained led to the following conclusions: --Recovery must be based on the microscopic observation of stools and/or urines and R. M. B. --I. F. I. and IgE dosages alone were not sufficient. --Protides evaluations (IgA, IgG, IgM, orosomucoid, haptoglobin) did not show any informative values and did not seem to be linked with the parasitologic disease.

Chronic Disease↗

[Comparative value of parasitological investigations and immunological reactions in the post-therapeutic surveillance of chronic urinary schistosomiasis].

A comparative evaluation of parasitological (in urine and R. M. B.) and immunological (IgE and I. F. I.) investigations in the post-therapeutical course of the urinary schistosomiasis was carried out in a group of 25 patients treated with niridazole and on a group of 25 patients treated with 35 972 RP. The recovery must be based on both the disparition of eggs simultaneously in urine and R. M. B., the former is not sufficient because eggs could be found in R. M. B. when absent in urine. IgE and I. F. I. reaction gave conflictual data in the evaluation of the treatment.

Humans↗

[Experimental schistosomiasis. II. Infection of Biophalaria glabrata by 2 miracidia of Schistosoma mansoni].

The authors have infected 127 B. glabrata by 2 miracidia of S. mansoni, either on the Same day, or introducing a second miracidium after 3, 7 and 16 days. 1 All the groups of planorbid snails had a low percentage of positivity (31 to 41 %). 2 The first cercarial emissions, in the 4 groups were scattered in the time, the delay being in correlation with the second infection. 3 In the snails reinfected after 3 and 7 days occured the highest emissions, those with the simultaneous double infection or second infection delayed to 16 days, had the lesser emissions. 4 An interval cycle of about 3 weeks was discovered for the highest emissions. All those phenomena are probably due to competition between the sporocysts born from both miracidia. Moreover, evident reduction of the fecundity in the positive snails were shown only after the beginning of the cercarial emissions, while a normal, or even increased fecundity was established in the prepatent period of the infected snails.

Animals↗