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Biomedical subjects

F Lagoutte

Publications and source records attributed to F Lagoutte.

At least 55 records · Page 3Linked to original sources
PubMed1986

[Ophthalmologic manifestations of leukocytoclastic vasculitis. Apropos of 3 case reports].

Ophthalmological lesions enter in the definition of Cogan's syndrome, associated with vestibulo-auditory symptoms. They are present in almost one half of patients with Wegener's granulomatosis and in 10 to 20 p. 100 of patients with periarteritis nodosa, where they may be the initial symptom. Yet they are seldom described in leucocytoclastic angiitis of small vessels, 3 cases of which are reported here. The first case concerns a 71-year old woman with cutaneous leucocytoclastic angiitis which regressed within a few days under dapsone. However, the drug had to be withdrawn on account of acute haemolysis. Thereafter, new skin lesions and severe pain in the left eye with fall in visual acuity developed simultaneously. Eye examination showed a large, marginal ulceration of the cornea extending to the adjacent sclera and reflecting deep involvement of the sclerocorneal limbus. Systemic corticosteroid therapy in doses of 1 mg/kg/day was instituted, resulting in gradual disappearance of the skin lesions and stabilization of the ophthalmic lesion. There remains, however, thinning of the cornea and sclera which entails a definite risk of perforation should the angiitis recur. The second patient was a 54-year old man seen for fever, polyarthralgia, purpura of the lower limbs and rapidly extending necrotic ulceration of the scrotum. A few days previously, inflammatory chemosis of the right eye had suddenly developed. Under systemic corticosteroids (1.5 mg/kg/day), the ophthalmic symptoms rapidly regressed, but the patient died of digestive tract haemorrhage. The third case was that of a 36-year old woman with urticaria associated with arthralgias and diffuse myalgia.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1983

[Proposed treatment of the Urrets-Zavalia syndrome. A propos of one reversible case].

Regression of Urrets-Zavalia's syndrome was obtained in one case after treatment administered according to a strict sequence following keratoplasty for keratoconus: sympatholytic drops (guanethidine 5%-Ismelin) every 4 hours for 24 hours, followed the next day, when mydriasis had been slightly reduced, by parasympathomimetic drops (pilocarpine 2%). Marked myosis was observed and treatment discontinued. This resulted in recurrence of the mydriasis, but this was successfully treated by repeating therapy. Pilocarpine drops were progressively diminished, followed by a slow reduction of guanethidine drops over 8 weeks, resulting in only slight residual anisocoria. This treatment is based on the physiopathological concept of sympathetic spasm with parasympathetic inhibition, and it is suggested that reduction of spasm should be obtained before administration of therapy to stimulate the sphincter. Pharmacological data on the compounds employed are discussed.

Adult↗
PubMed1981

[Cornea and neovascularisation: a physiopathological study (author's transl)].

Analysis of clinical data and reports in the published literature are employed to develop a physiopathological explanation for corneal neovascularisation, based on a chain reaction in which inflammation and hypoxia play essential roles. The possible advantages and disadvantages that result from this neovascularisation are analysed. There is no fundamental reason for the administration of antivascular therapy alone, and treatment should be directed towards the inflammatory process, which is the cause of the neovascularisation and the opacities. By reducing or suppressing the inflammatory chain reaction it is then possible to break the vicious circle of a possible self-supporting affection.

Adrenal Cortex Hormones↗