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Biomedical subjects

F Lampert

Publications and source records attributed to F Lampert.

At least 181 records · Page 10Linked to original sources
PubMed1979

[Non-Hodgkin's lymphoma in children: improved prognosis through aggressive multiple drug combination and irradiation (author's transl)].

From 1964-1975 43 children with non-Hodgkin's lymphoma (NHL) were treated. 60% of the patients had far advanced disease at diagnosis. Therapy before 1970 consisted of low dose irradiation to the primary and single agent chemotherapy; no C.N.S. irradiation to prevent meningeal recurrence was given. Median survival in this group was 5 months; all patients died. Since 1970 all children with NHL were entered into a modified leukaemia protocol regardless of stage or primary site. Therapy comprised an aggressive multiple drug combination, high dose local irradiation and prophylactic C.N.S. irradiation with intrathecal methotrexate. 41% of the patients treated since 1970 survive in continuous complete remission with a median observation time of 31+ (1-93+) months. All relapses occurred within 30 months after diagnosis. Stage of disease was the most important prognostic factor in our patients. Risk of a primary C.N.S. relapse in the total group was 30% for patients without prophylactic C.N.S. therapy compared to only 6% for patients with treatment.

Adolescent↗
PubMed1978

Combination chemotherapy and radiotherapy for Hodgkin's disease in children.

31 children with Hodgkin's disease were treated at the Children's Hospital, University of Munich, between 1963-1976. Before 1971 the diagnosis of abdominal involvement was based solely on physical findings and radiological studies. Treatment consisted of involved-field radiation; chemotherapy was added in selected cases. Of 15 children treated between 1963-1971, 5 are still in their first remission and 2 in their second remission. Since 1971 exploratory laparotomy and splenectomy have been performed. Radiation therapy was changed from involved- to extended-field therapy and combination chemotherapy was added in all the children. No patient from this group of 16 children relapsed during a median observation time of 24 months (range 12-55 months). The toxicity of the combined treatment does not seem to be prohibitive.

Adolescent↗
PubMed1978

[Juvenile rhabdomyosarcoma. Diagnosis and new therapeutic possibilities].

Seventeen children with rhabdomyosarcoma stage I to III diagnosed since 1973 are presented. The coordinated management utilizing surgical excision, irradiation (5000 rad) and systemic adjuvant multiagent chemotherapy is described. The favorable sites were head and neck sites and genitourinary region. The mean survival is at present 19 months. 14 children are alive and well. 13 children had no tumor recidivation, 1 child had 8 months after beginning of the therapy lung metastases which after irradiation with 2000 rad disappeared. 3 children (stage III) died 9, 14 and 20 months after diagnosis during therapy by metastases. Acute and late effects on normal tissues from radiation and chemotherapy were noted in 12 cases. A review of the literature and therapeutic alternatives in the future are indicated.

Child↗
PubMed1978

[Cell culture of human gingival epithelium].

Gingival explants were taken from 8 volunteers in order to find a method to grow gingival epithelial cells. We succeeded in what we regarded as optimal conditions in achieving a monolayer cell thickness in the culture by means of BHK medium and foetal calf serum.

Cells, Cultured↗
PubMed1978

[Comparative clinical studies on 2 toothbrushing methods--Roll and Bass technic].

The effectiveness of two tooth cleaning methods (Roll and Bass technique) was evaluated in 28 patients. Answers to the following questions were sought: 1. Which of the two methods results in greater reduction of plaque formation? 2. Are difficulties encountered in the learning and practice of each method? 3. Which method gives better results in the less accessible parts of the jaws? A significant difference in the cleaning effectiveness of the two methods could not be demonstrated.

Adult↗
PubMed1978

[Results of Memphis-study VII ("Pinkel-Therapy") in 659 children with acute lymphoblastic leukemia. Cooperative therapeutic study of the German working group on childhood leukemia with participation of 42 hospitals].

659 children with acute lymphoblastic leukemia from 42 German hospitals were diagnosed from January 1, 1971 until December 31, 1974, treated according to Memphis study VII or VIII2, and observed until December 31, 1976. At diagnosis 16,1% of the patients had a leukocyte count over 50 000/mm3, 8,5% a mediastinal enlargement, 2,0% a CNS-leukemia and 1,8% a Down-syndrome. After a treatment time of 2 1/2 years and an observation time of maximal 6, minimal 2 years 329 children (= 50,0%) were living, 257 (= 39,1%) in continuous complete remission, most of these 1-3 years after cessation of therapy. A primary relapse in the bone marrow occured in 36,3%, in the CNS in 10,0% of the patients. A cranial irradiation dose of 1800 rad in 120 patients yielded a CNS-relapse rate of 7,5%. 49 of the 659 children (= 7,4%) died in continuous complete remission, the main causes being interstitial pneumonia and varicella. No difference in initial features and treatment results was found between 7 centres with many patients and 35 hospitals with fewer patients.

Age Factors↗
PubMed1978

Improvements of the electrophoretic mobility test to measure lymphocyte sensitization.

The Electrophoretic Mobility (EM)-test was performed in 316 children to examine their lymphocyte sensitization to a common antigen by measuring the mobility of special indicator cells. The results indicate that this test can serve as an additional help in differential diagnosis of malignant and non-malignant diseases. Measurements in the cytopherometer were facilitated by introducing several technical modifications: 1) The original method of timing with a stopwatch was replaced by two electric watches electrically combined with the cytopherometer. Thus individual faults were reduced. The next improvement of timing at the cytopherometer consisted in the construction of an electronic controller and stopwatch in combination with a minicomputer, data print out, and tape recorder in order to get more reliable results. 2) Further automatic recording of the data is time-sparing and useful for correct evaluation of the EM-test. That can be done now directly on-line in a calculator with a program developed in our laboratory. 3) By using a television monitor for the observation of the indicator particles an additional simplification is possible.

Antigens↗
PubMed1977

Electrophoretic mobility (EM)-test for childhood cancer diagnosis.

Lymphocyte sensitization to myelin basic protein (encephalitogenic factor, EF) was determined in 193 children by measuring the electrophoretic mobility of indicator particles which had been incubated with the supernatant of the lymphocyte-antigen (EF) mixture. A significant decrease in electrophoretic migration time was found in 77 of 85 children with malignant tumours localized in brain, abdomen and extremities, in 36 of 38 children with acute lymphoblastic leukaemia (all except one in hematological remission), and in all 17 patients with lymphoma, in contrast to only 1 of 10 healthy children and 14 of 48 patients with non-malignant disorders. 10 of these 14 "false positive" patients, however, had auto-immune diseases. Thus, with false negative and false positive rates of less than 10%, this test could be of diagnostic help in patients with suspected malignant or auto-immune disease. Two examples of preoperative application of the EM-test are demonstrated.

Abdominal Neoplasms↗
PubMed1977

[Combination chemotherapy and cranial irradiation in 530 children with acute lymphoblastic leukaemia (author's transl)].

530 children with acute lymphoblastic leukaemia were diagnosed between 1. 1. 1971 and 31. 12. 1974, and treated at 35 German hospitals according to the Memphis study VII or VIII2 and subsequently followed until 31. 12. 1976. At diagnosis 17.2% of the patients had a WBC count of over 50,000/mm3, 8.9% had mediastinal enlargement, 2.1% CNS leukaemia and 1.7% Down's syndrome. After being treated for two and a half years and being observed for a maximum of six years (minimum two years) 262 children (49.4%) were living, 203 (38.8%) in continued complete remission, most of them one to three years after end of treatment. Primary bone marrow relapse occurred in 39.6%, but CNS relapse in only 8.7%. Cranial irradiation at a dose of 1800 rad in 70 patients produced a CNS relapse of only 7.1%. Forty-one of these 530 children (7.7%) died in continued complete remission, the main causes being interstitial pneumonia and varicella. There was no difference in initial features and treatment results between six centres which had many and 29 with rather fewer patients. The five-years-survival rate (life-table method) was 41 +/- 3.5% for all 530 children and 10 +/- 3.7% for the 92 children with initial leucocyte counts of over 50.000/mm3.

Chickenpox↗
PubMed1977

[Gingival grafts as therapeutic measures for periodontal diseases (author's transl)].

Gingival grafts represent an operative intervention within the sphere of periodontal surgery which enable a widening of fixed gingiva. Carried out as an outpatient operation, it troubles the patient little. Supported by the oral hygiene of the patient, it creates the necessary conditions for the progression of the periodontal disease to be stopped by local therapy in the region of the gingival pocket.

Gingiva↗
PubMed1977

Lymphocyte sensitization in childhood solid tumours and lymphoblastic leukaemia, measured by electrophoretic mobility test.

A modified electrophoretic mobility (EM) test was performed in 150 children to examine their lymphocyte sensitization to myelin basic protein (encephalitogenic factor). Measurements in the cytopherometer were facilitated by using devitalized sheep erythrocytes as indicator particles instead of macrophages. A significant decrease in EM was found in 29/30 children with acute lymphoblastic leukaemia and in 67/75 children with solid tumours, thus giving a false negative rate in malignant disease of 9/105=8-6%, as compared to 6 false positives among 45 children with non-malignant disorders; 5 of the later "false/positive" 6 patients had autoimmune disease. Results of the EM test in the children with leukaemia were compared with those in 9 patients with non-Hodgkin's lymphoma and 2 with Hodgkin's disease at different stages, but no striking change was seen between different diseases, or after cessation of long-term immunosuppressive chemotherapy. Percentage of "slowing" ranged from 4 to 30%. These results indicate that patients with lymphoid malignancies still have lymphocytes which had been sensitized by a common antigen of the malignant cell clone at the beginning of the disease. The EM test, furthermore, could serve as an additional diagnostic aid in differentiating benign from malignant masses in the abdomen, extremities or intracranial disease.

Abdominal Neoplasms↗
PubMed1977

[The effect of various orthodontic treatment technics on the gingiva].

Out of a group of 30 patients aged from 11 to 15 years, 10 each were treated with either fixed appliances, or removal plates, or by functional orthodontics. Prior to the beginning of the treatment, and one week and six weeks thereafter, pocket depth, SB index, sulcus fluid flow rate, and OH index were recorded. The inflammatory symptoms of the gingiva were shown to be a function of the OH index. Moreover, the OH index grew worse during orthodontic treatment, especially in the group with fixed appliances.

Adolescent↗